Precision Hormone Health: Testosterone, Menopause, Muscle, Sleep, and Proactive Longevity: Endocrinologist Dr. Florence Comite details her book “
Invincible: Defy Your Genetic Destiny to Live Better, Longer” and her precision-medicine approach to proactive longevity. She discusses testosterone decline beginning in the 30s in both sexes, stress-related low T (including in special forces), and testosterone’s roles in energy, cognition, motivation, muscle, bone, and chronic disease risk. Comite argues genes are a “draft” and health destiny can be altered through epigenetic-like choices, individualized data, and early monitoring. For women, she emphasizes estrogen, progesterone, and testosterone in perimenopause/menopause, preferring bioidentical hormones and criticizing WHI’s use of Premarin/Provera and older participants. She covers osteoporosis prevention, muscle as an “organ of longevity,” protein intake, resistance training, continuous glucose monitors for individualized diet, sleep quality tracking via wearables, and selective use of DHEA, pregnenolone, growth hormone pathways, and peptides with attention to sourcing and risk.