Proteomics in Proximity

In this episode we discuss a paper titled "Chromatin Remodeling in Response to BRCA2-Crisis" by Dr. Michael Snyder's Stanford laboratory, that tells an interesting multi-omics story of how the BRCA2 inherited cancer gene has multiple functions.

Show Notes

The 2019 Cell Reports paper, “Chromatin Remodeling in Response to BRCA2-Crisis” by J Gruber and M Snyder et al. is available online here.

Dr. Michael Snyder’s Stanford laboratory home page is here.

A 1998 Oncogene paper, “The BRCA2 is a histone acetyltransferase” by S Habibur and E S P Reddy et al. is located online here. A 2014 Cancer Discovery paper, “R-loop Processing by BRCA2 is Required for Genomic Stability” is located here. And more about TIP60 can be found in this recent 2022 Oncogenesis reference, “The TIP60-ATM axis regulates replication fork stability in BRCA-deficient cells” located online here. 

If you would like to contact Dale, Cindy or Sarantis feel free to email us at info@olink.com and if you would like to learn more about our backgrounds, Cindy’s LinkedIn is here, Sarantis’ is here, and Dale’s is here.

In case you were wondering, Proteomics in Proximity refers to the principle underlying Olink Proteomics assay technology called the Proximity Extension Assay (PEA), and more information about the assay and how it works can be found here.

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What is Proteomics in Proximity?

Proteomics in Proximity discusses the intersection of proteomics with genomics for drug target discovery, the application of proteomics to reveal disease biomarkers, and current trends in using proteomics to unlock biological mechanisms. Co-hosted by Olink's Dale Yuzuki, Cindy Lawley and Sarantis Chlamydas.