WEBVTT NOTE This file was generated by Descript 00:00:00.909 --> 00:00:04.919 Laurel Damashek: Welcome to GN in Ten, a bite sized podcast brought 00:00:04.919 --> 00:00:08.229 to you by the International Society of Glomerular Disease. 00:00:08.619 --> 00:00:13.399 Our hosts are nephrologists and glomerular disease experts Dr. 00:00:13.419 --> 00:00:17.219 Kenar Jhaveri of Northwell Health and Hofstra University on 00:00:17.219 --> 00:00:19.579 Long Island, New York, and Dr. 00:00:19.599 --> 00:00:23.820 Koyal Jain from the University of North Carolina Chapel Hill. 00:00:25.174 --> 00:00:26.194 Koyal Jain: Hi everyone. 00:00:26.224 --> 00:00:30.544 Welcome to this very special episode in GN in Ten with Kenar Jhaveri and me. 00:00:30.864 --> 00:00:35.484 In this special episode, Kenar and I conducted micro interviews with attendees 00:00:35.489 --> 00:00:39.684 at the ASN Kidney Week and asked them what their favorite glomerular disease was. 00:00:40.044 --> 00:00:46.224 To start off, I am a glomerular expert, but my favorite GN is ANCA vasculitis. 00:00:46.554 --> 00:00:49.704 It is extremely satisfying to help patients who often do 00:00:49.704 --> 00:00:51.234 not get diagnosed for a while. 00:00:51.774 --> 00:00:55.304 Also, the ability to make a difference in patients' disease process and 00:00:55.304 --> 00:00:57.544 quality of life is gratifying. 00:00:57.944 --> 00:01:01.084 Let's see what you all found most interesting in the 00:01:01.084 --> 00:01:02.254 glomerular disease world. 00:01:02.461 --> 00:01:03.346 We have Dr. 00:01:03.356 --> 00:01:07.390 Anna Burgner with us and what's your favorite glomerular disease? 00:01:07.390 --> 00:01:10.270 Anna Burgner: My favorite glomerular disease is preeclampsia because 00:01:10.270 --> 00:01:14.210 it is the most common glomerular disorder in the entire world. 00:01:14.990 --> 00:01:15.817 Koyal Jain: Thank you so much. 00:01:16.317 --> 00:01:18.037 Nasim Wiegley: Hi, my name is Nasim Wiegley. 00:01:18.057 --> 00:01:21.627 I'm an assistant professor at University of California, Davis. 00:01:21.657 --> 00:01:24.267 And I have a glomerular disease clinic at Davis. 00:01:24.757 --> 00:01:28.237 My favorite GD disease is lupus nephritis mainly because of the 00:01:28.237 --> 00:01:33.387 complexity and also the availability of many various options for treatment. 00:01:33.767 --> 00:01:34.827 Joyita Bharati: My name is Joyita. 00:01:34.847 --> 00:01:36.207 I'm a fellow at BMC. 00:01:36.207 --> 00:01:39.037 My favorite glomerular disease is podocytopathy. 00:01:39.113 --> 00:01:40.113 Two main reasons. 00:01:40.113 --> 00:01:42.883 Number one, it's a diversified diagnosis. 00:01:42.883 --> 00:01:44.543 Many etiologies exist. 00:01:44.823 --> 00:01:46.153 However, it's still puzzling. 00:01:46.153 --> 00:01:48.543 The pathogenesis is still not clear. 00:01:48.963 --> 00:01:51.473 And because of point number one, there's a huge prospect 00:01:51.473 --> 00:01:52.923 for research in this subject. 00:01:53.133 --> 00:01:56.178 I hope that soon in the future, therapeutics will directly 00:01:56.178 --> 00:01:59.878 target the podocyte instead of only treating the epiphenomenon. 00:02:00.081 --> 00:02:03.671 Sri Yarlagadda: Sri Yarlagadda from the University of Kansas Medical Center. 