Eric Rieger
0:00 Hello gut check project fans and KBMD Health family, I hope that you are having a great day today to host Eric Rieger soon to be joined by my other host, Dr. Kenneth Brown, and Ken Brown KB MD, he's the reason that we get to gut check project. So let's talk a little bit about this episode that's going to follow these announcements. And it's episode number 55. It's continuation of Episode Number 54, where we talked about men's health, specifically how inflammation from various diseases and, and viruses, for instance, can cause erectile dysfunction, and what can be done about it, maybe to recognize it. But what 55 is going to talk about specifically, is the continuation of what we talked about in 5474, we, we kind of delved a little into, you know why inflammation can cause such a problem when two people are trying to be intimate. And now in 55, we're going to talk about what actionable items you can take to hopefully avoid these situations. And if you're experiencing them, maybe you can try this and get over it instead of just always having to turn to pharmaceutical. So anyhow, of course, this is an informative podcast, so we are not your direct healthcare providers, but
just definitely want to share the information. So without wasting any more time, let's get into our sponsors, of course are trying to talk to kids browns, baby, and artron deal is where you're going to get your daily polyphenols, we talk a lot about polyphenols and for good reason. It's what the bacteria in your microbiome in your gut, what they not only wants what they need, in order to provide the post biotic materials and compounds that your body uses every single day to stave off inflammation to stave off disease to give you more energy to protect your telomeres. Why because that can actually be an anti aging mechanism. So regardless, polyphenols are what your body needs. artron teal just happens to be chock full of some of the most stable polyphenols known to man instability matters, because that's how the bacteria is going to get them to break them down and give you what your body wants. So are trying to go to love my tummy.com that's love my tummy.com slash KB MD. Pick up your daily polyphenols today. And of course, unrefined bakery, we've talked about it. And for good reason because unrefined bakery has incredible food and it does not matter if you need to avoid bread because you are a gluten free eater or you're a keto eater or you happen to be paleo. They specialize in those types of diets. And they make the right kinds of breads, desserts, treats, packs, snack mix, all of the things that possibly you thought you couldn't have any more why you adhered to a specific diet, unrefined bakery has unlocked industry and they shipped to all the lower 48 you can go to unrefined bakery.com that's unrefined bakery.com and use code gut check at checkout, save 20% off of your entire first order. Like I said, it's just great food doesn't matter if it's keto, paleo etc. They've got all of the different diet specialties spelled out on there, but they will deliver or shipped to your house. And, you know, check them out unrefined bakery.com delicious food, use code gut check at checkout save 20% Last but not least KB MD health name for Ken brown MD. And this has not only the store that features the three products that Ken has absolutely no problem standing behind Brock elite as well as adriaan deal in KB and D CBD. But you can leave us a message you can inquire a little bit more we're trying to build up a little bit of the content that we have on there but a lot of that's going to come from what it is that you want. So shoot us some more messages I know the way we produce the podcast but we're looking to see if we can't expand on some of that. So go to KB MD health comm check out the store as well as the archived podcasts and if you have any questions or just a comment to say shoot us an email from the button on there and we will do all we can to get back to you as soon as we can. So without wasting any more time go let's go to what I mean go to I'm taking us there we're gonna go to Episode 55 right now on the go jek project
Hello gut check project fans and KBMD health family. It is great
And I'm here with my awesome co host, Dr. Ken Brown, what's going on, man?
Ken Brown
5:04 We got Episode 55, which is part two of the prior episode that we did regarding Men's Health and some erectile dysfunction stuff. And it was really good timing because we got some pretty cool research to go over today, and it's all appropriate. So sit back, learn a little bit about how to protect your penis naturally,
Eric Rieger
5:27 naturally. And so that's what Episode 55 is going to be about a continuation of Episode Number 54. But before we get into that, I think that we, we need to touch on some things that I know that you've been doing with someone who was actually on show.
Ken Brown
5:43 Alright, so we always do a little personal stuff. Yeah. So what's been going on in my life? I got my stem cells. So shout out to Dr. Wade McKenna and his team, which by the way, his staff is awesome. Yeah, they are. They are absolutely amazing. So it's the first time I've ever been sedated. And so I've had two colonoscopies three and das cuppies, two of which I did on myself, which was, which was a gag fest. And I've always been the owl that we put people you put people to sleep right all the time. First time I've ever received propofol. Wow, it was amazing. It was like the coolest thing ever. It's like I just like suddenly two hours labs and Dr. Jerry Lewis shout out to him, it's a way brought him in and they were able to actually float a catheter into my foraminal opening, and I got pictures of this. And injected stem cells after doing a bone marrow harvest on me. I don't remember any of it, no pain. And quite honestly, I'm feeling really good. And it's only the beginning because I'm doing IV infusions now.
