016 Training Splits - Why upper/lower, torso/limbs, push/pull, and other split routines face the same problem

In this episode of Hypertrophy: Past and Present, Jake and Chris revisit Joe Weider’s early 1940 full-body program before breaking down the central problem that all split routines face: supraspinal CNS fatigue.

Key topics include:

• How calcium-ion–related fatigue and inflammation create global CNS fatigue
• Why back-to-back training days reduce recruitment, even for unrelated muscles
• Why full-body AAA and AB formats avoid these issues

What is Hypertrophy Past and Present?

A deep dive into the science of muscle growth. Hosted by Chris Beardsley and Jake Doleschal, this podcast explores hypertrophy training through the lens of pre-steroid era bodybuilding and modern muscle physiology.