Episode 17. Acquired Aplastic Anemia

In this episode, we discuss the management of acquired aplastic anemia with Dr. Amy DeZern. Here are the links to some of the key articles discussed in this show:

1. Review article on aplastic anemia: 

https://www.nejm.org/doi/10.1056/NEJMra1413485

 

2. RCTs testing whether addition of cyclosporine to ATG improves outcomes in aplastic anemia:

https://www.nejm.org/doi/10.1056/NEJM199105093241901

https://www.sciencedirect.com/science/article/pii/S0006497120489748

 

3. RCT testing horse versus rabbit ATG in aplastic anemia:

https://www.nejm.org/doi/full/10.1056/nejmoa1103975

 

4. Single-arm study of eltrombopag in addition to standard immunosuppressive therapy in aplastic anemia: 

https://www.nejm.org/doi/10.1056/NEJMoa1613878

 

5. Long-term follow up of patients treated with immunosuppressive therapy and eltrombopag:

https://ashpublications.org/blood/article/139/1/34/476916

 

6. RACE Trial: Standard immunosuppressive therapy +/- eltrombopag in aplastic anemia:

https://www.nejm.org/doi/10.1056/NEJMoa2109965

 

7. Clinical and molecular determinants of clonal evolution in patients with aplastic anemia:

https://ascopubs.org/doi/abs/10.1200/JCO.22.00710

What is Blood Cancer Talks?

This is a podcast on latest advances in the understanding and management of blood cancers. Here, we will bring a wide range of experts within hematologic malignancies to discuss various topics in depth.
Host: Raj Chakraborty, MD from Columbia University, New York, Ashwin Kishtagari, MD, from Vanderbilt University, Nashville, and Edward Cliff, MD, from Harvard University, Boston
Tweet your suggestions and feedback to @rajshekharucms @AshKishtagari @Eddie_Cliff @BloodCancerTalk