Eric Rieger
6:47 So the crazy thing is, is working with you and st talking everyday like we do at work, etc. I saw when you had true deficit, like you really could not extend your right arm, the the tricep really was not responsive. Literally, Brown is standing while we were scoping, you were kind of positioning yourself to work the scope differently than you just normally would, because you'd lost basically faculty in your
Ken Brown
7:14 yard. So what happened is, is that with the disc bulge, it actually compressed the nerve. I've got foraminal which is where the nerve comes out. I've got foraminal stenosis, and I was the swelling that took place from the disc bulge was compressing the nerve, and I didn't have all my usual strength and one of them being these six, seven when I saw Wade the first time Yeah, he was like all here's like, Oh, yeah, yeah, you're not gonna have tricep strength, you're gonna lose your medial pec Rouse, which is exactly right. And he goes, that happened to me years ago, and this is what I did. And Dude, that guy is such a stud. He had a back thing where he did his own bone marrow harvest taught his colleague, because he's the only guy that has done it this much said, this is exactly how you're gonna do it. And did his own bone marrow harvest, made his own stem cells and then had him injected in him? And I didn't want to say that was like 10 years ago or 11 years ago that question, yeah, you know, and he's, he's done well, so if you're somebody that has knee injuries, shoulder, for sure. Knee, low back shoulder, they do this all the time. Neck for me looks like it's going to be a really good success. I'm no pain right now. And I'm gaining function back. It's really it's a it's a humbling experience to go to the gym. Yeah. And be proud that you like can you know, we're usually dumbbells would be? It's this. It's my ego getting in the way. But normally, it would be like, Yeah, I did you know, 110 and each each arm dumbbell incline dumbbells now, I'm just like, sweet. I got 20.
Eric Rieger
8:48 Yeah. In your left hand. And five in your right. Yeah, exactly.
Ken Brown
8:51 Yeah, exactly. So, yeah, so shout out to him. So if anybody has any issues, please. In fact, you You did a revisit of the episode. I did. Yeah. So you did a Facebook post and Instagram pose,
Eric Rieger
9:04 we tried something new. So if we have, we have a different studio now. And honestly, the audience has grown significantly over the last two and a half years. So some of the episodes that we had the old studio there, we didn't really have the network. We didn't have Paul helping us push out things more on the internet. We were more kind of internet radio based back then which we had a great audience there. But now we've kind of got a new or a lot of new viewers. So what we're going to try to do is do some revisits when we can or when this last week, we're both super busy and just couldn't film an episode. So check out the revisit number one, which actually features Dr. Wade McKenna. And we were prompted to do that really, because of what you've been doing.
Ken Brown
9:46 Yeah, absolutely. And if you want to learn a little bit more about stem cells, there's number one look at that episode, because, wow, I did not realize that this has been Wade's background his entire career. And you can look at some TED Talks. With some German doctors because the rules are a little bit more lacks over there. So they've been, they've been researching stem cells a lot longer than we have. It's incredible. I think it's going to be how we're going to treat disease in the future for sure.
Eric Rieger
10:12 100% so I've known Wade for almost two decades. And when when I was covering for him in the O r, it was nothing for him to have a research project going on having someone in the room simply taking samples from the patient that would be spun down and he did all kinds of I mean, he's one of the first doctors to utilize PRP. I mean, it goes back a really, really long time
Ken Brown
10:33 ago. Yeah. For anybody that's wondering, anybody that's worried about anesthesia, I will now get my first hand take on it. I gave my first hand take on what it feels like to get a colonoscopy. I'm so angry at myself, but I believe my crna his name was Corey, Troy. Troy
Eric Rieger
10:49 now try is Troy's. Wade's PA, it's probably Cory. Cory it's
Ken Brown
10:55 probably Cory. Anyways, great guy. Great crna knew you because you guys trained together at some point he trained he trained under you. He told me, he goes, here's what's gonna happen, we're gonna they they got the IV in, because we're gonna go ahead and lay down the gurney here. We're going to harvest the bone where you're going to go to sleep and then we're going to wake you up. You're going to hop over on this floor, oh table go facedown. Then we're going to go ahead, the doctors will come in, they will then float the catheter get in there. Jerry Lewis is going to assist Dr. McKenna. Once they get in the right position, though, inject it, then we will stop the anesthetic and roll your over your wake up and you're going to you're going to do great. I said, awesome. So all of a sudden, I remember being Chuck a little bit now. I'm like, Okay, so we're gonna do that. We just did the bone marrow. Awesome. And I tried to go, where's the flow table? They're like, you're all done. Like, you're all done. I looked up. I'm like, it's been two hours. Holy cow. And I was like, euphoric and felt great. And sort of, whoa, I gotta do this more often. You're not more stem cells anymore.
Eric Rieger
12:04 Just Just relax. Just relaxing
Ken Brown
12:06 anesthesia. Yeah, exactly. Personally, what's going on with you?
Eric Rieger
12:13 We are still remodeling the house. It's interesting to not be in our normal home and having to go back and watch them kind of do demo, etc. But gates just came home from college yesterday. So it's very, very exciting Mac core, still swinging at basketball, and they just finished a big tournament down in San Antonio. They want three or four to get to the championship. So he did great and Murray's social media companies
Ken Brown
12:38 really taken off. That's awesome. As far as my household, Karla won her tournament last weekend, so shout out to Carlos super proud of you did great. The Lucas his last tournament, Costa Rica hurt his heel. And just to be just because I'm a worrywart. I ended up taking them to direct orthopedic care, which actually was kind of impressive. They got us in right away, and they x rayed him and did all this he were in a boot for a week. And now his foots better. Fortunately, nothing was broken. And then same thing with you remodeling. So loida spending a lot of time with my wife loida, looking at white paint. And she keeps asking me, which white should we use? For what room where it's going to go? Yes, what shade of white and honestly, it's all the same to me. I honestly think I'm white colorblind. I clearly see just white. Well, isn't that what it is? Well, not loida. She sees nuances kind of like, kind of like a dragon fly would see like an ultraviolet light or something. I think she sees the nuance of weird whites that I don't get. So I'm just nodding. And I'll just be like that one. And she's like, Are you kidding? That has hints of gray and Oh, honey, that
Eric Rieger
13:53 one is the one.
