ATS Assemblies & Sections

April 21, 2026

A Podcast on Tirzepatide SURMOUNT-OSA trial and cardiometabolic subanalysis.

A portion of the ATS SRN 360 high impact articles from the past year.
• Tirzepatide for the Treatment of Obstructive Sleep Apnea and Obesity – Presented by Richard J Schwab, MD - Perelman School of Medicine, University of Pennsylvania, Philadelphia; the Division of Sleep and Circadian Disorders
• Tirzepatide on obstructive sleep apnea-related cardiometabolic risk: secondary outcomes of the SURMOUNT-OSA randomized trial.

Presented by Scott A. Sands, Ph.D - Brigham and Women’s Hospital and Harvard Medical School in Boston, Massachusetts

Moderated by Chana Chin, MD from CHOC Children's/Rady's Children's Health and Bradon Nokes, MD from University of California, San Diego

00:00 — Podcast Introduction & Presentation Overview 
00:15 — Tirzepatide for Obstructive Sleep Apnea and Obesity 
00:47 — SURMOUNT-OSA Trial Design and Patient Population 
01:44 — Primary Endpoints and Secondary Outcome Measures 
02:53 — Baseline Demographics and Clinical Characteristics 
03:52 — Weight Loss Effects and Sleep Apnea Improvement Results 
05:52 — Cardiometabolic Outcomes, Blood Pressure, and Safety Findings 
08:40 — Clinical Discussion: Prescribing Tirzepatide in OSA Practice 
12:03 — Secondary Analysis of Cardiometabolic Risk Mediation 
20:08 — Long-Term Use, Mechanisms of Action, and Audience Q&A

Creators and Guests

Host
Chana Chin, MD
Children's Hospital Orange County Pediatric Pulmonary and Sleep Medicine part of Rady's Children's Health, California, United States -Division of Pediatric Pulmonary and Sleep Medicine and Physiology, Orange, California
Guest
Brandon Nokes, MD
Sleep Medicine Section, Veterans Affairs San Diego Healthcare System, San Diego, California
Guest
Richard J. Schwab, MD
Professor of Medicine (Sleep Medicine) at the Hospital of the University of Pennsylvania
Guest
Scott A. Sands, Ph.D.
Associate Professor of Medicine, Brigham and Women's Hospital and Harvard Medical School

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