{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"PancChat Podcast with Alisyn Camerota","title":"The KRAS Mutation","html":"<iframe width=\"100%\" height=\"180\" frameborder=\"no\" scrolling=\"no\" seamless src=\"https://share.transistor.fm/e/fad4e3ba\"></iframe>","width":"100%","height":180,"duration":1580,"description":"Up to 95% of pancreatic cancer patients have a KRAS mutation in their tumor. For decades, it was considered impossible to target with a drug. What changed?\nTo get the latest information, host Alisyn Camerota is joined by Dr. Eileen O'Reilly, medical oncologist and Winthrop Rockefeller Endowed Chair in Medical Oncology at Memorial Sloan Kettering Cancer Center, to unpack what RAS and KRAS actually are, why this gene resisted treatment for so long, and what the recent approval of Rasonque™ (daraxonrasib) means for patients with metastatic pancreatic cancer.\nDr. O'Reilly explains the biology behind RAS signaling, the different mutation types found in pancreatic cancer (including G12D, G12V, and G12R), how the new class of RAS-targeting drugs works, what testing for a RAS mutation involves, and what \"RAS wild type\" means for the small subset of patients without a detectable mutation. She also shares her perspective on what this breakthrough means for the field after years of limited progress, and where research is headed next.\nPancChat is produced in collaboration with Let's Win Pancreatic Cancer and PanCAN.\nPancChat is sponsored by Revolution Medicines.\nResources:\nFDA Approves RASONQUE™ (daraxonrasib) - PanCAN\nThe FDA Approves Rasonque™ (Daraxonrasib) - Let's Win\nDaraxonrasib: What To Know About Common Side Effects\nLet's Win Pancreatic Cancer\nPancreatic Cancer Action Network (PanCAN)\nLet's Win Clinical Trial Finder\nPanCAN Clinical Trial Finder\nLet's Win Doctor Finder\nPanCAN Patient Services","thumbnail_url":"https://img.transistorcdn.com/cAJEAPlDE1maKBGcgHeLPBFdNegZ6bz0Ol0rS-Dsvj0/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS9mZThh/MzliZmRmOThiY2U5/ZGNlNWI0MGE2Mjdj/NDkzMy5wbmc.webp","thumbnail_width":300,"thumbnail_height":300}