Plant Based Stem Cells

Show Notes

I am speaking with Christian Drapeau, inventor of a plant-based stem cell product for health and longevity, Stemregen.

Christian is more than a scientist; he’s a stem cell expert and herbalist, pioneering plant-based stem cell enhancers. Yes, plants and stem cells together! His background from McGill University and work at Stemtech International make him a leading voice in stem cell science.

His book, ‘Cracking the Stem Cell Code,’ reveals how our bodies use stem cells for repair, and his latest research shows how aquatic plants can boost stem cell production, like nature’s own fountain of youth.

We’ll explore how Christian’s journey in ancient herbalism led to innovative discoveries in stem cell enhancement and clarify the difference between traditional procedures and products like STEMREGEN.

What is Longevity Optimization with Kayla Barnes-Lentz?

Maximizing Human Health and Performance. We discuss: optimal health, nutrition, high-performance, cognitive excellence, biohacking, longevity and more with top experts around the world. Hosted by Kayla Barnes-Lentz.

This podcast is in partnership with my Clinic, LYV The Wellness Space, Investment Fund, Optimal Health Ventures, and my partner, Bobby George.

KAYLA BARNES-LENTZ: 00:00

Welcome to the longevity optimization podcast, where we discuss longevity, optimal health, nutrition, peak performance, cognitive excellence, and so much more. Christian, it is a pleasure to have you with me today on the podcast.

GUEST 2: 00:15

My pleasure. Thank you.

KAYLA BARNES-LENTZ: 00:17

Absolutely. So today, we're gonna be talking about stem cells, and it's one of my favorite topics. I've done a variety of different stem cells, but you have something really special. So I'm excited for you to just walk us through your background and what you're working on now.

GUEST 2: 00:34

My background originally is brain research. So I was, I studied and then did work at the Montreal Neurological Institute. And then one thing leading to another, I was hired to do research on a specific plant, which was Climate Lake Bluegreen Algae to document how it's working in the body, and that's what led to the discoveries that we have done on stem cells. So I would say from around 2,001, then everything went into into the direction of stem cell research.

KAYLA BARNES-LENTZ: 01:04

Well, real quick, just because I'm very interested by the brain. What has changed in terms of brain knowledge from when you first started to now?

GUEST 2: 01:15

Oh my goodness. Well, the biggest one to begin with and which really is putting me at the center of, or putting us at the center of what we'll be talking about today is that I was told, like, just anybody who has been studying medicine or graduated for, I would say, let's say, 5 years and then before 5 years ago and before, the brain does not regenerate. So the brain does not repair. So that was a dogma that has been there for actually over a century. And now we know that it is not true.

GUEST 2: 01:47

The brain does repair, and it is based on stem cells. So that is one of the big, big thing that we have learned about the brain. I think what we have also learned about the brain is that but I I really stopped working with the brain, gee, more than 25 years ago. But what I can say is that one thing we have learned is that the brain has way more plasticity than what was talked about when I studied in this field of research. So the brain is extremely plastic.

GUEST 2: 02:14

We can transform the brain in various ways by developing different kinds of mental habits, if I could say. These are probably 2 of the main things that I've changed tremendously aside from all the sophistication of science in terms of MRI and and and the way that we can image the brain, EEG biofeedback, all these fields have progressed tremendously. But if I were to name 2 things, plasticity and the fact that the brain can repair.

KAYLA BARNES-LENTZ: 02:40

Yes. Yeah. Absolutely. And I agree with that. So you wrote a book on stem cells in 2013.

KAYLA BARNES-LENTZ: 02:46

Is that right?

GUEST 2: 02:48

The first book was in 2010. Actually, it's the only book. It just had a series of, of revisions, by adding more and more data to the book. So the latest version of that book was published about 3 years ago, but it was published in 2010, Cracking the Stem Cell Code.

KAYLA BARNES-LENTZ: 03:06

That's wonderful. And, like, just for anyone that's not up to speed, what is a stem cell?

GUEST 2: 03:11

A stem cell is the my best way of documenting or describing what is a stem cell is first describe what is not a stem cell. All the cells in your body are specialized cell. They will only do one thing, will never transform, will never multiply. Take a cell of your retina, for example. It responds to light, and that's the only thing it will do.

GUEST 2: 03:32

It will never transform. That's true for every single type of cells in your body except stem cells. So at the other end of that fixed spectrum of, you know, of of a cell being what it is, stem cells is actually nothing. Its identity or its ability, is in its or its its identity is in its ability to transform form into other types of cells. So stem cells traditionally have been known to be precursors to blood cells, red blood cells, platelets, and and and red blood cells, platelets, and white cells.

