{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"萌喵读文献-生物信息学","title":"今日生物信息学最高分文献 - 2026-01-18","html":"<iframe width=\"100%\" height=\"180\" frameborder=\"no\" scrolling=\"no\" seamless src=\"https://share.transistor.fm/e/fb2cefb3\"></iframe>","width":"100%","height":180,"duration":206,"description":"科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注发表在《Cell》(影响因子45.5)上的重要研究\"Continuum architecture dynamics of vesicle tethering in exocytosis\"。这项突破性研究揭示了胞吐作用中囊泡固定的分子机制，发现7个外排体形成环状高阶结构，通过三个亚稳态(27、18和5纳米)的分步机制将囊泡拉向质膜。研究还证实Sec18介导的结构解体控制胞吐速率，为理解细胞分泌过程提供了全新视角。这一发现不仅深化了对细胞生物学基本过程的认识，还可能为开发靶向分泌相关疾病的新疗法奠定基础。","thumbnail_url":"https://img.transistorcdn.com/38WU46uKrju37cyiLrKcVSktFL4vxBb_oTgbpM_2CRw/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS8zOGU2/ZmEyYWE0MDZkNGFj/NWMzNGY5ZmU4YTk0/ZTBlNS5qcGc.webp","thumbnail_width":300,"thumbnail_height":300}