Intelligent Medicine | The Best of High Tech Medicine and Alternative Modalities

What Triggers Age-Related Belly Fat? New Stem Cell Findings and a Nutrition Perspective: Nutritionist Leyla Muedin discusses research from City of Hope (published in Science) on why belly fat increases with age even without major weight gain, emphasizing the health risks of visceral fat as an endocrine organ linked to inflammation, diabetes, heart disease, and accelerated aging. The study suggests aging activates adipocyte progenitor cells (APCs) and produces an age-specific stem cell population called committed preadipocytes (CP-As) that generate new fat cells, with experiments showing older APCs create more fat cells even when transplanted into young mice. Single-cell RNA sequencing identified greater CP-A activity in middle-aged mice and similar cells in higher numbers in middle-aged human tissue. Researchers implicate the LIFR signaling pathway and propose future therapies to block these cells, while Leyla questions root causes and argues metabolic dysfunction—insulin resistance, hyperinsulinemia, high carbohydrate intake, and sedentary behavior—should be addressed nutritionally rather than via a pill.

Creators and Guests

LC
Host
Leyla Muedin, MS, RD, CDN
Leyla has been a practicing nutritionist since 2003, when she started under the tutelage of the famed Dr. Robert Atkins at the Atkins Center for Complementary Medicine. Since 2005, she has worked alongside Dr. Hoffman at the Hoffman Center and then in private practice.

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Pioneering complementary medicine practitioner Dr. Ronald Hoffman takes a cutting-edge approach to health, wellness, and aging. He covers both conventional and alternative modalities, as well as nutrition, exercise, and supplements.