GUEST 2: 04:04

And, really, what was the big discovery in the early 2000 is that stem cells from the bone marrow can indeed transform into all kinds of blood cells, but can also become cells of virtually any any cell types of the body. And that has been really the big discovery about stem cells.

KAYLA BARNES-LENTZ: 04:22

Amazing. Is the term pluripotent meaning it can turn into any type of stuff?

GUEST 2: 04:28

I mean, there is there's quite a bit. We can dive into this. There's quite a bit of, confusion, if I could say, in the scientific literature because of the evolution of all of our understanding about stem cells. So at first, stem cells were either multipotent, pluripotent, totipotent. And then as the science evolved, these terms still mean something.

GUEST 2: 04:51

Multipotent, it's a stem cell that can become into a few types of cells, pluripotence, many types of cells, totipotence can become everything in the body. And while it was originally believed that stem cells in the human body in the adult or after birth were only multipotent stem cells, stem cells have way more flexibility than what was initially believed. So the human body has stem cells that are definitely pluripotent, and we can probably flirt a little bit with the term almost totipotent.

KAYLA BARNES-LENTZ: 05:24

Amazing. And how many estimated stem cells are we born with, and what happens to those stem cells as we age?

GUEST 2: 05:33

You're born with many. I don't know if I have a number, but you're born with red marrow. All the bones of a newborn are are filled with red marrow, but that red marrow very quickly converts into yellow marrow that does not make stem cells. And by age 30, you've lost almost 90% of your red marrow, which corresponds to a 90% decline in the number of stem cells in circulation. Number of stem cells from a percentage wise of all your cells, meaning that you may have more in numbers when you're an adult, but proportionally per microliter of blood, your amount is extremely is much, much smaller.

GUEST 2: 06:13

So if we keep amount of blood, if you want, the same as a as a as a, as a baseline, you probably have as a newborn, I don't know, a 100 a 100 stem cells per microliter, and then by age 30, maybe 6 to 8, by age 50, maybe 1 stem cell per microliter of blood, just to give you an idea of the of the decline in how many stem cells we have in our blood. And that's your repair system. It's your capacity to repair whenever you have an injury or a problem and your capacity also to keep the health that you have today and keep it for decades to come. It's all based on how many stem cells you have in your bloodstream.

KAYLA BARNES-LENTZ: 06:53

That was gonna be my next question. So how do stem cells work? Are they constantly being released, like, at a slow drip, or is it only when virus or in in some sort of injury occurs that they're released?

GUEST 2: 07:06

They're constantly released from your bone marrow. The best way to see that because it's not something that is easy to quantify the release. We can quantify how many you have in the bone marrow. We can quantify how many you have in the blood, but you cannot quantify if you want the release. So the best way to understand that you release stem cells constantly is that the residence time of the stem cells in the blood will be on average about 1 hour up to maybe 6 hours, but an average of about 1 hour.

GUEST 2: 07:35

So the fact that you have stem cells in your bloodstream means that you release them constantly. So it's a constant flow releasing stem cells, in your bloodstream, and it it it sort of varies, highest around 5 AM. Sorry. High yeah. Highest around 5 AM, lowest around 5 PM.

GUEST 2: 07:53

So there's a circadian cycle of these stem cells but release them all the time. And they're playing a role both in tissue repair but also in maintenance, like replacing the cells that are being lost. Was that your question?

KAYLA BARNES-LENTZ: 08:05

Yes. That was. And then more are more released. Let's just say you have a surgery or in a car accident or become ill. Is that when you would expect to see a release of more?

GUEST 2: 08:16

Absolutely. So they are your repair system. What I mean by this is that let's say you cut your finger, and and I will make the parallel heal here with the immune system because I think that that is the key message for people to understand is that just like you have an immune system, like, if you have a cold, the first thing that you will do is to boost your immune system. You won't think twice about it. You need to understand just like you have an immune system, you have a repair system.

GUEST 2: 08:44

So in the way that it works, let's say you cut your finger and then you have an infection. So the first thing that will happen is that macrophages, immune cells locally, will detect the infection, will send a signal to the stem cells sorry, to the immune cells from your lymph node, and then you will release immune cells in your blood circulation. They will go everywhere in the body, but they will specifically migrate in the area where you have this infection. They will migrate beside the bacteria and kill the bacteria. That's your immune system.

