Wiring Matters: Why the Same Brain Stimulation Helps Some Depression and Not Others

Wiring Matters: Why the Same Brain Stimulation Helps Some Depression and Not Others

A Nature Communications study of 51 people with treatment-resistant depression receiving subcallosal cingulate deep brain stimulation found that how much of two specific white matter bundles was stimulated — and the integrity of those tracts — predicted who improved over 24 weeks.

Source

Toward personalized deep brain stimulation via white matter stimulation and microstructure in depression — Nature Communications, published November 10, 2026 — Song, Choi, Figee, Mayberg and colleagues, Mount Sinai / Emory

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