{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"Life Science Solutions","title":"Particles in Biologics: Advanced Analytics and Tech Transfer","html":"<iframe width=\"100%\" height=\"180\" frameborder=\"no\" scrolling=\"no\" seamless src=\"https://share.transistor.fm/e/bf9407f3\"></iframe>","width":"100%","height":180,"duration":1488,"description":"For many teams, particles and aggregates are treated as a late-stage compliance headache or a sudden fire drill during manufacturing. But what if we looked closer? Particle populations can actually reveal deep insights about your formulation stability, process robustness, and potential technology transfer risks long before you reach commercial scale.\nIn this episode of Life Science Solutions, host Chris Adkins sits down with Dr. Tim Menzen, Chief Technology Officer at Coriolis Pharma, a science-driven CRO specializing in formulation development and advanced analytics for biopharmaceuticals. With a PhD focused on the thermal unfolding and aggregation of monoclonal antibodies, Tim brings a wealth of expertise to the evolving landscape of biologic particles.\nIf your organization is looking to modernize how it approaches formulation and process development, this conversation is packed with cutting-edge insights.\nTopics Include:\nThe Evolution of Antibodies: How improved molecular engineering has shifted the industry away from from-scratch formulation and toward streamlined \"formulability assessments\".\nTech Transfer Risks: Why pumps are famously considered \"particle generating machines,\" and why true like-for-like process transfers rarely exist.Subvisible vs. Visible: Why waiting for visual particles is like ignoring a flashing red light, and how characterizing submicron particles early helps identify root causes.\nOrthogonal Analytics: Moving beyond traditional pharmacopeia methods (like sizing and counting) to determine exact particle morphology, such as distinguishing a silicone oil droplet from a fluffy protein aggregate.\nParticle Fingerprinting: How flow imaging microscopy and AI are being used to create two-dimensional \"fingerprints\" to compare the morphological density of particles across different processes.\nThe Future of Formulation: What’s next on the horizon, including in silico computer simulations, multi-dimensional data instruments, and assay...","thumbnail_url":"https://img.transistorcdn.com/NJUQJpllzMReojwXSp4vxSqDlm-PIulGozVxmRVQnJE/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS8yOGM2/NjIwZTU1YjljMDM5/ZGRhMWZhODQ2OTAx/NjliZS5wbmc.webp","thumbnail_width":300,"thumbnail_height":300}