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Welcome to Oxford+, the podcast series
that takes you deep into the myths and

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truths of the Oxford investing landscape.

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I'm your host, Susannah de
Jager and I've spent over 15

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years in UK asset management.

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My guest today is Ed Bussey.

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Ed studied natural sciences at
Cambridge University before starting

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his career serving in counter terrorism
operations with the UK military

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and national security agencies.

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Ed recently took on the role as CEO of
OSE, Oxford Science Enterprises, which

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was originally Oxford Science Innovation.

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As mentioned in my last interview with
the OSI founder Dave Norwood, OSE is

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the largest university venture fund
globally and has brought in over 1.

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5 billion of capital to Oxford
since its inception in 2015.

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Ed is a serial entrepreneur and
leading UK technology expert having

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launched, scaled and successfully
exited three venture-backed

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disruptive technology businesses.

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I'm really pleased to have Ed here
today, as one of the main messages

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of Oxford+ is to dispel myths
and expose truths around Oxford.

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OSE is a huge part of the ecosystem and
is often the subject of many of these.

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Ed's views and plans on how to
disprove, overcome or dispel some

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of these will be exceptionally
informative for anyone who has or

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thinks they should invest into Oxford.

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So, Ed, thank you so
much for joining today.

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My pleasure, it's great to be here.

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Wonderful.

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So, how is it going?

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Five months in.

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It's the best job in the
world, honestly, really.

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It's almost as if I had to design the
ideal role for me, it's the culmination

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of everything I've done along my journey.

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I studied science, dare I say, at
Cambridge rather than Oxford, but that

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gives me a, but yeah, but that does
mean when I say Oxford is the number

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one research university in the world,
I'm saying that very objectively based

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off the fact that that's the case.

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The period I spent in government
is also proving to be very relevant

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and the last two decades, I've
spent building disruptive technology

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companies from the ground up through
to exit and fundamentally what OSE is

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doing, beyond investing, is building
sort of world changing businesses.

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So to bring this all together in a
leadership role is just perfect for me.

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I'm not pretending it's without its
challenges, but I actually think this

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job is a real privilege, if I look at
what we're doing and with the sorts

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of companies and the sort of impact
that they're going to have and are

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having, is quite humbling actually.

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I'm very pleased to hear
that, that's wonderful.

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I've heard it said that in the UK there's
a sort of criticism of venture capital,

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of which this is a particular kind of
venture building out of universities,

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that it's often intermediated by
financiers and accountants and

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that's a kind of complaint about the
fact that it's not entrepreneurs.

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So you obviously do have, as
you just referenced, a very

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entrepreneurial background.

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How do you think that's different in the
way that you're approaching the new role?

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Yeah, so I'm lucky that on the
same time I joined, I was joined

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by Jack Edmondson who's come in as
our Chief Investment Officer and

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two parts really to the answer.

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One is, how do I see things differently?

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I guess first off, I am a founder.

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I've been through that journey and I
know how painful it is, I've run out

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of money, I have had very difficult
conversations with my investors, I have

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slept in the office, I have had sleepless
nights, had to sacrifice all that goes

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with building a business, whether that's
with family and friends and so on.

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So I come at this with a very natural
empathy for what the founders of our

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businesses are going through and I think
that's a really healthy perspective

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to have, because whether we agree with
everything that our founders say, I know

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that at the end of the day, these are the
people that need the most support and help

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and so that for me is front and center.

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So I'm really enjoying going out and
getting time with the portfolio companies,

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the founders, and so on, we're doing
site visits, Jack and I, you know, we'll

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be, we'll work our way through the whole
portfolio, we're about 40 percent through

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the core portfolio already, so I think
that perspective is a really helpful one.

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You're like a peer, aren't you really?

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Yeah, I can speak to them as a peer.

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I can really relate to the decisions
around, you know, the hard decisions

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and tradeoffs you're making maybe on a
funding round and you take money from

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this investor or that investor and the
things to watch out for the challenge in

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the UK, the pressure to sell early, and
you know, I've been there and I know the

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conversations that I'd like to have had
with my investors, but frankly never did.

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So I can then start to maybe be a
more helpful, empathetic sounding

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board from the investor side.

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So I think that's important.

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The second part of the answer is with
Jack, as I say, joining alongside me as

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CIO and OSE having split the role into
two parts, frankly I am not clear how

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it could have been done properly as a
merged role historically, because they're

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two completely different skill sets.

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So my role as CEO at OSE is to design
a strategy and execute that strategy

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with a focus on how do we do that?

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How do we build and scale
the organization efficiently?

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And what I've done all the way through
my journey is work through in different

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sectors, how do you efficiently scale
organizations and deliver results?

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And Jack's focus alongside me is on making
very high quality investment decisions

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and running a very robust investment
process, but that is a skill set that,

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you know, he has clear expertise and
experience of, I have received that

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money, but my focus is on how do we
organise OSE efficiently to scale?

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Because I want to really challenge
all of our stakeholders, our

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investors, our team to be much more
ambitious around what we could do.

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But to do that means we need to
scale the organisation far more

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efficiently and so that's where
my experience comes in alongside

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and very complementary to Jack's.

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That's really clear and
actually, as you describe it,

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I'm inclined to agree with you.

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It's hard to envisage that somebody
could focus on the day job.

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You said yourselves, you've only got
40 percent of the way through the

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portfolio, you've both been in situ
for five months, I think it is now,

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you know, it's a big portfolio, it's
a lot of work and so the idea you

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could do that and build a strategy
and scale, it sounds like a really

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good call that they've been split out.

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So in terms of building and scaling, why
is that such a large objective of yours?

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How have you come to that conclusion?

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And what are the benefits both for
your stakeholders, but also presumably

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for the university for that to happen?

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Yeah, so if I go back to the beginning
and in fact, this came out of my own

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due diligence on OSE before coming
in and I've come into this with my

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eyes wide open, as did Jack and we
had a lot of conversations over the

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summer before we started in September.

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What's clear is we are not touching the
sides of the container in terms of the

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scale of the opportunity and for all sorts
of reasons the organisation has been, and

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I'm not saying this as a criticism, it's
necessarily been a bit inward looking the

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last few years, but from conversations
we've both had and certainly I've had

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across the university and in departments
and within academics, there are a

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whole number of spin out opportunities
that we haven't even looked at.

