{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"萌喵读文献-肿瘤学","title":"今日肿瘤学最高分文献 - 2025-09-14","html":"<iframe width=\"100%\" height=\"180\" frameborder=\"no\" scrolling=\"no\" seamless src=\"https://share.transistor.fm/e/ec86984d\"></iframe>","width":"100%","height":180,"duration":196,"description":"科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注发表在《Trends in pharmacological sciences》(IF: 13.9)上的综述《The B7-H3 (CD276) pathway: emerging biology and clinical therapeutics》。这项研究揭示了B7-H3作为免疫检查点配体和肿瘤相关抗原的多重功能，不仅参与二聚化、糖基化和细胞代谢调控，还发现其作为肥胖调节剂的新作用。临床试验证明，针对B7-H3的抗体药物偶联物和CAR免疫细胞在不同癌症中安全有效。研究还介绍了多种新型靶向疗法，包括TOP CAR细胞、双特异性ADCs和CAR-NK细胞，为癌症免疫治疗开辟了新途径。","thumbnail_url":"https://img.transistorcdn.com/3WX36CzvFOrNjlF7WfWjzS4HdcMIMmzMs2bmPS-ejLU/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS83NDNm/MjQ1N2E5NjhjMzVj/NjM0ZTA3YzY2NDE2/ZmIyMi5qcGc.webp","thumbnail_width":300,"thumbnail_height":300}