00:02:03.819 --> 00:02:08.559 My favorite glomerular disease is ANCA vasculitis because there's 00:02:08.599 --> 00:02:14.153 definite paths for treatment and it's not as vague as the other GN. 00:02:14.983 --> 00:02:16.613 Koyal Jain: Thank you so much Sri, I appreciate it. 00:02:16.849 --> 00:02:18.329 Monica Reynolds: My name is Monica Reynolds. 00:02:18.389 --> 00:02:21.839 I'm from the University of North Carolina and my favorite 00:02:21.839 --> 00:02:24.139 glomerular disease is preeclampsia. 00:02:24.639 --> 00:02:28.169 It's the most common glomerular disease worldwide and affects 00:02:28.179 --> 00:02:30.589 kidney patients in large numbers. 00:02:31.139 --> 00:02:36.459 It also causes increased risk for chronic kidney disease and cardiovascular disease 00:02:36.539 --> 00:02:42.929 after pregnancy and is now being redefined by new endothelial markers that were 00:02:42.929 --> 00:02:45.169 originally discovered by nephrologists. 00:02:45.421 --> 00:02:48.051 Prakash Gudsoorkar: My name is Prakash Gudsoorkar from Cincinnati, 00:02:48.051 --> 00:02:52.401 and my area of clinical interest is onconephrology and oncohypertension. 00:02:52.401 --> 00:02:57.661 Thrombotic microangiopathy pattern, or TMA, is my favorite glomerular disorder. 00:02:57.788 --> 00:03:02.368 TMA is like a medical detective story where every case is a puzzle involving 00:03:02.378 --> 00:03:04.128 the kidneys, blood, and the immune system. 00:03:04.228 --> 00:03:08.178 It requires piecing together clues from clinical presentation, lab results, and 00:03:08.178 --> 00:03:10.178 patient history to save lives and kidneys. 00:03:10.380 --> 00:03:14.500 James Novak: Hi, this is James Novak from Henry Ford Hospital in Detroit, Michigan. 00:03:14.950 --> 00:03:19.400 My favorite glomerular disease is diabetic glomerulopathy because that 00:03:19.400 --> 00:03:23.070 is at least one of the most common glomerular diseases in the United 00:03:23.070 --> 00:03:26.500 States and there are some excellent treatments to attenuate its progression. 00:03:26.960 --> 00:03:27.980 Koyal Jain: Thank you so much. 00:03:28.020 --> 00:03:28.940 I appreciate it. 00:03:28.940 --> 00:03:30.740 Purva Sharma: Purva Sharma from Northwell Nephrology. 00:03:31.110 --> 00:03:33.080 My favorite disease is lupus nephritis. 00:03:33.650 --> 00:03:36.140 I think every single time there's a new presentation, there's a new 00:03:36.140 --> 00:03:38.100 pathology, which makes it so interesting. 00:03:38.570 --> 00:03:42.060 The other thing is that after a large period of negative trials, we suddenly 00:03:42.060 --> 00:03:45.303 have a lot of positive trials in the last five years, which holds a 00:03:45.303 --> 00:03:50.453 very promising future for this young population with a large unmet need. 00:03:50.948 --> 00:03:53.964 So we have a lot to look forward to in lupus, including CAR T, 00:03:54.638 --> 00:03:56.128 which makes it so interesting. 00:03:57.096 --> 00:03:58.636 Gabriela Amador: My name is Gabriela Amador. 00:03:58.966 --> 00:04:01.496 I'm from Hospital General de México in Mexico City. 00:04:02.021 --> 00:04:06.321 My favorite glomerular disease is membranous nephropathy because it has 00:04:06.331 --> 00:04:08.351 followed me since my nephrology training. 00:04:08.941 --> 00:04:12.991 In my public and private practice, I have many patients with this disease, 00:04:13.361 --> 00:04:18.061 and I find it challenging, mostly when we have limited resources for the diagnosis 00:04:18.101 --> 00:04:19.811 and follow up, like in my country. 