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It's not a numbers game, without
compromising the quality of what we're

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trying to do, we could be doing a lot
more and to do a lot more, we need

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to be really clear about how we work.

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So one of the things that folks on
very early on, is to define what I call

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our operating model, how do we work?

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And to then think about that
operating model and all the different

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stages and how do we do each one?

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How do we address each of those
stages in a much more scalable way?

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Because I think there are many aspects
of what OSE is doing to level of

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excellence, but that excellence and
best practice isn't being run across the

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whole organisation necessarily in all
areas in a really clear and consistent

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way and that's where, actually, if we
want to go, you know, the opportunity

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is, you know, current plan, you know,
roughly, let's just say we're worth a

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billion, one billion and three now, the
current plan takes us to three billion.

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I think we need to be much
more ambitious than that.

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I think we could be doing
a hundred percent of that.

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We could be square brackets
working on a path now, how do we

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get to seven or eight billion?

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Yeah.

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But to do that, you know, this isn't
about doubling the headcounts and

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doubling the number of the companies
that we're investing in, but it is

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about doing what we do more efficiently
and that's where this comes in.

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But to be more efficient, we need
to really understand how do we work

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across all the different stages
of the sequence of what OSE does.

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So I will try and walk you
through this in the air.

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The elevator pitch.

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Yeah.

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So the first thing is we need
to maximise the number of high

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potential spin outs that we generate.

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So at the top of the funnel and there are
a number of departments in the university

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where we have really amazing engagement.

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Some of our team members are in there
regularly, at least once a week, coffees,

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walking the corridors, talking to the
academics, there's a, you know, really

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sort of vibrant level of discussion and
an idea generation, which is amazing.

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On the other end of the spectrum, there
are some departments we have zero contact

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with at all, despite the fact we've been
on the ground here, you know, we've got 55

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people, we've been here for eight years.

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So we can see there are some opportunities
and we need to think about how we

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better engage with those departments.

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So it can't be a cookie cutter approach.

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We need to think in some areas
and do we need to offer a prize?

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In other areas it might be more
effective to bring in some of the

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successful academics who work with
us who can come back and showcase

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by example what's possible.

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But in all cases what's really
important, again we might come on

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talk about this, is OSE needs to
be a lighthouse of inspiration.

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We have a very privileged
position here in Oxford and we

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should not take that for granted.

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We have a special relationship with the
university, but I would never want an

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academic to come to us and nor would
they off the base of the fact that we

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have an agreement with the university.

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I want people to come to us as the first
place they call because they have an idea

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of a business that they would consider
spinning out and they come to us because

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they can see the strength of our offering.

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So the first thing we need to do is we
need to improve our engagement across the

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university with, at the department level.

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to increase the top of the pipeline.

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Now, that is necessarily going to
mean we're going to say no to things.

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We can't back every single business.

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But I want to invest more at that
upfront stage and arguably, we're going

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to take some resource from the top
end of the business at the later stage

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and bring it back down to that early
stage, what we call sourcing phase.

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The second phase on the operating
model is then the venture building

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phase and what we need to do
here is we need to accelerate the

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speed at which we build companies.

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Again, just being very candid for a
very obvious good reasons, OSE's done

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a really good job actually of building
businesses, but we arguably stay in the

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build mode for a bit too long and it's
a really simple thing, we just need to

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have a clearer gate between the point
at which the company is self standing

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and good to go and we can then let go
and not sort of saying with a drift that

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we're sort of still building sort of
X years in because once we've built a

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standalone company, the measure of success
should be that maybe bar a seat on the

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board, we can step right back, job done.

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So I'll give you an example of that,
rather than us doing the hiring for

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the companies all the way through
the journey, we should be embedding

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people in the companies to do that
hiring more effectively themselves.

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How do we equip the companies
and the founding teams to build

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the company more efficiently and
effectively themselves rather than

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us doing all the heavy lifting?

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And I presume, sorry to interject, but
you know, there will be culture that is

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specific to those companies too, and if
you are too involved, you risk trying to

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make them homogenous or it by happening
by accident, not even trying and that

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whatever is unique about that founder,
might be a little bit diluted and that

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could actually have an impact on the
probability of success in itself and yeah.

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Absolutely and there's going to be a
phase right at the beginning, you know,

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we have one academic, we have some science
and you know, and a legal framework of

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a company and some IP, but that's it.

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So in the early days, we're going
to need to do that heavy lifting

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and helping build the team.

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And that's what somebody would expect
from a good investor, is help and

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guidance and advice, to a point.

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To a point and I think if we
were to look at this point in

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tangible terms, what does it mean?

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It means that actually we incentivise
the teams inside OSE that the success

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metric is the number of successful builds,
yeah, that we can create in a year,

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rather than it's somewhat open ended.

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So that's the second way,
we need to get that right.

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But I would say there's real excellence.

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I mean, one of the myths
around OSE, of which there are

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a number, is that we are...

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I've never heard any of them!

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Ok, sure.

222
00:13:19,625 --> 00:13:21,955
of them is that we're
an investor, full stop.

223
00:13:22,555 --> 00:13:25,360
We are an investor, but that
is a fraction of what we do.

224
00:13:25,790 --> 00:13:28,400
I set up my first business at Cambridge.

225
00:13:28,860 --> 00:13:33,320
There was no organisation like OSE and
frankly, if I had seen an OSE, I would

226
00:13:33,320 --> 00:13:38,240
have bitten the arm off the organisation
to do what we do, for free, to help

227
00:13:38,250 --> 00:13:40,300
our academics build their company.

228
00:13:40,300 --> 00:13:45,140
So this venture building phase, we find
the fractional CFO, we help put the EMI

229
00:13:45,140 --> 00:13:49,319
share option plan in, we get the lab
space, we find the chairman, sometimes we

230
00:13:49,320 --> 00:13:52,860
need to find the, I mean, it's a huge, we
make sure they've got two bank accounts

231
00:13:52,860 --> 00:13:56,279
rather than one bank account with SVB,
you know all these sorts of things.

