#Ozempic #GLP1 #WeightLoss #Wegovy #Mounjaro
Why do most people regain the weight after stopping Ozempic, Wegovy, Mounjaro or Zepbound? As a board-certified Internal Medicine and Obesity Medicine physician, I walk through the 5 reasons weight comes back: your metabolism, your hunger hormones, stopping the medication, your activity level and not watching the scale. For each one, I go through what the research actually shows, including the Biggest Loser follow-up studies, the STEP and SURMOUNT-4 trials and a 2026 BMJ review of 37 studies. Then I share the 5-step plan that gives you the best odds of keeping the weight off, plus my own story of losing 45 pounds, regaining it and losing it again.
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TIMESTAMPS
0:00 The Biggest Loser study
1:26 Who this video is for
2:08 My own regain story
3:45 Reason 1: Your metabolism slows down
4:53 Reason 2: Hunger hormones stay turned up
6:04 Reason 3: The medication stops
8:23 Free GLP-1 Diet Cookbook
9:01 Reason 4: Activity doesn't stay high enough
11:04 Reason 5: Nobody is watching the scale
12:48 The plan: 5 things that give you the best odds
15:57 The 30-second scorecard
16:45 GLP-1 Masterclass
REFERENCES
1. Fothergill E, et al. Persistent metabolic adaptation 6 years after "The Biggest Loser" competition. Obesity. 2016. https://pubmed.ncbi.nlm.nih.gov/27136388/
2. Sumithran P, et al. Long-term persistence of hormonal adaptations to weight loss. N Engl J Med. 2011. https://pubmed.ncbi.nlm.nih.gov/22029981/
3. Wilding JPH, et al. Weight regain after withdrawal of semaglutide: STEP 1 trial extension. Diabetes Obes Metab. 2022. https://pubmed.ncbi.nlm.nih.gov/35441470/
4. Rubino D, et al. Continued semaglutide vs placebo for weight loss maintenance (STEP 4). JAMA. 2021. https://pubmed.ncbi.nlm.nih.gov/33755728/
5. Aronne LJ, et al. Continued tirzepatide for maintenance of weight reduction (SURMOUNT-4). JAMA. 2024. https://pubmed.ncbi.nlm.nih.gov/38078870/
6. West S, et al. Weight regain after cessation of medication for weight management. BMJ. 2026. https://pubmed.ncbi.nlm.nih.gov/41500720/
7. Kerns JC, et al. Increased physical activity associated with less weight regain six years after "The Biggest Loser." Obesity. 2017. https://pubmed.ncbi.nlm.nih.gov/29086499/
8. Lundgren JR, et al. Healthy weight loss maintenance with exercise, liraglutide, or both combined. N Engl J Med. 2021. https://pubmed.ncbi.nlm.nih.gov/33951361/
9. Wing RR, et al. A self-regulation program for maintenance of weight loss (STOP Regain). N Engl J Med. 2006. https://pubmed.ncbi.nlm.nih.gov/17035649/
10. Wing RR, Phelan S. Long-term weight loss maintenance. Am J Clin Nutr. 2005. https://pubmed.ncbi.nlm.nih.gov/16002825/
11. Jensen MD, et al. 2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults. Circulation. 2014. https://pubmed.ncbi.nlm.nih.gov/24222017/
This video is for education, not medical advice. Talk to your own doctor before making changes to your medication.
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π¨ββοΈ ABOUT DR. MOHAMMED K. PAIKA
Board-Certified in Internal Medicine and Obesity Medicine
Certified Personal Trainer & Nutrition Coach
Helping people understand metabolism, hormones, and sustainable health through evidence-based medicine.
βοΈ MEDICAL & EDUCATIONAL DISCLAIMER: This content is for general educational and informational purposes only and is not medical advice or a substitute for care from your healthcare provider. Viewing this content does not create a doctor-patient relationship. Always consult a qualified healthcare professional before starting, stopping, or changing any medication, diet, exercise, or weight-loss plan. Individual results and risks vary. You assume responsibility for decisions made based on this content.