{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"萌喵读文献-生物信息学","title":"今日生物信息学最高分文献 - 2025-12-20","html":"<iframe width=\"100%\" height=\"180\" frameborder=\"no\" scrolling=\"no\" seamless src=\"https://share.transistor.fm/e/c9c574fe\"></iframe>","width":"100%","height":180,"duration":215,"description":"科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。今天我们关注发表在《Journal of nanobiotechnology》(IF: 10.6)上的重要研究：\"Porphyromonas gingivalis extracellular vesicles promotes tumor metastasis in esophageal squamous cell carcinoma by inducing PRKACB/JNK/NFATC2 axis\"。这项来自武汉大学人民医院的研究发现，常见口腔细菌牙龈卟啉单胞菌的细胞外囊泡能通过激活PRKACB/JNK/NFATC2信号轴，显著促进食管鳞癌的转移。研究团队在临床样本和实验模型中均证实，这种细菌的存在与患者不良预后、肿瘤分期和淋巴结转移密切相关。这一发现不仅揭示了口腔微生物与食管癌转移的新机制，也为开发针对口腔菌群干预的癌症治疗策略提供了重要科学依据。","thumbnail_url":"https://img.transistorcdn.com/38WU46uKrju37cyiLrKcVSktFL4vxBb_oTgbpM_2CRw/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS8zOGU2/ZmEyYWE0MDZkNGFj/NWMzNGY5ZmU4YTk0/ZTBlNS5qcGc.webp","thumbnail_width":300,"thumbnail_height":300}