232
00:13:56,510 --> 00:14:01,330
Yeah, there's a long list and that
takes 18 to 36 months of heavy lifting.

233
00:14:01,650 --> 00:14:05,909
So we do that well, but we know there's
more efficiency needed around it.

234
00:14:05,955 --> 00:14:09,235
The third phase is how do
we help our companies scale?

235
00:14:09,575 --> 00:14:12,365
Obviously, there's some overlap with
the venture building phase when we're

236
00:14:12,395 --> 00:14:14,315
thinking about scale then as well.

237
00:14:14,525 --> 00:14:17,145
But how do we manage that
scale phase more efficiently?

238
00:14:17,155 --> 00:14:22,014
And so this is where we move into more
of a portfolio management role and we

239
00:14:22,014 --> 00:14:25,870
need to think about how we manage a
sort of growing portfolio of companies

240
00:14:25,890 --> 00:14:30,520
in a more traditional sort of VC sort
of P manner where we've created the

241
00:14:30,520 --> 00:14:31,980
company and then we can step back.

242
00:14:31,980 --> 00:14:36,319
So I think there's some things we
need to think about and work on there.

243
00:14:37,510 --> 00:14:43,370
The fourth phase might initially
sound a bit outta place, but

244
00:14:43,370 --> 00:14:44,810
I think it's really important.

245
00:14:45,100 --> 00:14:49,390
We want our companies to impact
the world's greatest challenges.

246
00:14:49,480 --> 00:14:52,360
So if we go right back to the beginning,
we are looking for companies that

247
00:14:52,360 --> 00:14:56,020
have the potential to become billion
pound businesses and solve the world's

248
00:14:56,020 --> 00:15:00,580
greatest challenges and frankly, that's
why many of the team, if not everyone

249
00:15:00,580 --> 00:15:03,130
on the team comes into work and it's
partly why I've taken this role.

250
00:15:03,130 --> 00:15:08,610
It's a really inspiring mission that we
are explicit about internally and so on

251
00:15:08,610 --> 00:15:12,720
that journey, which sounds quite sort of
operational from finding the spin outs

252
00:15:12,720 --> 00:15:17,660
and venture building them and then manage
them in a scalable way, that's all great.

253
00:15:18,020 --> 00:15:22,519
But also we want to make sure we don't
lose sight of the fact that, you know,

254
00:15:22,549 --> 00:15:27,140
from an ESG perspective, but also from
a motivational point of view, we're also

255
00:15:27,189 --> 00:15:31,780
looking to create companies that have a
positive impact on the world and we need

256
00:15:31,780 --> 00:15:37,400
to get that right to drive the fifth
stage of the flywheel, which is we need

257
00:15:37,400 --> 00:15:39,490
to deliver returns for our shareholders.

258
00:15:40,000 --> 00:15:43,560
Obviously, we're an investment
business, yes, and we're all coming

259
00:15:43,560 --> 00:15:45,120
into work to make a difference.

260
00:15:45,480 --> 00:15:49,480
But at the end of the day, we also
have to deliver the best possible

261
00:15:49,480 --> 00:15:52,410
financial returns for our shareholders
and this is the stage where, you

262
00:15:52,449 --> 00:15:54,270
know, Jack really comes into his own.

263
00:15:54,640 --> 00:16:00,510
He is responsible with my and Jim
Wilkinson's support, the CFO, to maximise

264
00:16:00,530 --> 00:16:05,270
returns for our shareholders and the
sixth and final stage of the flywheel,

265
00:16:05,460 --> 00:16:11,910
I've gone sort of round the clock, is if
we get all of that right, then we help

266
00:16:12,470 --> 00:16:19,090
communicate the message that OSE is the
partner of first choice for academics

267
00:16:19,439 --> 00:16:24,260
and for investors and other stakeholders
that want to participate on this mission

268
00:16:24,700 --> 00:16:27,820
because if we get all of those things
right, then we become a very compelling

269
00:16:28,070 --> 00:16:33,210
partner to invest in, we've become a
really compelling partner to help grow

270
00:16:33,210 --> 00:16:39,250
your business and we become an exciting
place to work and that is the operating

271
00:16:39,250 --> 00:16:45,719
model and my job as CEO is, well, having
helped to define that is then now to

272
00:16:45,719 --> 00:16:50,110
build a strategy that then executes
on all of those different six areas.

273
00:16:50,200 --> 00:16:54,060
Thank you, that was very clear
and I imagine normally you have an

274
00:16:54,070 --> 00:16:55,340
infographic that helps you with that.

275
00:16:55,340 --> 00:16:57,170
I'm trying to, yeah, paint in the air!

276
00:16:57,380 --> 00:16:59,870
But hopefully it came across!

277
00:16:59,930 --> 00:17:00,430
Thank you.

278
00:17:00,430 --> 00:17:04,189
So at the end there you're talking
about the partner of choice and you've

279
00:17:04,190 --> 00:17:08,209
obviously bought an enormous amount
of money into Oxford university since

280
00:17:08,209 --> 00:17:13,020
inception in 2015, there's been a lot
of businesses that come out and you

281
00:17:13,020 --> 00:17:14,200
know, you have already built a lot.

282
00:17:14,220 --> 00:17:19,300
There's a lot of brilliant stuff that's
come out of OSE as an entity and yet,

283
00:17:19,550 --> 00:17:23,950
when you say partner of choice, you
are alluding to the fact that there

284
00:17:23,950 --> 00:17:28,879
is perhaps a little bit of a sentiment
among some, and I wouldn't say all

285
00:17:28,929 --> 00:17:33,830
by any stretch, that perhaps for some
reasons, that hasn't been the case and

286
00:17:33,830 --> 00:17:37,120
you alluded, you know, or you mentioned
outright, rather, some departments

287
00:17:37,120 --> 00:17:41,109
have been better interacted with than
others and they have borne more fruit,

288
00:17:41,149 --> 00:17:44,970
inevitably, maybe a better specialist,
maybe just personalities at play.

