What if the supplements you are taking to improve your health are actually working against the chemistry of your body?
In this episode of Holistic Dynasty, master herbalist and independent biochemistry and nutrition researcher Bryce Hanna joins us for a deep dive into supplementation, methylation, mental health, nutrient deficiencies, and the complicated biochemistry behind why the same supplement can affect two people very differently.
Rather than looking at vitamins and minerals as isolated solutions, Bryce explains why nutrients work together—and why blindly adding supplements without understanding their cofactors, interactions, and downstream effects may create entirely new problems.
We explore methylation, MTHFR, B vitamins, magnesium, iron, thiamine, mineral balance, and the relationship between nutritional biochemistry and psychiatric health. We also discuss why more supplementation is not always better and why sometimes the smartest intervention may be removing something rather than adding another pill.
In this conversation, we explore:
Why more supplements do not necessarily mean better health
How nutrients interact with one another inside the body
Why taking a nutrient in isolation can sometimes backfire
What methylation actually is and why it matters
The relationship between MTHFR, methylation, mood, and mental health
Why methylated B vitamins may not be right for everyone
How magnesium, thiamine, potassium, sodium, and other foundational nutrients work together
Why iron supplementation requires a much bigger conversation about cofactors
How nutritional deficiencies and imbalances may influence psychiatric symptoms
Why individual biology matters when choosing supplements
How food, minerals, sunlight, lifestyle, and supplementation fit together
Why the supplement industry can encourage people to keep adding products without understanding the underlying physiology
How to think more critically before starting your next supplement
Bryce Hanna is a master herbalist, independent biochemistry and nutrition researcher, and consultant whose work focuses on foundational nutrition, herbalism, human physiology, and the biochemical relationships between nutrients.
Through Multiflora Herbs, his research, consultations, articles, and educational content, Bryce encourages people to understand why something works rather than simply following another supplement protocol.
This conversation is not about claiming supplements are bad.
It is about recognizing that human biochemistry is complicated—and that taking the right nutrient, in the wrong form, dose, combination, or context may produce a very different result than you expected.
The goal is not to take more.
The goal is to understand what your body actually needs.
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Disclaimer: This conversation is for educational and informational purposes only and is not intended as medical advice, diagnosis, or treatment. Always speak with a qualified healthcare professional before making significant changes to medications, supplements, diet, or treatment.
Thanks for tuning in!