Ken Brown
13:55 That is not what I want. Right? That we're gonna Yeah. So no,
Eric Rieger
14:00 I understand. I just, I agreed with Marie, that she should pick out all things aesthetic. And she said, Well, you don't want to help. And I said, why would I want to do that? I don't know what we're looking at. And so that's pretty much
Ken Brown
14:15 part of the thing I've been doing for my neck is I've been going to North Dallas Spine Center, where I've been getting traction on my neck. And so I lay down in one of those traction machines where they hold my neck table. Yeah. And they have a TV above me and they keep it on HGTV. And it dawned on me that if you've got nothing going on, HGTV will give you a home renovation. So pretty sure that my daughter Carla and loida can have their own HGTV Home renovation show because that's what they do. Can like you talked about Marie, it's like this tile, that tile looked at this look at this, and it's just like, Oh, this is gonna accent this and it is dizzying. Oh,
Eric Rieger
14:55 it's a specialty and it's a specialty that I have no special skill and
Ken Brown
14:58 no at all. None of All so well that's awesome. So you get it? Yeah. All right. Oh my gosh, I totally forgot about this. I am so pumped. Oh, yeah, that is not so pumped. An article recently came out. You know, like when you're always posting Jeff's have like a guy falling off a skateboard, like a bunch of times, like screwing up. And you're like, isn't this guy awesome? And then I'll post under that. No, Eric, he's not awesome. He really needs lessons in a helmet. And then you'll respond with like, lol. And I just look at that and go. Is he saying lol? Because he now gets that the guy's bad? Or is he saying lol? No, it just adds to a lot of confusion. Well, what does lol mean? Well, it's it's laugh out loud. And it just but you know how you always do that all the time. And I'm always doing that
Eric Rieger
16:00 I know how I always walk into these scenarios that I learned about myself.
Ken Brown
16:06 Anyways, fortunately, shout out to university Central Florida, because we don't got to worry about these confusing social media exchanges that you and I have. Yeah, frequently, all of the time, all of them. So a study was just published may 8, in the Journal of entropy, where University of Central Florida has developed thank goodness, okay, to save our podcast relationship, a newly developed artificial intelligence algorithm that can accurately detect sarcasm in comments written on social media. Yeah,
Eric Rieger
16:44 I want to challenge it now. The
Ken Brown
16:47 dough Miami man or Florida man, I should I shouldn't just key in on Miami right there. Alright, so computer science, researchers at the University of Central Florida have developed a sarcasm detector.
Eric Rieger
16:59 How can that even work?
Ken Brown
17:01 So social media has become a very dominant form of communication for not only people but as it turns out, businesses, companies are always trying to sell products and services. And somebody is always assigned to respond to the comments that people do properly understanding and responding to the call to the customer feedback on social media platforms is critical for success. airgo somebody needs to invent something to help those people understand that your customer is being sarcastic. Not
Eric Rieger
17:31 I don't, I don't know. I mean, I hope that they make a lot of money moving this app out. But who cares? But it's well
Ken Brown
17:37 anyway, so I got really into it because of our exchanges on social media, as I've said multiple times. That's where something called sentiment analysis comes in. This University of Central Florida team developed a technique that accurately detects sarcasm, and social media texts. Effectively, the team taught the computer model to find patterns that often indicate sarcasm, and combine that with teaching the program to correctly pick out cue words in a sentence, that were more likely to indicate sarcasm, they taught the model to do this by feeding it large data sets, then checked its accuracy. And I believe that our exchanges were probably fundamental to their research.
Eric Rieger
18:21 Yeah. Actually, after hearing that, I think I think this is actually really, really important.
Ken Brown
18:28 So I think it's super important also, and I was so interested in this, that I actually contacted the scientists themselves and wanted to speak with them. And I contacted another sarcasm expert. Oh, yeah, yeah, to get another take on the whole field. And so so your wife, Marie commented that sarcasm isn't always easy to identify in conversation.
Eric Rieger
18:49 That's weird that she would say that, because I'm never sarcastic at
Ken Brown
18:52 home. And then the scientists are quoted as so you can imagine. It's pretty challenging for a computer program to do it and do it well. So my own research on this has determined that sarcasm is a difficult thing. And doing it on letting your computer decided is hard.
Eric Rieger
19:12 Yeah, again, I just want to reiterate how important I think this is yes,
Ken Brown
19:17 sarcasm has been a major hurdle since sarcasm relies heavily on vocal tones, facial expression, and gestures that cannot be represented in text. It's important science super important.
Eric Rieger
19:31 This this makes sense to me.
Ken Brown
19:34 In a quote, detecting sarcasm in textual communication is not a trivial task. Dr. akula is quoted or maybe it was Marie, I don't remember which expert was quoting. Now she's often given many lectures on sarcasm, I'm sure that
Eric Rieger
19:52 it could go either way.
Ken Brown
19:53 That's why I went to her and asked her I wanted to interview her. So kudos to University of Central Florida,
Eric Rieger
19:58 and we're getting ready to Get on to this awesome.
Unknown Speaker
20:03 Very important science super important.
Eric Rieger
20:06 Incredibly. That is the weirdest thing that we've ever done. I
Ken Brown
20:12 saw that article and I was like, Oh my gosh, real scientists are spending a lot of time trying to pick out sarcasm and I'm like, wow,
Eric Rieger
20:21 yeah, it sucks that they don't get it.
