Episode 25. Managing Acute Toxicities of CAR T-cell Therapy

In this episode, we discuss the management of acute toxicities of CAR T-cell therapy, including CRS, ICANS, and HLH with Dr. Michael Jain from Moffitt Cancer Center.

Here are some of the key articles we discussed:

1. “How I treat refractory CRS and ICANS after CAR T-cell therapy”. 

     https://pubmed.ncbi.nlm.nih.gov/36989488/

 

2. CAR-HEMATOTOX score: 

    https://pubmed.ncbi.nlm.nih.gov/34166502/

 

3. “How I treat cytopenias after CAR T-cell therapy”.

     https://pubmed.ncbi.nlm.nih.gov/36800563/

 

4. Immune Effector Cell-Associated HLH-Like Syndrome (ASTCT):

    https://pubmed.ncbi.nlm.nih.gov/36906275/

 

5. ASTCT consensus grading for CRS and ICANS:

    https://pubmed.ncbi.nlm.nih.gov/30592986/

6. Hematopoietic stem cell boost for persistent neutropenia after CAR T-cell therapy:

    https://pubmed.ncbi.nlm.nih.gov/35696759/

 

7. Modified EASIX score for predicting CRS and neurotoxicity:

    https://pubmed.ncbi.nlm.nih.gov/34432870/

What is Blood Cancer Talks?

This is a podcast on latest advances in the understanding and management of blood cancers. Here, we will bring a wide range of experts within hematologic malignancies to discuss various topics in depth.
Host: Raj Chakraborty, MD from Columbia University, New York, Ashwin Kishtagari, MD, from Vanderbilt University, Nashville, and Edward Cliff, MD, from Harvard University, Boston
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