Radically Genuine Podcast with Dr. Roger McFillin

In 2011, a paper was published in Pharmacogenomics and Personalized Medicine examining the relationship of antidepressants and akathisia side effects in those with genetic mutations in the metabolizing genes of the CYP450 family. In the study, eight of the subjects had committed homicide and many more became extremely violent while on antidepressants.
On today’s podcast we welcome one of the co-authors, Christopher Crotty, and subject, David Carmichael, to share their stories.

Show Notes

In 2011, a paper was published in Pharmacogenomics and Personalized Medicine examining the relationship of antidepressants and akathisia side effects in those with genetic mutations in the metabolizing genes of the CYP450 family. In the study, eight of the subjects had committed homicide and many more became extremely violent while on antidepressants. 

On today’s podcast we welcome one of the co-authors, Christopher Crotty, and subject, David Carmichael, to share their stories.

Twitter: Roger K. McFillin, Psy.D., ABPP
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If you are in a crisis or think you have an emergency, call your doctor or 911. If you're considering suicide, call 1-800-273-TALK to speak with a skilled trained counselor.

ADDITIONAL RESOURCES
  1. Lucire, & Crotty, C. (2011). Antidepressant-induced akathisia-related homicides associated with diminishing mutations in metabolizing genes of the CYP450 family. Pharmacogenomics and Personalized Medicine, 65. https://doi.org/10.2147/pgpm.s17445 
16:00 Zhou, Y., Ingelman-Sundberg, M., & Lauschke, V. (2017). Worldwide Distribution of Cytochrome P450 Alleles: A Meta-analysis of Population-scale Sequencing Projects. Clinical Pharmacology & Therapeutics, 102(4), 688–700. https://doi.org/10.1002/cpt.690
30:00 - Know Your Drugs
39:30 - David Carmichael v. GlaxoSmithKline Inc.
40:00 - Carmichael, D. Calm, organized, homicidal behaviour – my connection to school shooters. Mad In America.
46:15 - RxISK Prescription Drug Side Effects

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Creators & Guests

Host
Dr. Roger McFillin
Dr. Roger McFillin is a Clinical Psychologist, Board Certified in Behavioral and Cognitive Psychology. He is the founder of the Conscious Clinician Collective and Executive Director at the Center for Integrated Behavioral Health.
Host
Kel Wetherhold
Teacher | PAGE Educator of the Year | CIBH Education Consultant | PBSDigitalInnovator | KTI2016 | Apple Distinguished Educator 2017 | Radically Genuine Podcast
Host
Sean McFillin
Radically Genuine Podcast / Advertising Executive / Marketing Manager / etc.
CP
Guest
Christopher Crotty, PhD
Medical Writer | Health Economics and Outcomes Research (HEOR) | Market Access | Digital Health | Clinical Decision Support | CYP450 Pharmacogenetics | Healthcare Professional Training
DC
Guest
David Carmichael
Creator of Know Your Drugs global awareness campaign.

What is Radically Genuine Podcast with Dr. Roger McFillin?

The Radically Genuine Podcast cuts through the noise of conventional mental health advice, offering an unfiltered exploration of what it truly takes to overcome life’s challenges. Dr. McFillin doesn’t shy away from controversial topics, tackling head-on the failings of the mental health industry and exposing the often-ignored realities of resilience.
Each episode features raw, honest conversations with survivors, experts, and freethinkers who challenge the status quo. From dismantling harmful psychiatric practices to uncovering ancient wisdom for modern well-being, this podcast goes where others fear to tread.
It’s more than just talk – it’s a revolution in how we approach mental health and personal growth.