In this episode of Hypertrophy: Past and Present, Jake and Chris explore Sig Klein’s early A/B full body routine from the pre-steroid bodybuilding era before examining the claim that elevated myofibrillar protein synthesis blunts the effectiveness of subsequent workouts.
Key topics include:
- Sig Klein’s beginner routine
- The difference between myofibrillar protein synthesis and hypertrophy stimulus
- What comparing one vs three set studies shows us about elevated synthesis timelines
- Why any overlap effect is small (and irrelevant for single-set workouts)
- Why the weekly net stimulus still favours three times per week over two times per week training
What is Hypertrophy Past and Present?
A deep dive into the science of muscle growth. Hosted by Chris Beardsley and Jake Doleschal, this podcast explores hypertrophy training through the lens of pre-steroid era bodybuilding and modern muscle physiology.