{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"Vector Signals","title":"Novel Quinolones Counteract Insecticide Resistance in Malaria Vectors (May 2025)","html":"<iframe width=\"100%\" height=\"180\" frameborder=\"no\" scrolling=\"no\" seamless src=\"https://share.transistor.fm/e/d46c4502\"></iframe>","width":"100%","height":180,"duration":1499,"description":"BRIEFING DOCUMENT: Novel Approach to Malaria Control Targeting Mosquito-Stage Plasmodium Parasites\nDate: Received - 29 March 2025 | Accepted - 17 April 2025 | Published - 21 May 2025\nSource: Excerpts from \"In vivo screen of Plasmodium targets for mosquito-based malaria control\" by Probst et al. (Published online xx xx xxxx, Nature) https://doi.org/10.1038/s41586-025-09039-2\nSubject: Development and testing of novel antiparasitic compounds for incorporation into mosquito bed nets to combat insecticide resistance and reduce malaria transmission.\nSummary:\nThis research presents a promising new strategy for malaria control by targeting the Plasmodium falciparum parasite directly within its mosquito vector (Anopheles species). Recognizing the growing challenge of insecticide resistance in mosquitoes, the study explores the potential of incorporating antiparasitic compounds into long-lasting insecticide-treated nets (LLINs). The authors performed an in vivo screen of 81 compounds, identifying 22 active against mosquito-stage parasites. Notably, endochin-like quinolones (ELQs) targeting the parasite's cytochrome bc1 complex (CytB) showed high potency and were further optimized through medicinal chemistry. Two lead ELQ compounds, ELQ-453 and ELQ-613, demonstrated potent, long-lasting activity when incorporated into bed net-like materials, including in insecticide-resistant mosquitoes. The study also highlights the potential of a dual-target strategy using a combination of Qo-site and Qi-site ELQ inhibitors to reduce the risk of resistance, as CytB mutants show impaired development in mosquitoes. This approach offers a complementary tool to existing malaria control strategies, particularly in areas with high insecticide resistance.\nKey Themes and Important Ideas/Facts:\nMalaria Burden and the Challenge of Insecticide Resistance:\nMalaria deaths have stalled in recent years, with an estimated 263 million cases and 597,000 deaths in 2023.\nVector control, particularly LLINs,...","thumbnail_url":"https://img.transistorcdn.com/qJYlR2Phxe3IMx6KHnsmKp1D71DIqj8LuYMSrDKo9Jc/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS82MDgx/MDIyNmJkNWU5YmIz/NzJhZDVmZjYyOGZi/NTgxMi53ZWJw.webp","thumbnail_width":300,"thumbnail_height":300}