{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"Blood Cancer Talks","title":"Episode 15. Management of Newly Diagnosed DLBCL (Including Bonus ASH22 Updates)","html":"<iframe width=\"100%\" height=\"180\" frameborder=\"no\" scrolling=\"no\" seamless src=\"https://share.transistor.fm/e/ec6657e5\"></iframe>","width":"100%","height":180,"duration":3224,"description":"In this episode, we discuss the management of newly diagnosed DLBCL with Dr. Pallawi Torka. We also have a few bonus ASH22 updates on DLBCL. Links to articles and abstracts discussed in the episode are as follows: \n1. A comprehensive review article on DLBCL:\nhttps://pubmed.ncbi.nlm.nih.gov/33657296/\n \n2. RCT testing CHOP vs Three Intensive Regimens in DLBCL:\nhttps://www.nejm.org/doi/full/10.1056/nejm199304083281404 \n \n3. RCT testing R-CHOP vs CHOP in DLBCL in older adults:\nhttps://www.nejm.org/doi/full/10.1056/nejmoa011795 \n \n4. RCT testing R-CHOP vs CHOP in young (MINT):\nhttps://pubmed.ncbi.nlm.nih.gov/21940214/ \n \n5. PHOENIX trial: R-CHOP +/- Ibrutinib:\nhttps://pubmed.ncbi.nlm.nih.gov/30901302/\n \n6. R-CHOP +/- Lenalidomide (ECOG-ACRIN E1412):\nhttps://pubmed.ncbi.nlm.nih.gov/33555941/ \n \n7. R-CHOP vs Pola-R-CHP (POLARIX Trial):\nhttps://www.nejm.org/doi/full/10.1056/NEJMoa2115304\n \n8. Comparison of 3 IPI scores in DLBCL:\nhttps://ashpublications.org/blood/article/135/23/2041/452696\n \n9. RCT testing R-CHOP vs Dose-Adjusted R-EPOCH (CALGB 50303):\nhttps://ascopubs.org/doi/full/10.1200/JCO.18.01994\n \n10. Timing of CNS Prophylaxis in DLBCL:\nhttps://pubmed.ncbi.nlm.nih.gov/34995350/\n \n11. RCT testing R-CHOP vs R-CHOP + Bortezomib (REMoDL-B):\nhttps://pubmed.ncbi.nlm.nih.gov/30948276/\n \n12. Interim PET in DLBCL? \nhttps://ashpublications.org/bloodadvances/article/5/9/2375/475850\n \n13. RCTs in Limited Stage DLBCL:\n \nCHOP x 8 vs CHOP x 3 + XRT (S8736):\nhttps://ascopubs.org/doi/10.1200/JCO.2015.65.4582\n \nCHOP x 4 + Rituximab x 6 vs R-CHOP x 6 (FLYER):\nhttps://pubmed.ncbi.nlm.nih.gov/31868632/\n \nPET-adapted therapy with R-CHOP (S1001):\nhttps://pubmed.ncbi.nlm.nih.gov/32658627/\n \n14.   ASH 2022 updates:\nREMoDL-B update: https://ashpublications.org/blood/article/140/Supplement%201/1770/493225\n \nGlofitamab update: https://ashpublications.org/blood/article/140/Supplement%201/1062/491024\n \nEpcoritamab update: https://ashpublications.org/blood/article/140/Supplement%201/9443/488543","thumbnail_url":"https://img.transistorcdn.com/sqlYzk0Oxhchi1Lmft_9Md8dG97D7hyy2rwRG7COuc0/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS9zaG93/LzMyMDc4LzE2NTcz/MTQxMDUtYXJ0d29y/ay5qcGc.webp","thumbnail_width":300,"thumbnail_height":300}