{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"Proteomics in Proximity","title":"Mechanism of Action of an SGLT2 Inhibitor","html":"<iframe width=\"100%\" height=\"180\" frameborder=\"no\" scrolling=\"no\" seamless src=\"https://share.transistor.fm/e/e5566ff8\"></iframe>","width":"100%","height":180,"duration":1591,"description":"Highlighted publication: Zannad F, Ferreira JP, Butler J, Filippatos G, Januzzi JL, Sumin M, Zwick M, Saadati M, Pocock SJ, Sattar N, Anker SD, Packer M. Effect of empagliflozin on circulating proteomics in heart failure: mechanistic insights into the EMPEROR programme. Eur Heart J. (2022) 43(48):4991-5002. doi:10.1093/eurheartj/ehac495. PMID: 36017745; PMCID: PMC9769969.\nReview paper of research by Voltar Longo and David Sinclair on longevity and aging, mentioning sirtuins and mTOR. Longo VD, Antebi A, Bartke A, Barzilai N, Brown-Borg HM, Caruso C, Curiel TJ, de Cabo R, Franceschi C, Gems D, Ingram DK, Johnson TE, Kennedy BK, Kenyon C, Klein S, Kopchick JJ, Lepperdinger G, Madeo F, Mirisola MG, Mitchell JR, Passarino G, Rudolph KL, Sedivy JM, Shadel GS, Sinclair DA, Spindler SR, Suh Y, Vijg J, Vinciguerra M, Fontana L. Interventions to Slow Aging in Humans: Are We Ready? Aging Cell. 2015 Aug;14(4):497-510. doi: 10.1111/acel.12338. Epub 2015 Apr 22. PMID: 25902704; PMCID: PMC4531065.\nGeneral information about Empaglifozin (Jardiance) on Wikipedia is here. \nIn case you were wondering, Proteomics in Proximity refers to the principle underlying Olink Proteomics assay technology called the Proximity Extension Assay (PEA), and more information about the assay and how it works can be found here.\n\nWould you like to subscribe to the podcast on your favorite player or app? You can do so here: \nApple Podcasts: https://apple.co/3T0YbSm\nSpotify Podcasts: https://open.spotify.com/show/2sZ2wxOqI4b4vSngkajLs8?si=d957d55c8db046f7 Google Podcasts: https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy50cmFuc2lzdG9yLmZtL3Byb3Rlb21pY3MtaW4tcHJveGltaXR5\nAmazon Music: https://music.amazon.com/podcasts/d97ace94-f02b-4b37-9532-799548ef2840\nPodcast Addict: https://podcastaddict.com/podcast/4098296\nDeezer: https://www.deezer.com/show/5178787\nPlayer FM: https://player.fm/series/series-3396598","thumbnail_url":"https://img.transistorcdn.com/ykdESoQYqhzogcyTRtlZ-HocZhd_d0QETSq8cMzg1DE/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS9zaG93/LzM0MDk0LzE2NjMx/OTI3MzUtYXJ0d29y/ay5qcGc.webp","thumbnail_width":300,"thumbnail_height":300}