Welcome to Episode 2 of From Bench to Bedside where we explore the history of disease and scientific advancements leading to treatments. In this episode host Dr. Melanie Matheu (PhD) provides an introduction to the history Diabetes Mellitus, the critical advances that led us to the treatments of today, and what is next.
Corrections:
- GLUT4 is a glucose transporter (it was called a receptor).
- Tidepool’s app for monitoring glucose was cleared by the FDA earlier this year (2023).
Biotech Companies, Resources, and Start-ups of Interest
References:
- International Diabetes Federation https://diabetesatlas.org/
- Quantifying the underestimation of projected global diabetes prevalence by the International Diabetes Federation (IDF) Diabetes Atlas Tonnies, T et al. BMJ Open Diabetes Research & Care, 2021 https://drc.bmj.com/content/9/1/e002122
- Milestones in the history of diabetes mellitus: The main contributorsKaramanou, M et al. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707300/
- Aretaeus of Cappadocia (2nd century AD) and the earliest neurological descriptions https://pubmed.ncbi.nlm.nih.gov/19291658/
- A history of diabetes mellitus or how a disease of the kidneys evolved into a kidney disease Eknoyan, G., Nagy J. https://pubmed.ncbi.nlm.nih.gov/15822058/
- Making, Cloning, and the Expression of Human Insulin Genes in Bacteria: The Path to Humulin Arthur D Riggs https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8152450/
- The History of a Wonderful Thing We Call Insulin https://diabetes.org/blog/history-wonderful-thing-we-call-insulin#
- Regulation of glucose transport by insulin: traffic control of GLUT4. Leto, D & Saltiel, A. R. https://www.nature.com/articles/nrm3351
- https://en.wikipedia.org/wiki/Proinsulin
- Harmonization of immunoassays for biomarkers in diabetes mellitus, Hörber. S https://www.researchgate.net/publication/331307322_Harmonization_of_immunoassays_for_biomarkers_in_diabetes_mellitus
- Evolution of Insulin Delivery Devices: From Syringes, Pens, and Pumps to DIY Artificial Pancreas, Kesavadev, J. et al. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261311/
- JDRF: NICE program https://jdrf.org.uk/knowledge-support/managing-type-1-diabetes/guide-to-type-1-diabetes-technology/insulin-pumps/can-i-get-an-insulin-pump-on-the-nhs/
- Integration of Islet/Beta-Cell Transplants with Host Tissue Using Biomaterial Platform, Clough, D.W. et al. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253249/
What is From Bench to Bedside ?
From Bench To Bedside takes the listener on a journey through the history of diseases, medical discovery, and modern therapeutic development. The field of medicine and science are inextricably intertwined. PhDs are indeed the first "doctors" predating MDs by hundreds of years. As the body of knowledge has grown the specialties have necessarily diverged but are reliant on each other for translation of science into medical treatments. Host Dr. Melanie Matheu (PhD) highlights the stories of scientific and medical collaboration that have brought us the breakthroughs of the past and discusses the ones we will need in the future.