289
00:17:45,570 --> 00:17:49,410
But you also spoke earlier about  your
role as a founder, your empathy for

290
00:17:49,410 --> 00:17:53,840
the founders, the importance of being
involved, but then stepping back and it

291
00:17:53,840 --> 00:17:58,145
is candidly one of the, you know, if we
were to call them myths, but perhaps,

292
00:17:58,145 --> 00:18:02,655
you know, one could go further that
I have heard about OSE is that there

293
00:18:02,655 --> 00:18:07,405
is a propensity to sometimes have a
playbook, flip the founder out and the

294
00:18:07,405 --> 00:18:11,905
management team and clearly there's a few
things in there, one is the investment

295
00:18:11,905 --> 00:18:17,275
cycle that you yourselves are to a
degree answerable to as are all venture

296
00:18:17,275 --> 00:18:22,580
capital firms to a degree, but also
there is a risk that a really great

297
00:18:22,580 --> 00:18:26,590
founder might say, well I don't know,
they've got a bit of this reputation

298
00:18:27,030 --> 00:18:31,210
and so you've in part answered it, but I
would sort of name it out front because

299
00:18:31,590 --> 00:18:34,370
it is there to be overcome, I think.

300
00:18:34,945 --> 00:18:38,785
Yeah, it's a really important point
and look, I can relate to it on my

301
00:18:38,785 --> 00:18:43,315
own journey and you know, I think if I
think back to when I brought the first

302
00:18:43,335 --> 00:18:47,955
VC money onto my third business, I've
been through the journey twice and

303
00:18:47,955 --> 00:18:53,605
I'd seen it work well with one founder
and less well with another founder.

304
00:18:54,065 --> 00:18:56,014
So I'd seen some data points around this.

305
00:18:56,034 --> 00:18:59,175
Actually, I made a point with that VC
on the third business of saying to them

306
00:18:59,195 --> 00:19:04,160
when they came in, look, if at any point
you think I'm not the right CEO for this

307
00:19:04,160 --> 00:19:08,640
business, let's just sit down and have
a conversation, because the reality is,

308
00:19:08,760 --> 00:19:14,890
in most cases, the founding CEO is not
necessarily the same and best person

309
00:19:14,890 --> 00:19:18,720
to take it all the way through to exit
and if you look at OSE's journey, we've

310
00:19:18,720 --> 00:19:22,320
been on our own sort of startup journey
and you know, Dave Norwood, who I've had

311
00:19:22,320 --> 00:19:26,160
many conversations with in the run up to
taking the role, you know, he needed a

312
00:19:26,200 --> 00:19:30,950
particular energy to, you know, to really
get this off the ground and to knock

313
00:19:30,950 --> 00:19:36,550
some things together and so on, and to
have real vision, whereas arguably today,

314
00:19:36,960 --> 00:19:39,730
the role needs more operational focus.

315
00:19:39,730 --> 00:19:42,950
It's about scale and detail,
it's a different focus.

316
00:19:43,380 --> 00:19:45,950
So it's not a, there's no
implied criticism in this.

317
00:19:46,100 --> 00:19:51,960
So I think almost unapologetically, I
think as a responsible investor, when

318
00:19:51,960 --> 00:19:57,390
you're a custodian of other people's money
and in our case, that includes people's

319
00:19:57,420 --> 00:20:02,110
pension money, for example, but lots of
people's money, it's incumbent on us to

320
00:20:02,110 --> 00:20:07,280
make the right decisions for our companies
and sometimes that does mean we have to

321
00:20:07,280 --> 00:20:09,940
make some hard decisions and I say, I've
been on the receiving end of this, so

322
00:20:10,770 --> 00:20:14,570
I know what that's like and it's very
difficult when you've taken your baby and

323
00:20:14,760 --> 00:20:20,290
you've put your life, soul, everything
into it, it's a deep emotional attachment

324
00:20:20,300 --> 00:20:23,490
you have to the business that you've
taken from nothing to something, it's very

325
00:20:23,490 --> 00:20:29,480
difficult to step aside, but it's really
important that founders, me included, know

326
00:20:29,490 --> 00:20:31,160
when it's the right time to step aside.

327
00:20:31,200 --> 00:20:36,640
Now, having said all that, I think it's
also incumbent on OSE and other investors,

328
00:20:36,640 --> 00:20:40,180
particularly those of us, you know, we are
doing a very specific type of investment

329
00:20:40,180 --> 00:20:43,720
because we're investing right at the
beginning before there is a business.

330
00:20:44,270 --> 00:20:47,700
I really believe in transparency
internally and I have a

331
00:20:47,740 --> 00:20:50,730
sort of term called radical
transparency, which I try to adopt.

332
00:20:51,170 --> 00:20:55,195
But just on this, it's really important
we're transparent with our founders at

333
00:20:55,195 --> 00:20:59,425
the beginning and we say to them, look,
we might know at that point, you know,

334
00:20:59,425 --> 00:21:02,965
you could be an amazing chief science
officer or an amazing chief technology

335
00:21:02,965 --> 00:21:08,065
officer, but you know, candidly, we don't
think you've got the right skill set to

336
00:21:08,075 --> 00:21:12,245
be the CEO and if we know that at the
beginning, we need to be clear about that.

337
00:21:12,465 --> 00:21:14,415
Now it's a hard judgment
and maybe we don't know.

338
00:21:14,745 --> 00:21:17,535
It might be we say, look, we're really
happy to back you now, but we're going

339
00:21:17,535 --> 00:21:19,465
to need to review this in two years.

340
00:21:19,875 --> 00:21:24,395
So I think  those questions need to
be had in an open and transparent way

341
00:21:24,445 --> 00:21:29,075
and it's not a criticism because not
everyone is cut out for every single

342
00:21:29,075 --> 00:21:34,225
role in the building of a business and
people need to be highly self aware and

343
00:21:34,255 --> 00:21:40,265
open to feedback and guided to play to
their strengths for the interests of

344
00:21:40,265 --> 00:21:44,436
the whole team and the whole business
and by the way that includes OSE.

345
00:21:44,786 --> 00:21:47,705
So those are my thoughts on that,
but it's a question that's come

346
00:21:47,705 --> 00:21:50,695
up very close to my heart, a
number of times on my own journey.

347
00:21:50,850 --> 00:21:52,320
Yeah, that makes a lot of sense.