Ken Brown
20:27 Alright, enough of that that was but it's it's real. You can look it up. It's to me, it's to me. It's just hilarious. That's why we have emojis, you know, the little gestures that people do. Alright, so let's just jump into this episode, Episode 55. To more important, more important topics, health. So remember that last episode was all about how I was seeing more patients, post COVID young patients otherwise healthy as I would start discussing things with them, they would ask me very honestly have Is there any relation to COVID and having erectile dysfunction, because after I've had COVID, I've been having issues. So we started looking into that. And that's what that episode was actually about where we covered how there is this plausible reason for this and how certain studies are showing that they're aggregating some data where people post COVID the long haulers are actually having issues with erectile dysfunction. That was last episode. Check this out. This was just published two days ago.
Eric Rieger
21:32 Oh, wow. So definitely new information since our last episode.
Ken Brown
21:35 Definitely new information. And this is why I said instead of you know, go Florida man go Miami man because out of the University of Miami to Florida studies, one episode out of the University of Miami researchers report COVID-19 found in penile tissue could contribute to erectile dysfunction, really.
Eric Rieger
21:53 So we're like, corpus callosum? What are we talking?
Ken Brown
21:58 Great question. So basically, it's a very small case series, but it is pretty interesting. a urologist out of the University of Miami published this, that COVID 19, or SARS cub to let's say it that way, it can present in the penis tissue long after men recover from the virus. So the widespread blood vessel dysfunction, or endothelial dysfunction, which is what our last episode was all about, right? And that results from COVID-19 infection can contribute to erectile dysfunction. According to this study that was just published in the world Journal of men's health. What this urologist did is he was implanting penile implants, okay, in patients with refractory erectile dysfunction. He had a few patients that were post COVID. And they develop this afterwards. So his idea was that the SARS cov to virus can affect the endothelial and create inflammation, which then can result in erectile dysfunction. What's crazy about this is that we know that you the endothelial lining is the lining of blood vessels, and outlines origins as well. So it can be anywhere in the body. What is really crazy about this is that he took these people that had this prior history COVID and then he took a subset of people that did not but we're coming into the same issues, right? So severe diabetic or somebody that that is having reptile dysfunction, that is, it's devastating enough that you're going to go have surgery for it and have an implant on. So it said this isn't like a big deal. This is. I mean, it's one of those things that I guess, you know, a lot of pharmaceutical money's made on it. A lot of you know, snickering is done with it. But the reality is if you get an infection, and then this affects that it affects your relationships, it affects your mood and all this. What was fascinating is that he did biopsies of the corpus cavernosum cavernosum sorry, yeah, the of the corpus cavernosum. And this is nuts that he sent it off to a research facility where they did electron microscopy on it, and they found a bite virus sitting in the corpus cavernosum consistent with it being SARS cov two hanging out in the corpus cavernosum in patients that had recovered eight months before from COVID-19 and had antibodies,
Eric Rieger
24:27 so it hadn't really gone anywhere. It was basically sitting there dormant that's causing long term infection and problems
Ken Brown
24:32 we don't know that part it this is possibly possibly I should say that Yeah, possibly. And I guess you know, like one of my questions I got a lot of questions for that guy is are you sure that SARS cov two shirts on another virus? Are you sure it's not whatever is your co infection with all these other things, but that is crazy, because that means you clear the virus and you got SARS cov two hanging out in your penis. Well, it's
Eric Rieger
24:56 let's go the other way. He just at least identified that It's possible that there was a virus that happened to look like SARS. But inevitably, it's inflammation that is causing the reptile dysfunction. He thinks he believes that's the connection. So it in essence, it doesn't just have to be SARS, cov. Two, it really could be, how are you going to protect yourself from long term inflammation? Right?
Ken Brown
25:23 You're exactly right. And that's what we're going to talk about today. Okay, this is exactly what we're going to talk about today. Because on so many episodes we discussed, almost, it seems like somehow we get into the fact that inflammation, right chronic inflammation, acute inflammation, it's good chronic inflammation band can create all different kinds of problems. So today, we're going to talk about how to protect your penis naturally. Okay. And I have not heard this anywhere. And so to me, it's a very, very fascinating article about how we're going to do this naturally and using Mother Nature's secret weapon. So let's just recap really quickly the physiology of from the last episode of erectile dysfunction. So if you remember, your brain somehow becomes aroused in any one of the centers, it becomes aroused. And then it releases acetylcholine, where acetylcholine leads to the conversion of arginine to nitric oxide via something that we're going to talk about nitric oxide synthase. The nitric oxide causes vezo dilation of the blood vessels in the corpus cavernosum, which are the spongy tissue in the penis, which then allows for an erection. Ultimately, when you don't need the erection anymore, another enzyme called PD five breaks down the nitric oxide and you go back to your normal state, the etiology of of erectile dysfunction can be psychogenic neurogenic, hormonal, or vasculogenic. And so when you look at all that, keep in mind that almost all of those have an underlying common theme. And that is chronic inflammation,
Eric Rieger
27:09 right? And all of those have to be working for it to work to work.