GUEST 2: 09:15

But at the same time, the injured tissue will release compounds that have been very well documented in the scientific literature. These compounds will go to the bone marrow, trigger the release of stem cells from the bone marrow. A finger on your a cut on your finger may not really do the job, but let's say a broken bone, severe wounds, a surgery, heart attack, stroke, whatever. Something that is a significant injury, it will trigger the release of stem cells from the bone marrow to the point that within 3 to 5 days, you will have an increase of maybe 3 to 9 fold in the increase in the number of stem cells in circulation. As they go everywhere, the area where the where you have the injury will locally release local signals that will tell stem cells when they when they circulate into the fine capillaries of the affected tissue, it will tell them to migrate out of the blood into that tissue.

GUEST 2: 10:08

And when they get in contact with cellular debris of that tissue, they will multiplies. 1 stem cell will become something like, let's say, 5,000 tissue cells, and they transform into cells of that tissue, literally repairing that tissue. So stem cells, that's how they work. They are your repair system. Anytime you've had an injury since you're a child, since you're born, every single time, stem cells is really what did the job to repair.

KAYLA BARNES-LENTZ: 10:34

Wow. I love that visual. Thank you for walking us through it. Hi. We're taking a short break from the podcast to discuss a new community that I have launched.

KAYLA BARNES-LENTZ: 10:43

I wanna preface this by saying that I will continue to post content on my social platforms and conduct interviews on this podcast that are both free and applicable to both sexes. But as a woman, I have unique insights and perspectives on female health. I recently launched my first ever paid offering, and this is a female only health optimization and longevity community. If you are a male, you can skip this portion of the podcast or you can forward this information to a female that you think would be interested. I set out to create the most valuable longevity optimization community for women.

KAYLA BARNES-LENTZ: 11:19

I have spent over the last decade dedicating my life to human optimization and have dived deep into the female specific optimization and protocols. This is a place I want you to learn everything you need to know about optimizing your health, longevity, and mindset. I made this a community only for women because I wanted us to be able to be open, which I didn't feel could be done in the comments section of my Instagram. I also love the idea of women sharing protocols of what's working best, and everybody within the community can offer valuable insights to each other and support. Members get weekly and biweekly ask me anythings.

KAYLA BARNES-LENTZ: 11:58

Exclusive content and protocols like articles, videos, and a whole host of courses, and you'll receive up to date female longevity is science. You'll also get community and connection with like minded women, access to virtual and in person events with me, and your membership will help support female human studies in the very near future. You can learn more about this membership on my website, kaylavarnes.com. Okay. So now that we know how stem cells work, let's talk about let's talk about some differences in stem cells, and then please explain your your product because, I mean, I've been hearing about your product, just so you know, all over the longevity community.

KAYLA BARNES-LENTZ: 12:40

So I'm very excited. Stem cells that I have had in the past are more I've had v cells. I've had, exosomes. There's all sorts of stem cell products out there. Do you wanna just give a quick overview how your product is different, obviously, and what these other these are more treatments, but what those may be able to impact?

GUEST 2: 13:03

It's a it we we could really dive a lot on that question and go and go deep. I'll try to keep it sort of simple and and broad as a response. We have diff we have access to different types of stem cells, umbilical cord stem cells, v cells, bone marrow stem cells, fat derived stem cells, and in rare applications, not because it's difficult or rare by itself, but not a lot of people do it in this country, air follicle stem cells, and dental pulp stem cell. These are, like, different types of human derived stem cells that can be utilized. They all have their pro and their cons.

GUEST 2: 13:41

Umbilical cord stem cells are young, so they're probably the strongest stem cells if you want. But they they come with potential side effects or negatives that are still question marks for a large to a large extent. Like, could we have foreign tissue into that sample of stem cells that you could that your immune system can react to, or could you incorporate stem cells that have a different genome than yours? Of course, they have a different genome, but some sort of gene genetic defect that could suddenly develop in you. Some evidence were published to that about a month ago.

GUEST 2: 14:16

But so far, generally speaking, it's not a risk that has really materialized. Fat derived stem cells, they are not aging as fast as your bone marrow stem cells, so they're considered, like, on the young side. Probably not as potent as as, bone marrow derived stem cells, but but younger. So it's kind of a toss here which one are are better. Bone marrow stem cells are painful to go and get from the bone marrow.

GUEST 2: 14:41

You need to have a bone marrow respiration. Some people tell you it's a breeze, other people told you it was really painful. So so it's still done, but it's not extremely common. And the v cells, they are in your bone marrow. They are in muscles.

GUEST 2: 14:55

They are in different parts of your body, but we collect them from the bloodstream. And they are either in a quiescent, say, dormant state or activated state. So there are techniques to activate these stem cells. We take a blood sample, activate these stem cells, put them back into your bloodstream. They are in the human body, in the adult body.