348
00:21:52,750 --> 00:21:57,170
One of the other kind of things that
one has heard over the years is that

349
00:21:57,170 --> 00:22:00,240
because we're this number one leading
university in Oxford and we've got all

350
00:22:00,240 --> 00:22:05,300
the great science that sometimes we have
given the impression to other investors

351
00:22:05,300 --> 00:22:09,585
that might want to come in and bring
capital to play here, sort of almost

352
00:22:09,585 --> 00:22:12,270
that we don't need them, which of course
is never going to be anyone's intent

353
00:22:12,290 --> 00:22:13,890
and couldn't be further from the truth.

354
00:22:14,330 --> 00:22:16,970
You've just talked about scaling,
clearly that would require more capital.

355
00:22:17,995 --> 00:22:21,645
But, you know, if those investors
hopefully might possibly be

356
00:22:21,645 --> 00:22:22,785
listening, what would you say?

357
00:22:22,785 --> 00:22:26,285
And in this role, how do you
view those investors coming in?

358
00:22:26,565 --> 00:22:30,755
I think the most important thing I can
say on this, just to be really clear,

359
00:22:30,895 --> 00:22:35,815
is we are open for business, full
stop and I can stop right there, but

360
00:22:36,185 --> 00:22:37,935
let me expand on why I'm saying that.

361
00:22:38,545 --> 00:22:44,700
I understand why there is a perception
that OSE is in some areas perceived

362
00:22:44,700 --> 00:22:48,360
as a gatekeeper, maybe even as
a blocker, to other investors

363
00:22:48,360 --> 00:22:50,030
coming into the ecosystem here.

364
00:22:50,480 --> 00:22:56,370
But I categorically can tell you
it is not true today and Jim and

365
00:22:56,370 --> 00:23:01,160
I are on a mission to really reset
the false narrative around this.

366
00:23:01,550 --> 00:23:03,900
But let's just go back because
it hasn't come from nowhere.

367
00:23:04,550 --> 00:23:09,430
It's come from a time, I think, in the
early days of OSE when, you know, it was

368
00:23:09,520 --> 00:23:15,660
for sure the key, biggest, only major
player on the ground in this area in

369
00:23:15,660 --> 00:23:20,135
Oxford and it had an approach where it
was looking to do a hundred percent of

370
00:23:20,135 --> 00:23:22,335
every single spin out that came out.

371
00:23:22,835 --> 00:23:25,815
That is not the case today and
hasn't been for the last few years.

372
00:23:26,235 --> 00:23:29,045
I've asked my team because I've
had this fed back to me a number

373
00:23:29,045 --> 00:23:30,825
of times in the first five months.

374
00:23:31,375 --> 00:23:32,925
The numbers speak for themselves.

375
00:23:33,365 --> 00:23:38,745
We've invested approaching a billion
pounds in Oxford in the last eight years.

376
00:23:39,405 --> 00:23:45,415
We have now leveraged another billion on
top, so two billion pounds that we've put

377
00:23:45,415 --> 00:23:50,935
into Oxford University spin outs, that
other billion has come from north of 300

378
00:23:50,975 --> 00:23:55,315
co investors who we have brought into
the ecosystem to invest alongside us.

379
00:23:55,835 --> 00:24:00,005
We had a deep tech event in London a
couple of weeks ago where we wanted to

380
00:24:00,005 --> 00:24:04,005
showcase some of the really exciting
companies in the deep tech portfolio.

381
00:24:04,345 --> 00:24:10,770
We had 140 investors, attendees
at that event and we're doing this

382
00:24:10,830 --> 00:24:17,100
because number one, it makes total
economic sense for us to share the

383
00:24:17,100 --> 00:24:19,000
load of what we're trying to do.

384
00:24:19,000 --> 00:24:21,540
We cannot do this and do not
want to do this on our own.

385
00:24:21,770 --> 00:24:25,940
We don't want to be sat owning 100 percent
of every single company in our portfolio.

386
00:24:26,150 --> 00:24:31,230
We want to bring in smart investment
capital to sit alongside us, to support

387
00:24:31,230 --> 00:24:33,510
us and support our companies financially.

388
00:24:33,745 --> 00:24:37,585
But also to validate the theses of
our investments, many of the companies

389
00:24:37,585 --> 00:24:41,065
we're investing are doing things that
have never been done before and so

390
00:24:41,095 --> 00:24:45,905
the more brains and smart capital
we have alongside us, the better.

391
00:24:46,355 --> 00:24:51,765
So I say, I can see where it's come
from, but we actively want more

392
00:24:51,765 --> 00:24:53,775
investors in the ecosystem here.

393
00:24:54,145 --> 00:25:00,115
The challenge we've got now, and I'm
saying this in a, OSE has 55 people

394
00:25:00,155 --> 00:25:06,235
on the ground here, just numerically
we've invested in more people, in

395
00:25:06,235 --> 00:25:10,575
more departments, we're sponsoring
more courses, more PhDs, I mean, we're

396
00:25:10,575 --> 00:25:15,525
spending millions just in the ecosystem
here and so we are very present and

397
00:25:15,985 --> 00:25:19,980
there will be some Investors who don't
want to get on the 50 minute train

398
00:25:20,000 --> 00:25:24,390
from Paddington to Oxford, but frankly,
they're missing out and from our point

399
00:25:24,390 --> 00:25:25,500
of view, we would love to see them.

400
00:25:25,500 --> 00:25:26,790
We'd love to have them here.

401
00:25:27,170 --> 00:25:31,460
But, I think we, you know, we should be
confidently saying that we collectively,

402
00:25:31,480 --> 00:25:37,560
as in the university and OSE, OUI, we've
built something really incredible in OSE.

403
00:25:37,940 --> 00:25:41,110
We believe we are the largest
venture builder of spin outs

404
00:25:41,150 --> 00:25:42,500
outside the United States.

405
00:25:42,500 --> 00:25:46,050
That's something we should be really proud
of and if you just look at the capital we

406
00:25:46,050 --> 00:25:51,000
brought in, it far outstrips anything else
across Europe and so I say we should be

407
00:25:51,000 --> 00:25:55,620
really proud of that and we're saying that
with a view to how do we use that success

408
00:25:56,020 --> 00:26:00,990
to be a magnet to bring in even more
capital than we currently have and that's

409
00:26:00,990 --> 00:26:05,760
what I say we're on a mission to sort of
course correct in terms of the narrative.

