{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"Blood Cancer Talks","title":"Episode 38. GVHD Prophylaxis in Allo-Transplant with Dr. Shernan Holtan","html":"<iframe width=\"100%\" height=\"180\" frameborder=\"no\" scrolling=\"no\" seamless src=\"https://share.transistor.fm/e/e03bf9fd\"></iframe>","width":"100%","height":180,"duration":3130,"description":"In this episode, we talk about GVHD prophylaxis, including recent data on post-transplant cyclophosphamide and abatacept with Dr. Shernan Holtan from the University of Minnesota. \nHere are the key trials we discussed:\n1. BMT CTN 1203 trial: Three prophylaxis regimens (tacrolimus, mycophenolate mofetil, and cyclophosphamide; tacrolimus, methotrexate, and bortezomib; or tacrolimus, methotrexate, and maraviroc) versus tacrolimus and methotrexate for prevention of GVHD in allogeneic transplantation.\n \nhttps://pubmed.ncbi.nlm.nih.gov/30824040/\n \n2. BMT CTN 1703 study: Post-Transplantation Cyclophosphamide-Based GVHD prophylaxis \n \nhttps://pubmed.ncbi.nlm.nih.gov/37342922/\n \n3. Patient-Reported Outcomes of BMT CTN 1703\n \nhttps://ash.confex.com/ash/2023/webprogram/Paper187859.html\n \n4. Phase II Study of Myeloablative 7-8/8-Matched Allotransplantation with Post-Transplantation Cyclophosphamide, Tacrolimus, and Mycophenolate Mofetil\n \nhttps://pubmed.ncbi.nlm.nih.gov/37311510/\n \n5. BMT CTN 1301 trial: Randomized Phase III BMT CTN Trial of Calcineurin Inhibitor-Free Chronic Graft-Versus-Host Disease Interventions in Myeloablative Hematopoietic Cell Transplantation for Hematologic Malignancies\n \nhttps://pubmed.ncbi.nlm.nih.gov/34855460/\n \n6. Phase II Trial of Costimulation Blockade With Abatacept for Prevention of Acute GVHD (ABA2)\n \nhttps://pubmed.ncbi.nlm.nih.gov/33449816/\n \n7. Aurora Kinase a Inhibition for Gvhd and Relapse Prevention after Allogeneic HCT: Phase I Trial in Combination with Ptcy/Sirolimus\n \nhttps://ash.confex.com/ash/2023/webprogram/Paper181292.html","thumbnail_url":"https://img.transistorcdn.com/sqlYzk0Oxhchi1Lmft_9Md8dG97D7hyy2rwRG7COuc0/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS9zaG93/LzMyMDc4LzE2NTcz/MTQxMDUtYXJ0d29y/ay5qcGc.webp","thumbnail_width":300,"thumbnail_height":300}