{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"萌喵读文献-生物信息学","title":"今日生物信息学最高分文献 - 2026-01-16","html":"<iframe width=\"100%\" height=\"180\" frameborder=\"no\" scrolling=\"no\" seamless src=\"https://share.transistor.fm/e/eae2d5f5\"></iframe>","width":"100%","height":180,"duration":208,"description":"科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注发表在Nature Methods（影响因子36.1）上的重要论文\"Integration of imaging-based and sequencing-based spatial omics mapping on the same tissue section via DBiTplus\"。这项研究介绍了DBiTplus技术革命性地实现了在同一组织切片上进行空间转录组学和多重蛋白成像的整合分析。这一突破性技术能够在保持组织结构完整性的同时，提供单细胞分辨率的细胞类型分析和转录组水平的生物通路探索。研究团队在多种临床样本中验证了该技术，包括冷冻小鼠胚胎和人淋巴瘤组织，成功揭示了淋巴瘤发生和进展的关键机制。DBiTplus为构建空间分辨的单细胞图谱和以细胞为单位探索生物学机制提供了统一工作流程，将极大地推动精准医学和癌症研究的发展。","thumbnail_url":"https://img.transistorcdn.com/38WU46uKrju37cyiLrKcVSktFL4vxBb_oTgbpM_2CRw/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS8zOGU2/ZmEyYWE0MDZkNGFj/NWMzNGY5ZmU4YTk0/ZTBlNS5qcGc.webp","thumbnail_width":300,"thumbnail_height":300}