GUEST 2: 15:13

They are those cells that are almost totipotent, the v cells. So sorry. They're very, very potent. What we do to make it into some sort of a, I wouldn't say a comparison, but, like, in in in contrast with these different treatments, All these treatments end up putting more stem cells in circulation, vastly more stem cells in circulation into a one time event, an injection. Then you get this boldness of stem cells into your bloodstream with an estimated about 15% survival of these stem cells.

GUEST 2: 15:49

And it's a one time event. What we do is that we take plant extract that when you consume them, we have documented that they trigger the release of your own stem cells. You take, for example, 2 capsules of stem region, you will have about 10 around 10, 12,000,000 additional stem cells in circulation within 2, 3 hours. It's less than a 100,000,000, But if you do this every day or several times a day and you do this over long periods of time, the advantages that it gives is that you can do it for as long as you want want at a price or a cost that is obviously much less. And it is physiological, meaning we don't put into your bloodstream more stem cells than what your own repair system would call for if you had any kind of injury.

GUEST 2: 16:35

So it's very physiological, So these stem cells can incorporate everywhere in your body and slowly participate in this process of tissue repair. That's sort of a what was that a a good overview of what is available?

KAYLA BARNES-LENTZ: 16:48

Yeah. That was a great overview. So talking about stem regen specifically, how is this essentially plant invoking or releasing more stem cells in our body? How is that working?

GUEST 2: 17:04

Again, we can go so deep in the in the chemistry, but generally speaking, think of in in the whole world of stem cell mobilization, the way that a stem cell gets released in the bloodstream is all connected to the interaction between a molecule called SDF 1 and a receptor for SDF 1 at the surface of stem cells. When these two connects, it makes the stem cell express a desion molecule and the stem cell cling to the bone marrow environment. Anything that interferes with that connection will lead to the release of stem cells from the bone marrow. When you have an injury, the signal that goes to the bone marrow will make your bone marrow secrete an enzymes that will digest SDF one. Without SDF one, you no longer have the connection with the receptor.

GUEST 2: 17:51

The stem cell gets detached from from the bone marrow. So anything that can interfere. So we have in one of the, plan that we use, the blue green algae, we have a blocker of l selectin that reduces the expression of the receptor. So yes, f you have SDF 1, but the cells are fewer of these have fewer of these receptors, so their capacity to adhere to the bone marrow environment is reduced. So they detach from the bone marrow.

GUEST 2: 18:18

They get into into the bloodstream. Other plants will almost play a a role in the body just like like, for example, fasting mimicking compounds. Plants that you could plant extract, that you consume that will initiate in your cells a response comparable to fasting, which is autophagy. So we also have the same thing. We have plants that are triggering in the body a response similar to what is an injury without being an injury.

GUEST 2: 18:45

It's not coming from a toxicity. It's not coming from a microinjuries to the body. None of that. It's just basically making your immune cells secreting some of the compounds that are calling for for stem cells. So in various ways, these different plant extracts simply work to, to stimulate or support the release of stem cells from the bone marrow.

GUEST 2: 19:06

So we count the number of stem cells before and after, and we can tell you how many more stem cells are in circulation.

KAYLA BARNES-LENTZ: 19:14

And what are the plans that are doing this?

GUEST 2: 19:17

We have studied probably about, like, what, 20 plant or so over the years. And right now, we have we have focused in StemRigen on the top five that are giving us or have given us the greatest response. So we have Climate Lake blue green algae. So we have an extract of that, that blue green algae that is giving an a release of about one gram of it about an increase of 20% in the number of circulating stem cells. We have aloe macrocollata from Madagascar.

GUEST 2: 19:45

This is almost doubling the number of stem cells in circulation. We have seabuck thornberry extract from the Tibetan plateau increasing by about 35% the number of stem cells in circulation. We have notogensin, extract. This is work that has been done by another group, but they reported in mice an increase of about a doubling in the number of stem cells in circulation. And we have a polysaccharide from brown seaweed called fucoidan, putting about an increase of about, what, 25% in the number of circulating stem cells.

GUEST 2: 20:16

These are the top plans that we have worked with over the years.

KAYLA BARNES-LENTZ: 20:20

And you can't consume these ingredients just as food. Right? Because you'd have to eat way too many?

GUEST 2: 20:27

Some of them, you would have to eat too many. Others are just not really available, like the the like the aloe macroclata from Madagascar. This is not a species of aloe that is easily available, so would really only harvest it in Madagascar. Seabuck tonberry, you could. You would just have to eat quite a bit of seabuck tonberry every day.