00:04:20.371 --> 00:04:23.571 It's enthusiastic how the knowledge of the disease has 00:04:23.601 --> 00:04:25.691 grown during the last few years. 00:04:26.396 --> 00:04:28.066 Rose Mary Attieh: My name is Rose Mary Attieh. 00:04:28.086 --> 00:04:31.646 I'm a glomerular disease and onconephrology fellow at Northwell. 00:04:32.216 --> 00:04:38.166 My favorite GN is C3 glomerulopathy and the reason I chose it is because I'm 00:04:38.166 --> 00:04:43.136 so fascinated by its pathophysiology and by all the complexities of the 00:04:43.156 --> 00:04:44.886 alternative complement pathway. 00:04:44.886 --> 00:04:50.186 I'm also very excited about all the new clinical trials that are ongoing and I 00:04:50.186 --> 00:04:54.216 feel like for the first time we may have something more to offer these patients 00:04:54.216 --> 00:04:56.166 and to change the course of their disease. 00:04:57.020 --> 00:04:59.460 Medha Airy: This is Medha Airy with Baylor College of Medicine. 00:05:00.060 --> 00:05:03.750 My favorite GN is lupus nephritis and my passion for this disease 00:05:03.750 --> 00:05:06.920 makes me dedicate my time to Lupus Foundation of America as well. 00:05:07.060 --> 00:05:10.960 I would describe lupus nephritis as an intriguing autoimmune disease that 00:05:10.960 --> 00:05:15.330 can affect kidneys in many different ways and it is a challenge to treat. 00:05:15.363 --> 00:05:20.100 New emerging treatment options recently are definitely revolutionary and 00:05:20.100 --> 00:05:24.420 promising and I'm so excited to be part of this changing landscape for lupus. 00:05:25.100 --> 00:05:28.790 Rushang Parikh: My name is Rushang Parikh, and I am a nephrologist at the 00:05:28.790 --> 00:05:30.860 VA Northport in Long Island, New York. 00:05:31.350 --> 00:05:35.580 And my favorite GN probably has to be ANCA associated vasculitis. 00:05:36.030 --> 00:05:37.440 It's so fun to treat. 00:05:37.490 --> 00:05:39.950 Patients can have rapid recovery. 00:05:40.020 --> 00:05:43.310 And overall, it's a very satisfying disease to treat when caught early. 00:05:43.780 --> 00:05:47.240 And one of the best feelings to have as a physician and as a nephrologist 00:05:47.250 --> 00:05:48.960 is to save somebody's kidneys. 00:05:49.402 --> 00:05:50.172 Koyal Jain: I have Dr. 00:05:50.172 --> 00:05:52.942 Steve Sozio with me from Hopkins here. 00:05:53.082 --> 00:05:54.722 And what's your favorite glomerular disease? 00:05:55.252 --> 00:05:56.392 Steve Sozio: My favorite disease is membranous. 00:05:56.392 --> 00:05:59.072 Membranous continues to evolve in its treatment. 00:05:59.072 --> 00:06:03.272 It's exciting how well rituximab is a effective treatment, especially 00:06:03.272 --> 00:06:05.172 in PLA2R positive membranous. 00:06:05.762 --> 00:06:06.452 Koyal Jain: Thank you so much. 00:06:06.610 --> 00:06:09.670 Duvuru Geetha: My name is Duvuru Geetha and I'm a nephrologist at Johns Hopkins 00:06:09.670 --> 00:06:11.290 University, Baltimore, Maryland. 00:06:11.290 --> 00:06:14.950 I like taking care of complex and challenging diseases, and ANCA associated 00:06:14.950 --> 00:06:22.310 vasculitis is one of them at each stage of the patient's journey at diagnosis, 00:06:22.520 --> 00:06:25.060 during prognostication, and treatment. 