{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"Board Pearls","title":"Chapter 14, Ep 1 of 3: UC Complete","html":"","width":"100%","height":180,"duration":1086,"description":"Episode one of three on inflammatory bowel disease, covering ulcerative colitis from classification through full medical management. Walks the UC-versus-Crohn distinction, the Mayo score driving severity-tiered therapy, the acute severe UC inpatient script with its day-three salvage rule, mesalamine for mild-to-moderate disease, and mechanism-based positioning of biologics and small molecules. Board-focused framework for choosing therapy by matching drug mechanism to patient phenotype.\n \nTopics covered\n\nUC vs Crohn distinction\nMontreal extent classification\nMayo score and severity\nAcute severe UC management\nMesalamine formulations and delivery\nBiologics and small molecules\nJAK and S1P modulators\nMechanism-to-patient drug selection\n \n \nKey decisions\n\nSmoking is protective in UC but harmful in Crohn's; a quiescent UC patient who quits can flare within months.\nDay three is the salvage trigger in acute severe UC: Oxford rule is more than eight stools daily, or three to eight stools with CRP above forty-five.\nSalvage is a single shot: no response to infliximab or cyclosporine within five to seven days means colectomy, not sequential salvage.\nAntimotility agents are contraindicated in acute severe UC because they precipitate toxic megacolon; anticoagulate despite rectal bleeding.\nCombined oral plus topical mesalamine beats either alone for distal and left-sided disease; oral induction dose is 4.8 g/day.\nSulfasalazine wins in the UC patient with peripheral inflammatory arthritis; give mandatory folic acid, and mesalamine paradoxical worsening means stop the drug.\n \n \nThis is an AI-generated podcast, and some pronunciations may be imperfect. Thank you for your understanding, and we hope you enjoyed this content.\n \n \nStudy the full chapter on Board Pearls, with practice questions, tables and primary-guideline references: Inflammatory Bowel Disease\nRead this episode: boardpearls.com/gi/episodes/ibd-ep1\nQuestions or feedback: hello@boardpearls.com.","thumbnail_url":"https://img.transistorcdn.com/-FuAdDBcPDLhEoUmroZKtOBRvuBn_FHPpYlh41hOnU4/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS9iNzlh/ZTU4Y2MzNWExMjQ5/MjA5OWMwMmI3ZTk5/NGFiZS5wbmc.webp","thumbnail_width":300,"thumbnail_height":300}