{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"萌喵读文献-生物信息学","title":"今日生物信息学最高分文献 - 2024-11-26","html":"<iframe width=\"100%\" height=\"180\" frameborder=\"no\" scrolling=\"no\" seamless src=\"https://share.transistor.fm/e/c49237b4\"></iframe>","width":"100%","height":180,"duration":4,"description":"欢迎收听今日医学播客！最新研究发现，PIEZO1蛋白通过抑制TGF-β信号通路，有望成为治疗马凡综合征的新靶点。马凡综合征是一种遗传性疾病，常导致主动脉瘤等严重心血管问题。研究显示，PIEZO1在患者体内的表达降低，而敲除PIEZO1会加剧主动脉瘤的发展。通过激活PIEZO1，可以有效抑制TGF-β信号通路的激活，减缓主动脉瘤形成。这一发现为开发治疗马凡综合征的新药提供了重要线索。敬请关注更多医学资讯，我们下期再见！","thumbnail_url":"https://img.transistorcdn.com/38WU46uKrju37cyiLrKcVSktFL4vxBb_oTgbpM_2CRw/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS8zOGU2/ZmEyYWE0MDZkNGFj/NWMzNGY5ZmU4YTk0/ZTBlNS5qcGc.webp","thumbnail_width":300,"thumbnail_height":300}