{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"萌喵读文献-生物信息学","title":"今日生物信息学最高分文献 - 2025-10-24","html":"<iframe width=\"100%\" height=\"180\" frameborder=\"no\" scrolling=\"no\" seamless src=\"https://share.transistor.fm/e/c7540552\"></iframe>","width":"100%","height":180,"duration":200,"description":"科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注发表在影响因子12.5的《Cancer research》上的重要研究：\"RORγ Hijacks HIF-1α to Promote Peritoneal Metastasis of Gastric Cancer\"。该研究由中山大学和电子科技大学的团队合作完成，揭示了RORγ是胃癌腹膜转移的关键驱动因子。研究发现，胃癌缺氧微环境刺激RORγ表达，进而增强HIF-1α稳定性，形成正反馈回路。这一相互作用促进肿瘤细胞适应缺氧环境并加速腹膜转移。更令人振奋的是，使用RORγ拮抗剂可有效阻断肿瘤生长和转移，同时增强化疗敏感性。这一发现为晚期胃癌腹膜转移提供了潜在的治疗新靶点，具有重要的临床转化价值。","thumbnail_url":"https://img.transistorcdn.com/38WU46uKrju37cyiLrKcVSktFL4vxBb_oTgbpM_2CRw/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS8zOGU2/ZmEyYWE0MDZkNGFj/NWMzNGY5ZmU4YTk0/ZTBlNS5qcGc.webp","thumbnail_width":300,"thumbnail_height":300}