Ken Brown
27:12 Exactly, exactly. So that's that's what we're gonna look at. So if you have any, if I suggest everybody go look at the last episode, because we went into significant detail about this. And and and we were theorizing almost that getting COVID can do this. And now we just have an article that just came out two days ago, actually showing on biopsy that it's that it, it's not only plausible, but it's probably likely Wow, man, it is really, really wild. I know it's not. So this got me really thinking. After seeing this article, I started thinking about the whole aspect of how do we, after the last podcast if this is going to be a more common theme for so many people or you know, have been infected? Then what can we do from a natural perspective. And today I want to talk about the role of dietary polyphenols in the management of erectile dysfunction. In fact, a very brilliant article was published in 2017, out of a research group out of Africa, where they specifically looked at that, and what they were really looking at is the mechanism of action. And these guys go into great detail about erectile dysfunction, noting how many things can cause it, but also that one of the main underlying themes was inflammation at its root. Okay, so when I get articles, so Angie, and I exchange articles all the time, and when I get articles, I'll briefly read through the abstract. And when somebody says that in the abstract, I'm like, this, this group is speaking our language, right? So what that's what we're going to talk about today is specifically the inflammatory process, and how it leads to this Xay, we're specifically looking at reactive oxygen species, meaning the underlying cause of inflammation is free radicals that can be caused by so many different things. So it doesn't matter if it's arterial, it doesn't matter if it's the hormonal bottom line is if you have inflammation in tissue, how does that cause it? And how can how can it be prevented? Am I making sense?
Eric Rieger
29:28 Yeah, you're making sense essentially, what you're saying his long term inflammation has this byproduct called reacted or I'm sorry, reactive oxygenation species? Is there something that we can do to help clean up that mess so that we can have a better chance of achieving things where inflammation is getting in the way?
Ken Brown
29:43 Absolutely. So when you think about this when you because we always hear about antioxidants? And and people talking about, oh, take this antioxidant, it's a superfood, it's whatever. Yeah, what does that really mean? Well, specifically, inflammation from reactive oxygen species leads to increased production of free wrap. radicals, which ultimately leads to lipid peroxidation, meaning breaking down fat that kicks off more inflammation, protein oxidation, meaning breaking down protein, which kicks off more inflammation, DNA oxidation, which means you actually break down your DNA. And so that's the epi genetic component of some of this stuff. And then decreased synthesis of nitric oxide, and upregulation, of pro inflammatory cytokines.
Eric Rieger
30:32 And that actually is a double whammy. So if you are stopping and just correct me if I'm wrong, but if if you are stopping the production of nitric oxide, you're now decreasing blood flow. And by decreasing blood flow, you're actually allowing whatever happens to be in that area to linger longer. And if you are increasing cytokine release in that area. Now, not only are there pro inflammatory markers now in the area that we don't want them, it's going to take longer for them to be flushed out because there's just simply not enough blood flow.
Ken Brown
31:05 Did you speak with the researchers?
Eric Rieger
31:07 I didn't, because that's
Ken Brown
31:09 spot on. Okay, well, with a little more detail, but it's almost like you had a phone call with them.
Eric Rieger
31:16 After we talked about the sarcasm meter.
Ken Brown
31:23 All right. So you're exactly right. But what's really cool is the actual mechanism and how these polyphenols can help in this process at different stages. So reactive oxygen species cause oxidative stress, because you had an imbalance between the pro oxidants and the antioxidants in a cellular system. So once you tip that damage to the DNA, proteins and lipids and proteins, like I just talked about results in a massive increase in inflammatory cytokines, right? Yes, like you were saying. So in theory, anti oxidants could help protect the endothelium the lining of the corporate cap of the corpus cavernosum by shifting that inflammatory cascade someplace else, the most potent natural anti oxidants are in the form of poly phenol. So this study really reviews the dietary polyphenols and the role they play in the management of erectile dysfunction. From an inflammation perspective.
Eric Rieger
32:33 It's it's fascinating. And then when our most of our viewers know that if you're addressing inflammation with polyphenols, you're not just addressing it for Ed, you're actually going to be addressing it systemically. This is what your body needs to balance everything out.
Ken Brown
32:47 I'm blown away that the more that we do this podcast, the more that I keep uncovering research that has existed, this is 2017 never even heard about this and like holy cow. And it was so good. It's like when we had Charlene on with the celiac stuff correct? Holy cow. Really quick, can you just explain in case somebody is turning tuning in for the first time what a poly phenol is
Eric Rieger
33:07 poly phenol, so the easiest way to find them are knowing that they are the compounds that you find naturally in fruits and vegetables, which are responsible for the colorful fruit, or I'm sorry, the colorful visualization visualizations that you see in you know, green broccoli, or red apples, etc. But what they do when you consume them is they are really what your gut bacteria want for food. They've got specific functions by the time that they get there they arrived, your bacteria know exactly what to do with them. And then they can turn into beneficial products after they're consumed so that you can protect yourself from inflammation, you can give yourself a better chance of anti aging, the bio products of poly phenol, metabolism, I guess you could call it and your colon really pay long term dividends. It's the reason why we've always been coached to drink I'm sorry to drink to eat fruits and vegetables daily. And they're they're the workhorse inside fruit vegetables.
Ken Brown
34:09 Exactly. So what you're going to see in the future, I'll say in the future of research, followed by the future of the market, is that there's a shift going from the probiotics that we're now learning are probably not as quite beneficial as initially touted, and there's lots of marketing behind it. And most research or a lot of researchers are moving away from probiotics to studying these poly phenolic molecules. And you summed it up perfectly, and that's awesome. It's like when I hear you, I'm just like, man, he's so smart. Why would he comment such a silly thing about that skateboarder?
Eric Rieger
34:47 I don't know. I don't know why did that on that social media exchange that we never had.