410
00:26:06,500 --> 00:26:09,250
Okay, so I'm going to lay the final
one out for you Ed, because you know,

411
00:26:09,310 --> 00:26:11,420
we're on a roll now, killing the myths.

412
00:26:11,630 --> 00:26:14,390
One of the other things that I have
sometimes heard, and I'm sure you have,

413
00:26:14,420 --> 00:26:18,390
and to be honest, it's now sort of been
brought to the fore by, you know, Irene

414
00:26:18,390 --> 00:26:21,840
Tracey being a co author of the spin
out review and one of the things that

415
00:26:21,840 --> 00:26:26,335
was in there was equity stakes and have
historically heard that, you know, the

416
00:26:26,335 --> 00:26:31,255
perception was that the equity stakes
taken by Oxford and by extension by OSE

417
00:26:31,275 --> 00:26:35,765
in many cases was too large and that
was having a dampening effect on other

418
00:26:35,995 --> 00:26:39,955
great investors that you just alluded
to wanting to have alongside for all

419
00:26:39,965 --> 00:26:43,745
of the great signaling and you know
what they can bring in their networks.

420
00:26:44,115 --> 00:26:48,105
So what would you say to that
particular sort of perception?

421
00:26:48,460 --> 00:26:52,650
Well, I think the consensus of the
review was that actually we've landed

422
00:26:52,660 --> 00:26:59,080
in exactly the right place in so far as
the university has a 20 percent position

423
00:26:59,130 --> 00:27:05,450
in spin outs that include IP that has
been somehow, some form funded by the

424
00:27:05,450 --> 00:27:11,350
university and again, historically, it
was a bigger percentage and so you can

425
00:27:11,350 --> 00:27:15,350
see where it's come from, but I think
everyone, no, well, it's not everybody,

426
00:27:15,630 --> 00:27:19,270
most people I'm talking to think that's,
you know, bearing in mind the maturity

427
00:27:19,270 --> 00:27:22,860
of the ecosystem here, most people
feel that's about the right balance.

428
00:27:22,870 --> 00:27:27,560
So the founders have 80 percent and
the university, based off its ownership

429
00:27:27,560 --> 00:27:33,890
of the IP, lands at 20% and that model
is, and that template has, is being

430
00:27:33,890 --> 00:27:38,840
followed by Northern Gritstone in
Manchester, by Midlands Mineforge and

431
00:27:38,850 --> 00:27:42,690
others, I gather even in Australia,
they're copying the same template.

432
00:27:43,060 --> 00:27:45,960
I feel relatively comfortable,
and most of the people I'm

433
00:27:45,960 --> 00:27:47,280
talking to feel it's about right.

434
00:27:47,730 --> 00:27:53,000
Now, when we're maybe at the level of
MIT and you know, this flywheel is just

435
00:27:53,280 --> 00:27:57,220
throwing off spin outs and you know,
there's an enormous amount of money coming

436
00:27:57,220 --> 00:28:01,370
back into the University Endowment Fund
and the College Endowment Fund, maybe

437
00:28:01,370 --> 00:28:04,700
we can take another look at it, but
we're not there yet, we're not close.

438
00:28:04,740 --> 00:28:08,400
Now our ambition and my ambition with
OSE is we get it to that sort of level,

439
00:28:08,850 --> 00:28:10,650
but that is not where we are right now.

440
00:28:10,650 --> 00:28:14,060
So I think over time we need to, we might
need to review it again, but I think

441
00:28:14,060 --> 00:28:15,460
it's about right for where we are now.

442
00:28:15,860 --> 00:28:16,830
Perfect, thank you.

443
00:28:17,300 --> 00:28:22,700
So talking about MIT and Institutes of
Technology, how do you think the Ellison

444
00:28:22,730 --> 00:28:26,880
Institute for Technology is going to
impact Oxford and what's your view?

445
00:28:27,205 --> 00:28:32,865
Well, I mean, I think, it's an incredible
stamp of approval and validation on the

446
00:28:32,865 --> 00:28:37,375
quality of the science that's here and I
think that's just a, you know, a massive

447
00:28:37,375 --> 00:28:42,755
tick in the box for Oxford in the broadest
sense and you know it's exciting, again

448
00:28:42,755 --> 00:28:49,265
it's just the sense that Larry Ellison has
picked Oxford for this and is investing

449
00:28:49,265 --> 00:28:55,015
a significant amount of capital in Oxford
to create something so exciting, I think

450
00:28:55,025 --> 00:29:01,445
just speaks to, and I'm saying this as
a Cambridge graduate, speaks to what is

451
00:29:01,495 --> 00:29:07,405
actually really special about Oxford and
why, when I look at just the mind blowing

452
00:29:07,405 --> 00:29:12,505
science that's coming out of the labs
that we're seeing, that we're turning

453
00:29:12,505 --> 00:29:14,335
into companies that will change the world.

454
00:29:14,515 --> 00:29:19,305
I can see why he's chosen Oxford and
I think it just reinforces the, power

455
00:29:19,305 --> 00:29:23,015
of the ecosystem and the brand that we
have here, which is globally recognised.

456
00:29:23,035 --> 00:29:26,845
I mean, essentially, if you look at our
cap table, a significant proportion of

457
00:29:26,845 --> 00:29:31,845
our investors come from outside the UK
and the draw is the Oxford brand, the

458
00:29:31,845 --> 00:29:35,725
quality of the science and the quality
of the companies that are coming out

459
00:29:35,735 --> 00:29:37,340
of the ecosystem off the back of that.

460
00:29:37,650 --> 00:29:41,030
Yeah, really interesting and
you spoke about your experience

461
00:29:41,030 --> 00:29:42,090
in government earlier.

462
00:29:42,300 --> 00:29:45,250
What are the interactions that
you're having on that front

463
00:29:45,290 --> 00:29:46,880
at the moment in your role?

464
00:29:48,010 --> 00:29:50,160
So I guess there are a couple of themes.