00:06:25.304 --> 00:06:26.844 Keisha Gibson: My name is Keisha Gibson. 00:06:26.864 --> 00:06:29.264 I am chief of pediatric nephrology at the University of 00:06:29.294 --> 00:06:30.424 North Carolina at Chapel Hill. 00:06:30.984 --> 00:06:35.614 My favorite glomerular disease is the one that I actually hate the most, which 00:06:35.614 --> 00:06:38.054 is focal segmental glomerulosclerosis. 00:06:38.054 --> 00:06:39.154 Koyal Jain: So why do you hate it? 00:06:39.474 --> 00:06:40.524 And why is it your favorite? 00:06:41.164 --> 00:06:45.564 Keisha Gibson: I hate it because it is a diagnosis based upon histology. 00:06:45.564 --> 00:06:49.004 It doesn't reveal to us initially who it really is. 00:06:49.484 --> 00:06:53.504 What I like about it is the fact that it is the source of, I think, a 00:06:53.504 --> 00:06:56.784 lot of what's exciting right now in nephrology as we're moving more into 00:06:56.784 --> 00:07:00.744 this era of precision medicine and that we're understanding that this disease 00:07:00.754 --> 00:07:05.384 that we give one name is actually probably 50 or 100 different diseases. 00:07:05.724 --> 00:07:11.619 So I hate FSGS, but I'm also very excited by what it's doing for our field and how 00:07:11.619 --> 00:07:13.109 it's helping us to advance what we do. 00:07:13.439 --> 00:07:14.679 Koyal Jain: Thank you so much. 00:07:14.679 --> 00:07:15.459 Javier Neyra: Hello, everybody. 00:07:15.469 --> 00:07:16.419 Javier Neyra. 00:07:16.439 --> 00:07:18.869 I'm from University of Alabama at Birmingham. 00:07:18.879 --> 00:07:24.846 My favorite glomerular disease is IgA nephropathy because of its high prevalence 00:07:24.886 --> 00:07:29.866 worldwide and because there is still fine tuning in the therapy to be done. 00:07:30.566 --> 00:07:30.996 Koyal Jain: Awesome. 00:07:30.996 --> 00:07:31.786 Thank you so much, Javier. 00:07:32.201 --> 00:07:34.841 Faten Aqeel: My name is Faten Aqeel, a Glomerular Diseases 00:07:34.841 --> 00:07:36.201 Fellow at Johns Hopkins. 00:07:36.661 --> 00:07:40.891 My favorite glomerular disease is Anti-Glomerular Basement Membrane Disease. 00:07:41.208 --> 00:07:44.548 I like challenges, and this rare disease can be challenging. 00:07:44.928 --> 00:07:49.908 For example, it can co present with ANCA vasculitis or membranous nephropathy 00:07:49.908 --> 00:07:51.998 and can have an atypical presentation. 00:07:52.508 --> 00:07:56.598 Additionally, it poses multiple therapeutic challenges, particularly 00:07:56.598 --> 00:08:00.138 in dialysis dependent patients and those with refractory disease. 00:08:00.687 --> 00:08:02.267 Paul Hanna: Hi, my name is Paul Hanna. 00:08:02.337 --> 00:08:04.937 I'm with the Medical College of Wisconsin Division of Nephrology. 00:08:05.467 --> 00:08:09.917 My favorite GN is TMA because of how far our understanding 00:08:10.307 --> 00:08:13.557 has gotten into the complement dysfunction and all the different 00:08:13.567 --> 00:08:15.287 therapeutics that we can use for it. 00:08:15.487 --> 00:08:19.357 Vandana Niyyar: Vandana Niyyar from Emory University in Atlanta, Georgia, 00:08:19.357 --> 00:08:24.877 and I'm fascinated by lupus nephritis, the wide variety of pathophysiology 00:08:24.917 --> 00:08:29.827 of immune complex deposition, the varied clinical presentations, and 00:08:29.837 --> 00:08:34.667 the management can be so rewarding if we are able to successfully achieve 00:08:34.927 --> 00:08:39.977 histological or clinical remission and prevent progression to ESKD. 00:08:40.033 --> 00:08:42.093 Koyal Jain: So the next person I've known for a while. 