GUEST 2: 20:48

Ficoidan, seaweed, more difficult. This one, you would have to eat so much ficoidan. I mean, sorry, so much fucus. It probably it probably be, you probably get too much iodine to begin with by eating the plant itself, and you'd probably be sick on the amount of of fucus that we'd have to eat. So, yes, to an extent, some of them are just too concentrated.

GUEST 2: 21:09

Like, you will have to eat too much to get the effect.

KAYLA BARNES-LENTZ: 21:12

Yeah. That makes a lot of sense. And what sort of testing are you doing to confirm the increase in additional stem cells?

GUEST 2: 21:19

So the test that we do is that people come in the morning. In the studies, the participants in the studies participants in the studies come in the morning about 8 o'clock in the morning. They rest for about an hour. Then we take a blood sample, then we give them placebo or the test compound the the testing reading that we wanna test. And then we take another blood sample an hour, 2, and 3 hours after.

GUEST 2: 21:41

Then they come 1 week later, we ask them to have exactly the same diet the day before, try to have the same evening, to have the same sleep, try to keep everything as the same as possible. And then we do exactly the same thing giving them either the placebo or the plant extract, whichever they didn't get on the first time. And that allows us to to determine on the placebo what is their normal circadian cycle. And then from that, we basically take the response that we have with the plant and subtract their circadian cycle. So we really see how many stem cells are above their normal number of stem cells in circulation.

GUEST 2: 22:19

And to measure these stem cells, we use flow cytometry. So flow cytometry is a machine, a device that will line up the cells 1 by 1, one behind the other in a very, very small tube, and the cell will pass in front of a laser, that is going to with a photo sensor at the other end, and it's going to give you the size of the cell, its intrinsic luminosity, then we can use different antibodies for marker of stem cells, that also allow us to recognize which cell that is passing in in front of that laser is a stem cell, and then we can count stem cells. It's it's a classical machine and technology to count stem cells.

KAYLA BARNES-LENTZ: 22:57

Very interesting. Would this lead to earlier stem cell exhaustion, though, for releasing more stem cells all the time?

GUEST 2: 23:06

You you won't. Let's spend just a moment here on that term stem cell exhaustion because it's one of the so called hallmark of of aging. But I think that it's misunderstood, not misunderstood by those who necessarily expressed it, but misunderstood in terms of what it means for the general population reading that term and probably for some scientists as well. There is stem cells in the bone marrow, and there's stem cells in your tissues. Every single tissue and organ of the body has its own stem cells.

GUEST 2: 23:37

Before discovering what we know today about stem cells, we already knew that some tissues had a type of cell that was regenerative and was able to multiply more than other type of cells. In muscle, they were called satellite cells. In the liver, they were called oval cells. They are essentially stem cells of that tissue. Now we know every single tissue of the body has the exact same cells.

GUEST 2: 24:02

Now we simply call them cardiac stem cells, brain stem cells, pancreatic stem cells, and so on. But every tissue has its own stem cells. If a tissue has an ongoing insult or degenerative is going through a degenerative problem, the the cells are lost more rapidly than usual, and the stem cell of that tissue are trying to repair that tissue. And after a while, that tissue layer of stem cells is exhausted. That is stem cell exhaustion.

GUEST 2: 24:32

So if that's it's and the best example to understand, take your digestive system with colitis, Crohn's, any of those kinds of problems. You got an injury, an inflammation process. You get degenerative. Something degenerative is happening, and the local layer of stem cells is trying to repair that area of the gut. Until it is exhausted and at that point, it can't repair, you have the experience of the acute phase of colitis.

GUEST 2: 24:58

If we can release stem cells from the bone marrow, they go and they replenish this exhausted layer of stem cells in the gut, then you can help the gut repair on its own, and then the problem goes away. You didn't resolve the the cause of the problem, but you gave back that area of your body the ability to repair and regenerate. So that's stem cell exhaustion in the tissues. In the bone marrow, what you have is stem cell conversion. It's the normal, or I should say natural, conversion of red marrow into yellow marrow.

GUEST 2: 25:30

So far, as far as I know, nothing is known to slow down this this, conversion. Quite frankly, it's a field of research that I'm just starting to to touch here because it would be, I think, if we discover a way to slow down the conversion of bone marrow in a way that is healthy for the bone marrow, it would probably be the single biggest longevity, hack or strategy that we could have. But so far, we cannot so this is the conversion. So it's not really exhaustion. It's normal conversion of the bone marrow.