465
00:29:50,770 --> 00:29:54,980
So I'm talking, I'm on different
round tables, sort of up to a

466
00:29:55,000 --> 00:29:58,650
ministerial level, I was in 10
Downing Street a couple of months ago.

467
00:29:59,060 --> 00:30:04,510
I think there's a few themes to this and
it's a dialogue that's work in progress.

468
00:30:04,510 --> 00:30:13,110
But one of the themes is that I truly
believe that the university science

469
00:30:14,270 --> 00:30:20,560
ecosystems that we are building here in
the UK are a national asset and I want to

470
00:30:20,580 --> 00:30:24,760
challenge the awareness of this because
I think we're sat on, if I quote somebody

471
00:30:25,110 --> 00:30:30,310
who's taken a look at our portfolio,
we're sat on their equivalent of Gulf Oil.

472
00:30:30,840 --> 00:30:35,375
There are very few countries that
dominate, well we dominate the

473
00:30:35,375 --> 00:30:38,685
university league table and if you
look at the science and the spin

474
00:30:38,685 --> 00:30:40,745
outs coming out, it is world class.

475
00:30:41,175 --> 00:30:47,085
So I don't think there is as widespread
understanding, sort of more nationally,

476
00:30:47,345 --> 00:30:52,375
around how valuable this is as an asset
to the whole country, so that's one thing.

477
00:30:52,565 --> 00:30:56,355
I can see that's understood at a
senior level in government, but I think

478
00:30:56,355 --> 00:31:00,505
we could do more to really amplify
how valuable this is to everybody.

479
00:31:00,735 --> 00:31:03,055
Well, but it's only
valuable if we keep it here.

480
00:31:03,355 --> 00:31:05,835
And that's my second point!

481
00:31:05,865 --> 00:31:09,275
And there are different schools of thought
on this and I do understand at some

482
00:31:09,275 --> 00:31:11,955
point, you know, you need to follow the
money and follow where the returns are.

483
00:31:12,435 --> 00:31:17,665
But my second challenge is, and I'm
watching this sort of ringside seats.

484
00:31:18,325 --> 00:31:23,675
We, as in not just OSE, but others, are
doing an incredible job taking the most

485
00:31:23,675 --> 00:31:28,105
advanced science on the planet, going
through all the hard yards and pain of

486
00:31:28,105 --> 00:31:32,895
building a self standing company, raising
considerable amounts of capital and then

487
00:31:32,895 --> 00:31:38,635
we catapult it out of the UK, to list
somewhere on NASDAQ or somewhere else and

488
00:31:38,645 --> 00:31:42,875
look, that's in and of itself, that's not
a bad thing and you get good valuations

489
00:31:42,875 --> 00:31:48,140
and so on, but some of our companies are
critical to the national interest, they're

490
00:31:48,140 --> 00:31:53,840
strategically valuable to the UK and so
again, I just want to just challenge, I'm

491
00:31:53,840 --> 00:31:55,340
not saying it's the wrong thing to do.

492
00:31:55,340 --> 00:32:00,270
I just want to challenge the,
status quo because right now that

493
00:32:00,270 --> 00:32:04,190
is almost the default conveyor belt.

494
00:32:04,710 --> 00:32:10,010
We build the business, we invest in it and
then we launch it off into another market

495
00:32:10,080 --> 00:32:14,830
and then when the big liquidity event
happens, I know the listing or whatever,

496
00:32:15,210 --> 00:32:20,560
that capital, the flow of that capital,
then cascades down somewhere else and what

497
00:32:20,560 --> 00:32:26,600
we need to then inspire and capitalise the
next generation of entrepreneurs, which is

498
00:32:26,600 --> 00:32:30,420
why the US has been so successful, we need
that to happen in Oxford, in Cambridge

499
00:32:30,430 --> 00:32:35,100
and in Manchester and Leeds and Sheffield,
that's where we need to have it and so

500
00:32:35,130 --> 00:32:37,170
that we can start recycling that capital.

501
00:32:37,650 --> 00:32:41,220
So that's my second challenge, I think
there's more around skills and so on,

502
00:32:41,220 --> 00:32:42,910
but I think those are the two big themes.

503
00:32:43,060 --> 00:32:47,190
Yeah, no, it's really interesting and I've
had, you know, in projects I've worked on

504
00:32:47,270 --> 00:32:54,080
discussions with government and you know,
in particular focused on scale up capital

505
00:32:54,080 --> 00:32:58,670
that companies need and where there's a
real drop off in domestic capital and it's

506
00:32:58,670 --> 00:33:03,159
an interesting question because domestic
capital clearly keeps companies in the UK.

507
00:33:03,310 --> 00:33:05,750
But you've got international
capital, but you're domestically

508
00:33:05,750 --> 00:33:07,080
based, so that can work too.

509
00:33:07,080 --> 00:33:09,460
It doesn't have to mutually exclusive.

510
00:33:09,460 --> 00:33:10,560
Yeah, absolutely.

511
00:33:10,860 --> 00:33:15,150
But you know, actually one of our guests
previously was Alderman Nicholas Lyons,

512
00:33:15,160 --> 00:33:18,880
who was the Lord Mayor that brought
across the Mansion House Compact and

513
00:33:19,200 --> 00:33:22,660
very successfully getting defined
contribution pension plans to commit

514
00:33:22,660 --> 00:33:28,420
to 5 percent in unlisted by 2030,
which will be a huge amount of money.

515
00:33:28,905 --> 00:33:31,635
How do you see that playing
into these problems?

516
00:33:31,915 --> 00:33:33,415
Are you looking to capture
some of that money?

517
00:33:33,415 --> 00:33:33,735
Are you..?

518
00:33:33,890 --> 00:33:39,460
Absolutely and so by the way, when I say
I just want to raise this, it's to be fair

519
00:33:39,460 --> 00:33:41,080
to the people I'm speaking in government.

520
00:33:41,100 --> 00:33:44,860
I'm preaching to the converted by
the way, so this is not new news.

521
00:33:45,310 --> 00:33:47,615
They're they're quite good
at agreeing and maybe...