00:08:42.093 --> 00:08:42.593 It's Dr. 00:08:42.653 --> 00:08:45.753 Matt Sparks, and I'm excited about what's his favorite glomerular disease. 00:08:46.403 --> 00:08:48.163 Matt Sparks: Hi everybody, this is Matt Sparks. 00:08:48.233 --> 00:08:50.373 I'm the program director at Duke University. 00:08:50.680 --> 00:08:54.538 By far my favorite glomerular disorder is membranous nephropathy. 00:08:54.938 --> 00:08:55.808 Absolutely love it. 00:08:55.828 --> 00:08:56.268 Koyal Jain: Why? 00:08:56.968 --> 00:09:00.138 Matt Sparks: The very first talk I ever gave as a resident was on membranous 00:09:00.138 --> 00:09:06.158 nephropathy, and I was fascinated by it then, and what caused it, and then 00:09:06.198 --> 00:09:09.948 when they finally figured out the majority of the cases were caused by 00:09:09.948 --> 00:09:14.833 an autoantibody to PLA2R, and now all these other ones are coming out, When I 00:09:14.843 --> 00:09:19.313 have a patient with it I'm excited, I'm thinking about what we can do to treat it. 00:09:19.353 --> 00:09:22.953 And also, like, when you see a patient with it, and they're feeling horrible, 00:09:22.953 --> 00:09:27.443 and they're volume overloaded, and then you treat them, and all of it goes away. 00:09:27.978 --> 00:09:31.998 It is just absolutely amazing and you can't wait to go to clinic to see 00:09:31.998 --> 00:09:35.068 them because they're feeling so good. 00:09:35.188 --> 00:09:37.648 Also, it has some historical perspective. 00:09:37.958 --> 00:09:41.958 There's some thought that actually William Shakespeare had membranous nephropathy. 00:09:41.958 --> 00:09:42.428 Koyal Jain: Really? 00:09:42.918 --> 00:09:43.298 Matt Sparks: Yeah. 00:09:43.298 --> 00:09:44.048 Koyal Jain: That is so cool. 00:09:44.108 --> 00:09:49.508 Matt Sparks: Yeah, unfortunately, the association of why may be syphilis. 00:09:50.638 --> 00:09:53.988 But hey, membranous nephropathy is definitely it for me. 00:09:54.028 --> 00:09:57.718 I love it and I seek out any case I can see. 00:09:58.057 --> 00:09:59.277 Kenar Jhaveri: This is Kenar Jhaveri. 00:09:59.417 --> 00:10:03.947 Thank you for listening to our GN in 10 special podcast on what are 00:10:03.947 --> 00:10:07.167 the most happening GNs for our nephrologists around the world. 00:10:07.957 --> 00:10:11.937 My favorite GN I'll end with is Minimal Change Disease or what we 00:10:11.987 --> 00:10:16.107 would call now Diffuse Protocytopathy because it's a novel discovery of 00:10:16.107 --> 00:10:20.006 antinephrin antibodies and I strongly believe we are on to something. 00:10:20.069 --> 00:10:24.036 So I think a lot more future to come on antinephrin nephropathy and 00:10:24.036 --> 00:10:25.446 that's what we should be calling it. 00:10:25.699 --> 00:10:28.949 So with that, we'll thank everybody and see you all 00:10:29.549 --> 00:10:32.969 . Laurel Damashek: This has been GN in 10 from the International 00:10:32.969 --> 00:10:35.109 Society of Glomerular Disease. 00:10:35.609 --> 00:10:38.959 You can listen and subscribe wherever podcasts are found 00:10:39.379 --> 00:10:41.829 and tweet at us at ISGDtweets. 00:10:42.759 --> 00:10:44.179 Thank you for joining us.