Ken Brown
34:53 Alright, so what these researchers looked at initially, they said, well, we're gonna we're gonna pull a bunch of studies and And what they looked at was something that that is very interesting to me as well is that they realize that all the studies really involved large, stable polyphenols like pro anthocyanins
Unknown Speaker
35:13 interesting. I think we know a little bit about prime we know a little bit about that,
Ken Brown
35:17 as Eric mentioned, pro anthocyanins are the polyphenols, which are found in the fruits and vegetables with the most vibrant colors, the blueberries, berries and things like that. So that's what they were looking at with these studies, not so much that they were trying to select those. It's that what other people had published. So this study that I'm talking about is like a mini meta analysis. And what a meta analysis is, is when a research group will take data that exists small studies, they'll congregate it, and then they'll do a review and say, This is what the data shows when you put all the data together. Okay. So if you have a couple case series, then you put those together, and that's what so this is like a mini meta analysis, looking at several studies, not several, like many studies. For instance, prior studies have shown that poly females exert their action directly on the endothelial lining of blood vessels. One of the studies cited sums your whole message up where it goes all over the body. This is really true. One of the studies cited found that they radio labeled poly phenol metabolites. Okay, so and then just to break it down, that's what the that's the compound that would exist after the bacteria has taken up all the phenol and broken it down to what it knows is beneficial, right, exactly. So by radio labeling the large poly phenol once it gets broken down, then they can see wherever it goes. And the reason why I say that is because To their surprise, nothing was excreted in the urine. But they did find these polyphenol metabolites in the brain, heart, kidney, spleen, pancreas, prostate, uterus, ovary, Mary glands, testes, bladder, bone, skin, and highly concentrated in all endothelial linings.
Eric Rieger
37:09 So essentially, every organ in all of our blood vessels are highly dependent upon these metabolites.
Ken Brown
37:14 Yeah, and none are essentially none were being excreted through the urine. So as we sit there and talk about this, and we've talked about this, this is when these polyphenols, you take a large, stable poly phenol, right, like abbraccio proanthocyanidin. And if you have a diverse microbial base, your microbiome will break this down into beneficial metabolites that find their way everywhere.
Eric Rieger
37:38 Why if it weren't important, and if your body didn't want it, it would be doing all it could with the reason why you brought up urine is it would be doing all that it could to eliminate them, but it's not doing that.
Ken Brown
37:50 Well. It's not doing that because if it was, so I guess you could think about this, if it were absorbed correctly, you'd pee it out, right? Because all urine is is filtered blood, right? And if it's not absorbed at all, then what you would see is that radio label tracing in the total
Eric Rieger
38:09 Yeah, and still Yeah, yeah.
Ken Brown
38:11 So it's, it's pretty wild. So these authors want to know, well, okay, knowing that it's going to go everywhere. How would this correlate in erectile dysfunction? And more importantly, what are the mechanisms and how it actually does? Okay? So, knowing that these polyphenols can work directly on the endothelial lining, and that inflammation can cause erectile dysfunction. What studies exist to explain how these polyphenols can help directly with erectile dysfunction, so I admire these guys, it's a really thick articles. It was I had to read it like 700 times or something like that.
Eric Rieger
38:51 I think the sarcasm meter has alarmed us that 700 is probably inaccurate. Hold
Ken Brown
38:57 on, let me check the computer. Oh, you're right. The AI says that I was being sarcastic. That's awesome stretch. All right. So first, they referenced many different studies showing how polyphenols have been found to have a direct anti oxidant effect. So when people think about polyphenols, they always refer to it as being potent antioxidants, preventing this oxidative stress. But a more important role that they have determined is that there may be very beneficial indirect effects. And we've talked about these indirect effects on multiple episodes. Absolutely. And so one of these that they went into tremendous detail is a pathway called the n f Kappa beta. Nf Kappa beta. We talked about this on the immune episode. We talked about it when we had the when we had david on broccoli on Yeah, the sulfur fans we've this NF Kappa beta is the is the first domino that gets turned on. So it's almost like a puri trophic phenomenon where it sets off This huge cascade. So if you want to know more about that, and about the cascade, go to our episode on the immune system, because that is where I just drew it all outward shows how complex it is. But basically, to sum it up, it causes this release of inflammatory cytokines just blood turns it all on, polyphenols control his process by controlling the NF Kappa beta. Okay, so it doesn't let NF Kappa beta come in and just say let's throw a party, it's as well hold on, just calm down. It's what down regulates that pathway. In addition, and this is something I did not know, poly phenol is regulated regulate local enzymes that are pro inflammatory, like something called ionos, which is inducible nitric oxide synthase. And I just shout out to Angie, because she said if you're going to do an episode follow up, she sent me a full article. She's like, I've always been confused about this, because sometimes people refer to nitric oxide as being part of the inflammatory cascade. And I'm like, but it's always there. And she's like, this is a great article that summarizes it. As it turns out, there's eyeness, Enos, and US and US is neuro nitric oxide synthase. Wow. Okay. In US is endothelial nitric oxide synthase. I nos is inducible. Okay, so inducible is very important when you have an acute inflammatory response.