GUEST 2: 26:02

So until the bone marrow is exhausted with age and then you run out of stem cells to repair. Quite frankly, people pass or die before they actually completely, are exhausted from stem cells. Now the red marrow that you're left with at any age in your lifetime, that red marrow continues to release stem cells at the same rate. So when you get that red marrow release more stem cells, you don't exhaust that red marrow. These stem cells bay basically get back to where they were within minutes.

GUEST 2: 26:33

Like, there's no you don't affect your red marrow by releasing more stem cells. Does that give you

KAYLA BARNES-LENTZ: 26:39

Yeah. So, I mean, basically, the stem cells can be exhausted at a certain area, but they're not necessarily being exhausted as a whole within the body.

GUEST 2: 26:50

Correct. You will get exhaustion in tissue. You can you can compensate or alleviate that exhaustion by releasing more stem cells from your bone marrow. The fact that the bone marrow will continue to continue to decline, that is something that is natural. It's a fact.

GUEST 2: 27:06

It is the one of the main cause of aging. But so far, there's nothing known to change that rate of conversion.

KAYLA BARNES-LENTZ: 27:14

Wow. That seems like an area we need to work on.

GUEST 2: 27:17

I think so.

KAYLA BARNES-LENTZ: 27:20

Okay. Good. Well, that's great to know that we won't be exhausting our stem cells faster. So what obviously, I mean, it sounds like this should be a part of anyone's, let's say, longevity routine, but at what age would you recommend starting a supplement like yours?

GUEST 2: 27:39

Let me let me go back to that conversion of red marrow into yellow marrow. By age 30, you have lost about 90% of that red marrow. We what what stem cell research has revealed, something that is that it I wouldn't say as an idea or a concept. It's new. But it's new in our understanding of it and having data to support that concept, which is the fact that the entire body is constantly in a process of tissue turnover.

GUEST 2: 28:07

We experience aging as being born, I mature, I reach peak health at, let's say, 25 years of age, and then my health slowly start to decline. And we experience that slow decline. So it's almost like a slow fading, but it's not what is happening at the cellular level or at the tissue level. At the tissue level, you lose cells every day, and they are replaced every day by stem cells. That starts from the day you are born.

GUEST 2: 28:36

Constant turnover. And that turnover rate changes is different from various tissues and organ. You have a new lining of the intestine every 5 days, a new skin every month, a new liver every 2, 3 years, half a new heart every 25 years. So at the age that we have, I have a few years a few years ahead of you, but, like, you don't have in your body any any cells in your pancreas that you're born with. It has been a complete turnover several times.

GUEST 2: 29:02

So when you think of it this way, that means you constantly lose cells, you constantly need stem cells to replace the cells that are being lost. But if by age 30, you've lost 90% of that renewal power, that means there's a time in your life when you don't have enough stem cells to offset this constant cellular loss, and you then start to, to have a cumulative deficit that is going to take place either everywhere in the body or in one place that is your weak spot in your body. And if you think about it, thinking about your genetics, your past injuries, your lifestyle, your exposure to environmental toxins, whatever, many factors, you probably know what is the part of your body that is the weak part in your in your life. So that's where it's going to accumulate first. So, so everything is caused by a lack of stem cells in circulation.

GUEST 2: 29:57

I published that view about 10 years ago in the scientific literature, and I was suggesting that there was one way to test for this. Let's go and count the number of stem cells of people who have developed various types of age related diseases, and we should find that they have fewer stem cells when compared to healthy people of the same age. Meaning that it's the it's the fact that they have fewer stem cells that they can maintain their health so that cumulates into a loss of health as they age. So now about 50 studies have been published, and if you look at atherosclerosis, high blood pressure, heart disease, erectile dysfunction, liver failure, kidney failure, COPD, emphysema, Parkinson, Alzheimer's, lupus, arthritis, and the list keeps growing. And everybody on average, statistically speaking, people with these problems have 50% or less than the number of stem cells that we find in a healthy person.

GUEST 2: 30:50

So if you come back to your question, when should we start to take this product, most people will think about taking it when they have an injury. When they really start to develop a problem that they want to resolve, that's when they start to really do something from their health. In the world of of longevity, when we understand that the problem that we will experience in 20 years from now have already started by this deficit in stem cells, then the idea is just to put more stem cells in circulation every day to boost the body's natural ability to maintain its health and then and then do this every day or do it, let's say, let's say do it for a month every change of season. Stem Regen is stronger than other product that I had in the past. So if you release 10,000,000 stem cells with 2 capsules every day for a month, that's 300,000,000 of your own stem cells.

GUEST 2: 31:39

That's significant number. So you may be able to just do this, let's say, for a month every 2, 3 months.

KAYLA BARNES-LENTZ: 31:45

Oh, that's interesting. So, like, cycling.

