Blood Cancer Talks

In this episode, we discuss the management of newly diagnosed DLBCL with Dr. Pallawi Torka. We also have a few bonus ASH22 updates on DLBCL. Links to articles and abstracts discussed in the episode are as follows: 

1. A comprehensive review article on DLBCL:
https://pubmed.ncbi.nlm.nih.gov/33657296/
 
2. RCT testing CHOP vs Three Intensive Regimens in DLBCL:
https://www.nejm.org/doi/full/10.1056/nejm199304083281404 
 
3. RCT testing R-CHOP vs CHOP in DLBCL in older adults:
https://www.nejm.org/doi/full/10.1056/nejmoa011795 
 
4. RCT testing R-CHOP vs CHOP in young (MINT):
https://pubmed.ncbi.nlm.nih.gov/21940214/ 
 
5. PHOENIX trial: R-CHOP +/- Ibrutinib:
https://pubmed.ncbi.nlm.nih.gov/30901302/
 
6. R-CHOP +/- Lenalidomide (ECOG-ACRIN E1412):
https://pubmed.ncbi.nlm.nih.gov/33555941/ 
 
7. R-CHOP vs Pola-R-CHP (POLARIX Trial):
https://www.nejm.org/doi/full/10.1056/NEJMoa2115304
 
8. Comparison of 3 IPI scores in DLBCL:
https://ashpublications.org/blood/article/135/23/2041/452696
 
9. RCT testing R-CHOP vs Dose-Adjusted R-EPOCH (CALGB 50303):
https://ascopubs.org/doi/full/10.1200/JCO.18.01994
 
10. Timing of CNS Prophylaxis in DLBCL:
https://pubmed.ncbi.nlm.nih.gov/34995350/
 
11. RCT testing R-CHOP vs R-CHOP + Bortezomib (REMoDL-B):
https://pubmed.ncbi.nlm.nih.gov/30948276/
 
12. Interim PET in DLBCL? 
https://ashpublications.org/bloodadvances/article/5/9/2375/475850
 
13. RCTs in Limited Stage DLBCL:
 
CHOP x 8 vs CHOP x 3 + XRT (S8736):
https://ascopubs.org/doi/10.1200/JCO.2015.65.4582
 
CHOP x 4 + Rituximab x 6 vs R-CHOP x 6 (FLYER):
https://pubmed.ncbi.nlm.nih.gov/31868632/
 
PET-adapted therapy with R-CHOP (S1001):
https://pubmed.ncbi.nlm.nih.gov/32658627/
 
14.   ASH 2022 updates:
REMoDL-B update: https://ashpublications.org/blood/article/140/Supplement%201/1770/493225
 
Glofitamab update: https://ashpublications.org/blood/article/140/Supplement%201/1062/491024
 
Epcoritamab update: https://ashpublications.org/blood/article/140/Supplement%201/9443/488543

What is Blood Cancer Talks?

This is a podcast on latest advances in the understanding and management of blood cancers. Here, we will bring a wide range of experts within hematologic malignancies to discuss various topics in depth.
Host: Raj Chakraborty, MD from Columbia University, New York, Ashwin Kishtagari, MD, from Vanderbilt University, Nashville, and Edward Cliff, MD, from Harvard University, Boston
Tweet your suggestions and feedback to @rajshekharucms @AshKishtagari @Eddie_Cliff @BloodCancerTalk