522
00:33:47,900 --> 00:33:52,310
I'm giving a live example of, the
implications of this not being the case

523
00:33:52,310 --> 00:33:56,630
right now, because I'm saying we're
watching this live with some really

524
00:33:56,690 --> 00:34:03,150
exciting, globally unique companies
looking at moving,  their headquarters

525
00:34:03,160 --> 00:34:05,210
out of the UK to other countries.

526
00:34:05,210 --> 00:34:06,280
So the momentum is not
in the right direction.

527
00:34:06,300 --> 00:34:07,690
It's not in the right direction.

528
00:34:07,720 --> 00:34:10,060
So I think the government
understands this.

529
00:34:10,370 --> 00:34:14,910
I think the mansion house compact is
really, it's really encouraging, you know,

530
00:34:14,910 --> 00:34:16,680
in our world, five years is a long time.

531
00:34:17,625 --> 00:34:22,225
Okay, so I think if we can work, we
collectively can work this through,

532
00:34:22,235 --> 00:34:25,565
it'd be, it would be a good, there's
clearly a significant pool of capital

533
00:34:25,805 --> 00:34:31,115
and yes, we have conversations running
as well with pension funds and hopefully

534
00:34:31,115 --> 00:34:33,175
we can fast track some of that process.

535
00:34:33,495 --> 00:34:39,585
But this process needs to work because
it's a critical missing piece right

536
00:34:39,585 --> 00:34:45,235
now and we have, the capital is sat
there and if we can unlock it in

537
00:34:45,245 --> 00:34:48,500
the way that it, what we're talking
about that could solve some of these

538
00:34:48,500 --> 00:34:50,880
issues, it could be a game changer.

539
00:34:51,090 --> 00:34:54,480
So there's a bit of me that's really
excited about it, but as I say,

540
00:34:54,480 --> 00:34:56,890
five, six years is a long wait.

541
00:34:56,890 --> 00:35:00,670
So I'm really hoping that, you know, we'll
get some movement on that within that

542
00:35:00,670 --> 00:35:04,810
timeframe rather than we have to wait
till 2030 to see the first funds flowing.

543
00:35:05,115 --> 00:35:06,735
Yeah, I couldn't agree more.

544
00:35:07,155 --> 00:35:10,555
It's four trillion nearly, that we've
got in pension capital and less than

545
00:35:10,555 --> 00:35:14,995
one percent invested and so I think the
government are slightly hamstrung by

546
00:35:14,995 --> 00:35:20,660
the financial circumstance but you know,
tax breaks, UK ISAs, encouraging our

547
00:35:20,660 --> 00:35:24,830
own pension funds to invest, all these
seem like, you know, low hanging fruit.

548
00:35:25,610 --> 00:35:27,650
So that's exciting, hopefully.

549
00:35:28,280 --> 00:35:30,000
Well, listen, thank you so much, Ed.

550
00:35:30,010 --> 00:35:34,060
You've been really candid and open, and
I hope you don't mind me sort of throwing

551
00:35:34,060 --> 00:35:36,660
you the sacred cows to kill, as it were.

552
00:35:37,280 --> 00:35:40,980
Is there anything else that you kind
of particularly wanted to have as a

553
00:35:40,990 --> 00:35:43,200
parting thought for anyone listening?

554
00:35:43,810 --> 00:35:48,130
First of all, thanks to you for giving
me the opportunity to share my thoughts.

555
00:35:48,380 --> 00:35:53,540
My approach is always to be very
candid, I think that's really the only

556
00:35:53,540 --> 00:35:55,710
way, not everyone's going to agree.

557
00:35:56,130 --> 00:36:02,365
But I guess probably all I would say
is, I genuinely believe that we have

558
00:36:02,365 --> 00:36:04,325
something quite remarkable here.

559
00:36:04,485 --> 00:36:08,165
I want to say we have, what we
have is not just OSE, we have an

560
00:36:08,175 --> 00:36:12,315
ecosystem with the most incredible
science, with some really incredible

561
00:36:12,315 --> 00:36:15,405
talent and the capital and a brand.

562
00:36:15,765 --> 00:36:20,975
We have all the ingredients to build
something amazing and I'm determined

563
00:36:20,995 --> 00:36:26,305
to make that happen and I guess my ask
of people in the ecosystem is please

564
00:36:26,305 --> 00:36:32,315
help, please help us, because the more
of us that can get behind this endeavor,

565
00:36:32,635 --> 00:36:36,925
broader than building OSE, but build the
endeavor of building a really exciting

566
00:36:37,385 --> 00:36:39,955
ecosystem around this, the better.

567
00:36:40,475 --> 00:36:44,395
That's probably one thing and the second
thing is, you know, inevitably when you're

568
00:36:44,405 --> 00:36:48,165
trying to do something new, you're going
to misstep and there's going to be some

569
00:36:48,165 --> 00:36:54,065
trip ups along the way and in the same
way I am candid in what I say, I'm also

570
00:36:54,065 --> 00:37:02,175
very open and approachable on feedback and
I really encourage anyone who, if there

571
00:37:02,175 --> 00:37:06,440
are any missteps on our part or issues
that, you know, people just call me.

572
00:37:07,835 --> 00:37:08,465
Come and tell me.

573
00:37:08,515 --> 00:37:10,625
I'm interested to understand
where can we do better?

574
00:37:11,215 --> 00:37:12,445
What could we do differently?

575
00:37:12,515 --> 00:37:16,795
I am just interested in building
something incredible and the more I

576
00:37:16,795 --> 00:37:20,055
can learn from where we're getting
things wrong, as well as things right,

577
00:37:20,125 --> 00:37:22,285
the more likely we can be successful.

578
00:37:22,595 --> 00:37:26,505
Thank you, I'm sure that will be well
received and thank you so much for

579
00:37:26,505 --> 00:37:30,305
your time and your candor Thanks for
listening to this episode of Oxford+

580
00:37:30,655 --> 00:37:32,465
presented by me, Susannah de Jager.

581
00:37:32,945 --> 00:37:36,355
If you want to stay up to date with all
things Oxford+, please visit our website

582
00:37:36,405 --> 00:37:41,175
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583
00:37:41,785 --> 00:37:44,965
Oxford+ was made in partnership
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584
00:37:44,965 --> 00:37:51,975
and edited by Story Ninety-Four.