Thomas N. Seyfried is Professor of Biology at Boston College, and received his Ph.D. in Genetics and Biochemistry from the University of Illinois, Urbana, in 1976. He did his undergraduate work at the University of New England and holds a Master's degree in Genetics from Illinois State University, Normal, IL. He was a Postdoctoral Fellow & Assistant Professor in the Neurology Dept. at the Yale University School of Medicine. He presently serves on several editorial boards, including those for Nutrition & Metabolism, Neurochemical Research, the Journal of Lipid Research, and ASN Neuro, where he is a Senior Editor. Dr. Seyfried has over 200 peer reviewed publications and is author of the book, Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer (Wiley Press). His book was recently translated into Chinese and is now under contract for translation into Turkish. His full list of peer-reviewed publications can be found on PubMed.
Dr. Seyfried’s X account:
Show Notes
In this episode, we cover the following:
- Cancer is driven by defective energy metabolism, not genetic mutations.
- All major cancers share the same core problem: dysfunctional mitochondria.
- The Warburg Effect shows cancer cells use fermentation even in the presence of oxygen.
- Cancer triggers are diverse but all link to mitochondrial failure (the oncogenic paradox).
- Oxygen consumed by cancer cells is not used for efficient energy production.
- Ketogenic diets and glutamine targeting can starve cancer cells.
- Metabolic therapy applies broadly across most cancer types.
- Seed oils likely contribute to mitochondrial damage and chronic disease.
- We have significant control over cancer risk through diet and lifestyle.
- The idea that meat causes cancer is likely overstated and not well-supported.
- How cancer spreads.
- Rising cancer rates in young people.
- Future cancer management should shift toward metabolic therapies over genetic treatments.
- Seyfried encourages future doctors to question dogma and focus on energy metabolism.
[Disclaimer: All health and nutritional information on this podcast should not take place of medical or professional advice. Although I am a medical doctor, I am not your healthcare provider. This episode is for informational and educational purposes only and should not substitute the advice from your healthcare professional. Always consult with your physician / healthcare provider prior to making any exercise, dietary, medical, or lifestyle decisions. Those who do not seek counsel from the appropriate healthcare provider assume the liability of any injury / adverse events which may occur. Do not follow the advice in this episode if you do not wish to be bound by this disclaimer.]
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I am a medical doctor, certified pre-/postnatal trainer, and a mother of four, and I am on a mission to empower moms to be strong, healthy, and happy throughout all stages of motherhood. - Navigating the world of health information, even with my medical expertise, has often felt like wading through a sea of misleading information and confusion. My mission is clear: to lead and inspire a healthy lifestyle across all life's stages by delivering actionable, evidence-based insights.
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