GUEST 2: 31:49

But what's that

KAYLA BARNES-LENTZ: 31:50

can you also just stay on it? Because I just wanna stay on it forever.

GUEST 2: 31:53

That's what I did. I've I've been on these products for 20 years, because my concept was that you have a decline that accumulates a little bit every day. So my thought was upset offset it a little bit every day. So I've done this always, but I'm I'm also thinking there's a cost. So if somebody wants to say, I I what would be the what can I do to bring benefits to the body without necessarily being the optimal?

GUEST 2: 32:20

Then I would say, well, maybe do a month and do this at change of seasons or several times in the year. But by all means, if you wanna stay on it, that that will be the optimal way of doing it.

KAYLA BARNES-LENTZ: 32:31

Absolutely. What about any differences between sexes? So males and females, would there be a better time during the cycle to potentially take these? Or I'm and I'm so I wanna start a family soon. I'm thinking post post pregnancy.

KAYLA BARNES-LENTZ: 32:48

When would that be a great time to take these?

GUEST 2: 32:51

Yes. If you start before pregnancy so you don't bring something new during pregnancy, then we have had a lot of stories of people who got great benefits with releasing stem cells. I mean, we're starting a stem cell right now sorry, a stem cell, a study, in Turkey out of, of observations that were made by doctors in Turkey, working in a fertility clinic and seeing patients essentially really being able to conceive after being for a few months on stem region. I won't make any claim right now, but it is something that we have seen to the point of funding a study, in that area. So pre, getting pregnant, and definitely post getting pregnant.

KAYLA BARNES-LENTZ: 33:33

Yeah. Absolutely. Because they say it takes 2 years to essentially, you know, re you know, get your body to where it was before the baby. So I definitely want to try to, shorten that time frame.

GUEST 2: 33:48

We have, have you ever heard of catarify?

KAYLA BARNES-LENTZ: 33:51

I have not.

GUEST 2: 33:53

Catarify, I mean, it's beside the topic, but we're talking about pregnancy. Catrafi is a bark that comes from Madagascar. So when I was traveling in Madagascar, healers presented me with this product. So it's a bark. They peel the bark of the tree.

GUEST 2: 34:06

They roll that into a ball, and they use it in Madagascar. Right after pregnancy. You boil this ball of bark, in, obviously, in hot water, for something like, what, 20, 30 minutes. And then after that, you pour that into a tub, and then you wash yourself with that water. And apparently, it has absolutely phenomenal benefits to just tightening all the tissues after delivery.

GUEST 2: 34:30

I have I have never experienced it, with anybody close to me, but I have some of those. I'll send you I'll send you one when you're pregnant. Let me know. I have some with me.

KAYLA BARNES-LENTZ: 34:40

Oh my gosh. I would love that. Thank you. Yeah. I'm excited to see I wonder if you could even follow because what I I feel like we don't have a lot of data on pregnant women.

KAYLA BARNES-LENTZ: 34:51

So what I'm gonna do I'm not gonna do this for all my pregnancies, but the first one, I'm gonna get labs drawn every 2 weeks and look at a huge range of biomarkers and see what's actually happening. But I wonder what happens to the stem cell production or release during the course of pregnancy? I know we're just speculating here. But

GUEST 2: 35:14

It is speculation. We obviously, we've never done any quantification of stem cells on a pregnant woman just because any studies that we do, one of the exclusion criteria is being pregnant. K. Just to remove any of those variables that that a pregnancy could include. So we've never tested a pregnant, pregnant woman in terms of number of stem cells.

GUEST 2: 35:36

I really don't know. It is very interesting that there's a lot of stem cells in the amniotic fluid. So kids, some of these stem cells get back into blood circulation of of the mother. I would I mean, it would be it would be surprising if they did not. So it's it's a very interesting area of, of, of, physiology of the human body that I don't think has been really studied.

GUEST 2: 36:01

It would be it would be interesting.

KAYLA BARNES-LENTZ: 36:03

Yeah. Well, maybe we will collaborate on that because I just find it I find it to be just crazy that we don't have more data on pregnant women. I mean so I'm gonna look to get some of that information. But, yeah, I'm not I'm I'm super excited about your product, and I'm so excited we'll get to connect to the Biohacking Conference, which is coming up. So 2 it's 2 caps per day.

KAYLA BARNES-LENTZ: 36:28

I mean, start as early as you can, essentially. Stay on it for as long as you can. We're we were also discussing, should something happen, you can also up the dosage, you know, for a short period of time, right, if you have an injury or a surgery or something of that nature.