Eric Rieger
41:33 Yeah, it's, it's being induced to respond
Ken Brown
41:35 to being induced to respond, okay. But when you turn on certain chronic inflammatory issues, I nos, actually is an enzyme that converts nitric oxide into an inflammatory type molecule are really super cool. So anyways, polyphenols, block, the enzymes like that. And cyclo oxygenase two, or Cox two, right? Do you've ever seen any commercials, we just have commercial all the time about Cox two inhibitors, right. And so it blocks these two enzymes, which, to me is super, super fascinating, because I did not know that it did this on a local level as well. While it's doing this, it's increasing anti inflammation pathways like the and our F two pathway, which we've shown that that is the exact opposite. If you want to think about good guy, bad guy, yeah. And RF to, you know, the old cowboy movies wearing the white hat, the NF Kappa beta is the bad guy wearing the black hat. So you know who's good and who's bad. That's the old timey movies, I remember. That's how that I bring that that's really dating myself, but I'm bringing that up, because that's how I was taught during pathology, about how to read. You're looking at slides. If it's cancer, it basically has all this chromatin staining on top and I remember, my mentor, Dr. Brady would say, look, remember this, when you see a slide and if it's really dark on top, that's a black hat. That's a bad guy. Okay? And if it's darker in the middle, it's it's okay. You have a polyp. It's not cancer yet, but once it does that, so it's just always think about that. So basically, NF Kappa beta, bad NRF, two good pathways that do. One does a whole pathway a bad one does a whole pathway of good polyphenols decreased the bad pathway, and they increase the good pathway, nice and increases inflammatory cytokines or anti inflammatory cytokines like aisle 10. Okay, so that's part of what they get into, which is, which is really, really cool. And then instead of they go into tremendous detail about how this information or the rat of oxygen species creating this inflammatory process, actually, once the NF Kappa beta is turned on, it creates a pop ptosis in the endothelial lining. It's a big word. You
Eric Rieger
43:57 know what that is? It's when cells automatically die, or they are, it's like programmed cell death. They are to they're told that they're, they need to terminate,
Ken Brown
44:05 yeah. So when the NF Kappa beta gets turned on, it goes around, it tells healthy endothelial cells to kill themselves. Yeah, so to speak, which results in cell dying, which then leads to denudation, or sloughing of healthy blood vessel cells, which now needs to be replaced and repaired, which needs to be replaced and repaired, which sometimes that inflammatory process then leads to either scarring or plaque buildup or things like that. Yeah. So if you don't block the inflammatory cascade, it's just a vicious cycle. So this is going to lead to inflammation and fascinating what these guys showed in multiple studies is when you have this a pop, ptosis and denudation. The other thing that you're getting rid of His endothelial nitric oxide synthase,
Eric Rieger
45:04 which is going was going to form nitric oxide, right?
Ken Brown
45:08 Yeah. So its job is to form the good nitric oxide, which helps dilate blood vessels, you actually decrease the amount that's even available.
Eric Rieger
45:17 Now, it's unfortunate, that's not what you want in this particular instance.
Ken Brown
45:20 That's not what you want in this instance at all. And that is not sarcasm. That it No, that is true. That is the truth. Yeah. So anyways, that's enough. So basically, you have you decrease the nos or decrease the amount of nitric oxide that you have. If you stop and think about this, and you know that it goes all over your body. We need blood vessel dilation to keep our blood pressure down to increase the blood flow to our brain. You we have strokes because you blocked the blood flow, we have heart attacks, because you blocked the blood flow, you can have erectile dysfunction because the blood flow is decreased. Correct. So it's all making sense now. So without nitric oxide, you have increased adhesion. So now you have a lining of a blood vessel, which has lost its endothelial and smooth pathway. Yeah. And then now you've got these like ridges, yeah, so as platelets, and leukocytes is your white blood cells and your platelets come swimming through, they're like getting hit and they get, they get hung on, and they get stuck. And this actually causes a release of something called thromboxane. A to because they're like, oh man, we get we need to get out of here, we're stuck. thromboxane a two is a vasoconstrictor. Because if you think of plumbing, you have a big pipe like this, if you're getting decreased flow, if you constrict the pipe, you'll have higher pressure. And so the body's going oh my gosh, I got platelets that are stuck there. Let's release the strongbox saying, Yeah, that's exactly it. I read this, I was like, Oh, shit, yeah, all this stuff is going on with COVID. And people are having strokes, heart attacks, clotting. Now it makes total sense 100%, the inflammatory process is using up your nitric oxide synthase, so that you don't have as much nitric oxide, and then your body's producing a clotting mechanism to overcome that. Yeah. Nobody has discussed this that I've seen. I haven't seen Fauci or anybody talked about that I keep hitting my mic. Get all excited.
Eric Rieger
47:29 Now, I've not seen anyone talk about it from that approach whatsoever. Granted some of this information, some is new as it pertains to COVID and the pandemic, but that the actual process of this though, is not new. There. What they're doing is they're applying some relatively recent knowledge and saying, guys is the same process. We have to get out in front of this.
Ken Brown
47:50 Yeah, absolutely. And I just saw, we've talked about this, but I just saw that the guys that we work with it. And I'll try until they just filed for their they're finalizing their study where they're actually using polyphenols in hospitalized COVID-19 people. So it's public now nice. we've kind of been hiding it. I've been known. I've known about it for over a year now where that's is what they've been trying to do. But they they have their data done. And so now it's public knowledge that they have petitioned to be able to publish this. The data is out publicly yet, but they've at least shown that this is what they're doing. Right. And now it's making sense. Yeah, it doesn't make sense. So to recap, this oxidative stress leads to inflammation, which leads to decrease nitric oxide, and eventually vasoconstriction and clotting. So let's pause for a moment because I feel like I'm just throwing a ton of stuff out there. Well, there's
Eric Rieger
48:49 a lot of stuff. But ultimately, the takeaway through all of this is make certain that you get rest, and that you have polyphenols on board, because that's what your body needs. Really breaking down is why, why do we need this? Why does it work
Ken Brown
49:03 exactly as
Eric Rieger
49:04 you referenced earlier, and it's to bring our attention back? We've been told that we needed probiotics 25 years ago, but they didn't really know why that is, knew that we wanted, or not. Even more importantly, how, yeah, how does it work? We knew that we needed bacteria in the colon, but we didn't really know of taking probiotics was going to really give us the diversity in the colon that we needed to give us the byproducts of the metabolites that our body was wanting. And what we're seeing here with polyphenols is that we know not only why we need them, how they work, and where specifically with erectile dysfunction, we can see that it could actually correct some some damage.
