{"type":"rich","version":"1.0","provider_name":"Transistor","provider_url":"https://transistor.fm","author_name":"萌喵读文献-肿瘤学","title":"今日肿瘤学最高分文献 - 2025-09-14","html":"<iframe width=\"100%\" height=\"180\" frameborder=\"no\" scrolling=\"no\" seamless src=\"https://share.transistor.fm/e/fd2a8fc0\"></iframe>","width":"100%","height":180,"duration":127,"description":"科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。今天我们要介绍一篇发表在《Trends in pharmacological sciences》(影响因子13.9)上的重要综述——《The B7-H3 (CD276) pathway: emerging biology and clinical therapeutics》。这项研究揭示了B7-H3这一免疫检查点配体在癌症和肥胖中的双重作用，不仅是一种肿瘤相关抗原，还新发现它能调节肥胖。更令人兴奋的是，靶向B7-H3的抗体药物偶联物和CAR细胞疗法已在临床试验中展现出良好的安全性和有效性。这些突破性发现为癌症免疫治疗开辟了新途径，可能改变未来多种癌症的治疗格局。","thumbnail_url":"https://img.transistorcdn.com/3WX36CzvFOrNjlF7WfWjzS4HdcMIMmzMs2bmPS-ejLU/rs:fill:0:0:1/w:400/h:400/q:60/mb:500000/aHR0cHM6Ly9pbWct/dXBsb2FkLXByb2R1/Y3Rpb24udHJhbnNp/c3Rvci5mbS83NDNm/MjQ1N2E5NjhjMzVj/NjM0ZTA3YzY2NDE2/ZmIyMi5qcGc.webp","thumbnail_width":300,"thumbnail_height":300}