GUEST 2: 36:45

Yep. Think of it as your immune system. You wanna support your immune system all the time, but if you get a cold or you get anything, then you boost your immune system for a while. When the problem is over, then you go back to just maintenance. It's roughly is the same thing.

GUEST 2: 37:00

With the difference here that there's a real consequence of not having stem cells in circulation is that you develop problem as you age. So I would say maintenance is 2 capsules, 1 serving. We have put in 2 capsules the amount of these different extracts, that we did study in those various studies. So that's what we put in 2 capsules. So you take 2 capsules.

GUEST 2: 37:22

You will increase the number of stem cells in circulation by, I see an average, but in reality, it's a minimum of about 10,000,000 additional stem cells in circulation, and then you do that as a maintenance. If something happens, you go to the gym, you work out, like, super hard, add another 2 after your your, your gym, your your workout. And if you really, did something quite significant in your workout, then take another 2 before going to bed, and you will have a very different experience of soreness the day after if you really boost that repair overnight. We've seen it, I don't know how many times, with different people. And, so that that's what I would say.

GUEST 2: 38:02

And if there's any significant problem that show up, or that you wanna deal with, what we have done in our studies is that we always jump start individuals. Two capsules, 3 times a day for maybe a month or a month or 2. And then after that, we can phase out. At whatever age that you have, you just need to understand you have never really boosted the release of your own stem cells. So to see what your body can do with more stem cells, we condense that in, let's say, 1 month.

GUEST 2: 38:31

And after that, you go down. And if you experience that you were better when you were doing more, then you can go back to take more for maybe a a week or 2. There's a point where you'll realize you don't need to take it 3 times a day. You're now back to maintenance. You've really done the amount of repair that your body was was needing.

KAYLA BARNES-LENTZ: 38:49

I'm excited because it's it's very difficult. Getting access to, let's say, stem cell medicine is extremely costly and difficult, can be painful in some cases, and is is really not allowed in most areas. And even where it is allowed, still very difficult to get to. So I'm excited that this can be a way to incorporate maybe into more of, like, a mainstream medicine, in a way to access stem cells, with just a couple supplements.

GUEST 2: 39:17

Yeah. Well, I I cannot, today, with the data that we have, really make a straight comparison to tell you that can replace stem cell injection. What I can say is that we are doing a study right now in Madrid and Florida on, congestive heart failure, so people with stable chronic congestive heart failure. And we have one group on stem regen, one group on adipose derived stem cell injection, and one group with both, a combination of both. And what we see in that study, it's ongoing.

GUEST 2: 39:47

We just have the preliminary data. But what we see is what we had seen historically and what we were expecting, which is stem region already brings really good improvement in heart function. After 6 months, all the patients, in that group have normal cardiac function. Wow. You get similar results with stem stem cell injection and much better by combining both.

KAYLA BARNES-LENTZ: 40:09

Wow.

GUEST 2: 40:11

So I I cannot right now, compare stem cell injection with what we're doing in StemRegen. We don't have the data, and I don't want to really claim that we have a dietary supplement that can do something similar to a treatment. But we have started a study. It's done in Madrid and Florida. It's a it's a multicenter study.

GUEST 2: 40:30

And the aim of this was to document both the effect of StemREGEN, how it compares to stem cell injection, but more importantly, how we can combine these 2 and how they work synergistically because that's what we've seen over the years. So we targeted, congestive heart failure because we had seen a lot of benefits in that area in the past. So we have so far in that study, it's ongoing, but with 10 patients. So stem region after 6 months, they all have normal cardiac function. We get similar results a little bit better with stem cell injection and much better by combining both.

GUEST 2: 41:05

So as we move forward, the idea is just to simply understand that your own stem cells have enormous capability for repair in your own body. The problem is just that as you age, you don't have enough in stem cell in in the you don't have enough stem cells in circulation. So you are not you don't have the capacity to tap into your body's ability to repair. So all we do is that we allow your body to release more stem cells and just tap into its innate ability to repair. And so far, what we have seen is is pretty impressive.

KAYLA BARNES-LENTZ: 41:38

Well, yeah. Absolutely. I would agree. It sounds very impressive. I can't wait to see, you know, the future studies.

KAYLA BARNES-LENTZ: 41:46

So please feel free to send them over. And yeah, I've been loving your product. We're gonna include a discount code for 15% off in the show notes. But, yeah, I really appreciate your time, and I can't wait to meet you in person here soon.

GUEST 2: 42:00

Same thing here.

KAYLA BARNES-LENTZ: 42:01

Alright. Well, thank you for joining me today.

GUEST 2: 42:04

Thank you.