Dr. Jesse Thompson joins Andrew and Tyler from
his ski-town practice, Prime Medical Clinic, in Rossland, BC, where he's built something increasingly rare in medicine: a genuinely well-rounded practice spanning pain management, regenerative medicine, and aesthetics. What makes this conversation particularly valuable is Jesse's perspective on how these disciplines intersect—and his refreshingly honest take on why he doesn't need to hard-sell aesthetic treatments when patients are coming to him for comprehensive care.
The heart of this episode digs into integrative and functional medicine—not the Instagram-influencer version, but the practical reality of catching metabolic problems before they become disease categories. Jesse breaks down how measuring fasting insulin (rather than waiting for the conventional three-month blood sugar check) catches insulin resistance years earlier, and why the shift from "sick care to health care" is both desperately needed and financially complicated. He doesn't shy away from the peptide conversation either, offering a grounded perspective on BPC-157, GLP-1 agonists, and why half the people buying peptides online are wasting their money on contaminated compounds that do nothing—or worse.
The guys also tackle what it's like being a male injector in a female-dominated field (spoiler: having your wife as your practice partner solves a lot of problems), the myth of metformin as a longevity wonder drug, and Jesse's philosophy on work-life balance with three kids under seven and multiple businesses. His answer to the "best bang for your buck" anti-aging question might frustrate anyone looking for a quick fix: resistance training and staying fit your whole life. Sometimes the unsexy answer is the right one. This episode is essential listening for anyone trying to build a practice that's both profitable and principled.
- (00:00) - Welcome to Botox Cowboys
- (00:14) - Introducing Dr. Jesse Thompson
- (01:58) - The Aesthetics Journey
- (09:28) - Integrative Medicine
- (14:48) - Peptides
- (18:34) - Metformin
- (20:18) - The Canadian Healthcare System
- (23:54) - Being a Guy in a Female Dominated Field
- (25:48) - On Balance
What is botox COWBOYS?
A doctor, a cowboy, and a syringe walk into a podcast. This is that podcast.
Welcome to botox COWBOYS, the aesthetics podcast for people who don’t think they’re the type to listen to an aesthetics podcast.
Hosted by Dr. Andrew Dargie — world-class injector with a cowboy’s charm and a scalpel-sharp wit — and Tyler Brooker — his best friend, first patient, and full-time guinea pig — this show cuts through the stigma, the sales talk, and the social media smoke to give you the unfiltered truth about cosmetic medicine.
Whether you’re a provider, a patient, or a skeptical cowboy who thinks “filler” is just what goes in fence posts, you’re welcome here. We’re talking botox, biostimulants, and bad decisions; filler myths, forehead lines, and why men are still weird about all of it.
No gatekeeping. No BS. Just honest, hilarious, and sometimes slightly horrifying stories from the front lines of beauty.
So saddle up. Because looking good shouldn’t feel this funny.