{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"萌喵读文献-生物信息学","title":"今日生物信息学最高分文献 - 2026-02-11","html":"<iframe width=\"100%\" height=\"180\" frameborder=\"no\" scrolling=\"no\" seamless src=\"https://share.transistor.fm/e/e8ba3f2b\"></iframe>","width":"100%","height":180,"duration":184,"description":"科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。今天为大家介绍发表在《Circulation research》(影响因子16.5)上的重要研究\"Cardiac Macrophages and Fibroblasts Modulate Atrial Fibrillation Maintenance\"。这项突破性研究发现心房颤动的持续与特定区域中的细胞表型变化密切相关。研究团队在猪模型和人类患者中确认，驱动心房颤动的区域富含PTX3-成纤维细胞和具有特殊基因表达的心脏驻留巨噬细胞。最令人振奋的是，针对这些驱动区域进行精准消融，在猪模型中可成功终止心房颤动，在人类患者中实现了90%的两年无颤动率。这一发现为心房颤动的精准治疗提供了全新靶点，有望改变临床实践。","thumbnail_url":"https://img.transistorcdn.com/38WU46uKrju37cyiLrKcVSktFL4vxBb_oTgbpM_2CRw/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS8zOGU2/ZmEyYWE0MDZkNGFj/NWMzNGY5ZmU4YTk0/ZTBlNS5qcGc.webp","thumbnail_width":300,"thumbnail_height":300}