{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"Works in Progress Podcast","title":"The first cancer vaccine","html":"<iframe width=\"100%\" height=\"180\" frameborder=\"no\" scrolling=\"no\" seamless src=\"https://share.transistor.fm/e/c3fe70dd\"></iframe>","width":"100%","height":180,"duration":10727,"description":"Hepatitis B is a tiny virus that causes hundreds of thousands of deaths from liver disease and cancer each year. The vaccine against it became the first of many milestones: it was the first viral protein subunit vaccine, the first recombinant vaccine, and the first vaccine to prevent a type of cancer. \nIn this episode, Jacob and Saloni follow the trail of strange jaundice outbreaks that scientists traced to a stealthy liver virus, how scientists turned one viral surface protein into a lifesaving shot for newborns, and how it was all built upon breakthroughs in immunology.\nHard Drugs is a new podcast from Works in Progress and Coefficient Giving about medical innovation presented by Saloni Dattani and Jacob Trefethen.\n\nYou can watch or listen on YouTube, Spotify, or Apple Podcasts.\nSaloni’s substack newsletter: https://www.scientificdiscovery.dev/\n\nJacob’s blog: https://blog.jacobtrefethen.com/ \nBooks:\nPaul Offit (2007) Vaccinated: One Man's Quest to Defeat the World's Deadliest Diseases\nArthur M Silverstein (2009) A history of immunology\nRonald W Ellis (1993) Hepatitis B Vaccines in Clinical Practice\nSally Smith Hughes (2011) Genentech: The beginnings of biotech\nArticles:\nTimothy M. Block et al. (2016) A historical perspective on the discovery and elucidation of the hepatitis B virus https://doi.org/10.1016/j.antiviral.2016.04.012 \nNaijuan Yao et al. (2022) Incidence of mother-to-child transmission of hepatitis B in relation to maternal peripartum antiviral prophylaxis: A systematic review and meta-analysis https://doi.org/10.1111/aogs.14448\nJill Koshiol et al. (2019) Beasley’s 1981 paper: The power of a well-designed cohort study to drive liver cancer research and prevention https://pmc.ncbi.nlm.nih.gov/articles/PMC5866222/ \nWilliam J. McAleer et al. (1984) Human hepatitis B vaccine from recombinant yeast https://doi.org/10.1038/307178a0 \nChunfeng Qu et al. (2014) Efficacy of Neonatal HBV Vaccination on Liver Cancer and Other Liver Diseases over 30-Year...","thumbnail_url":"https://img.transistorcdn.com/6LM5UVWr309T-olggTJ9aOP2eEvMfZ2AVhMyFCHS3hY/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS8zNWU2/YzBmZDQ1MDY1YTQx/YTM0ZTVmZDk1ZjEz/NjFmYi5wbmc.webp","thumbnail_width":300,"thumbnail_height":300}