Ken Brown
49:52 Absolutely. Absolutely. Well, well said. Alright, so we're gonna keep moving on because that's not it. It's done. Actually just stop there. Oh, no, there's more. There's more. Do you remember when we had that patient? Who was he is a cancer researcher, okay. And he was talking about how the research he's been doing was looking at blocking arginase enzyme to help as a cancer treatment vaguely. So, essentially, there's and then I had another patient who's a cancer. He's an MD, PhD, and I asked him, I was like, Hey, I had a patient that said, he was Oh, yeah, we've known about that. So he's MD, PhD. So in the research world, they've known about this for a long time. Okay. Basically blocking the enzyme that breaks Argentine
Unknown Speaker
50:42 down, okay.
Ken Brown
50:44 helps your body heal itself.
Unknown Speaker
50:47 Wow.
Ken Brown
50:48 Okay. And I thought that was fascinating, because they're basically, they're basically developing a drug that which is more of like a dietary supplement to treat cancer. Fascinating.
Eric Rieger
50:59 Yeah, it is
Ken Brown
50:59 super cool. So lots of research is going on in the cancer world regarding arginase inhibitors, and then doesn't take long for the pharmaceutical industry to realize there's money and other things. Sure. So there's lots of research going on in the world of erectile dysfunction, trying to use arginase inhibitors for erectile dysfunction. Big money, definitely big, big money. So as it turns out, there are studies out there that have shown that Polly females actually have a strong arginase and Ace to inhibition as well.
Eric Rieger
51:37 And I think this is important, though, to point out because there's a big distinction, at least in our experience of the motivations behind pharmaceuticals, again, is to just find something to block that one enzyme arginase. polyphenols are really the far more natural way for your body to have the things at its arsenal and its disposal to use when needed, which is a much different approach, give your body the tools if I if if I needed a lug nut taken off of my of the wheel, so you change the tire, that'd be great to have that lug nut, you know, wrench. But then later on as a screw comes loose in the car, or I need to any I need to get my spark plugs or something else like that, I would much rather have the toolbox that had the lug nut wrench, the gap for the spark plug and the screwdriver. Versus well now I've got to try to fix my spark plugs with this wrench, and it's not gonna work
Ken Brown
52:36 100%. So think about this, if you develop a drug that is purely an arginase inhibitor. Yeah, but you don't have any nitric oxide synthase. To convert the arginase to nitric oxide, there's,
Eric Rieger
52:47 there's no there's no balance in what you're what you're doing. There's no balance at all in that give your body the fuel to make use from the tool chest as it needs.
Ken Brown
52:58 Absolutely. There have been studies that have shown this, they cite several different studies. But one in particular that I just want to bring up is a polyphenol called Moringa. I'm only bringing this up because we will be discussing Moringa on a future episode. Because it ties in I'm just I love doing this podcast because I learned a lot. I love it when anybody else listens to it, and they comment on it. We do get a lot of emails, and I'm loving that. But the reality is that it's fascinating how many things just come together? Yeah, when you're like, Oh my gosh, nobody's put this to this. Nobody's put this to this. So when I say that we're gonna talk about Marina in the future. Like in the very near future, I got some really cool stuff that I've come across. But there's, we can't, there's only so much we can discuss and on one episode at a time. So when we're looking at all this, and we said in the very beginning of this episode, that inflammation is the root cause. Well, you have to bring up will then address some of that, like, Are there any studies that show when somebody has chronic disease?
Eric Rieger
54:08 for erectile dysfunction, there's tons of that, like diabetes
Ken Brown
54:12 for Oh, for instance. There was a study where it looked at how a poly phenol from a lactic acid, improved erections and diabetic rats. And they were able to demonstrate in these diabetic rats, they induced diabetes in them that this was done through an inhibition of the reactive oxygen species directly and locally in the corpus cavernosum. So diabetes is one disease, okay. There was another study that ingesting pomegranate polyphenols improved penile vasodilation in rats, that they caused severe arterial genic erectile dysfunction, so vascular disease, and this One, after administration of polyphenols they documented increased intra cavernosa blood flow. So increased blood flow to the penis, compared to the untreated rats with the same vascular disease, in other words, coronary artery disease. And the key point in this study was that the decrease in reactive oxygen species allowed an increase in nitric oxide to stick around long enough to override the lack of blood flow. I'll say it again. Wow, the that whole process that I just talked about, where you have inflammation, reactive oxygen species leading to the inflammation, causing the NF Kappa beta to turn on, which leads to vasoconstriction. As it turns out, by giving the poly phenol it allows the nitric oxide to stick around long enough and go like Braveheart hold. I was able to hold open the vessels and be like, we're gonna get an erection one way or the other. Just paint my face blue. Let's go. Let's do it. Yeah, no,
Eric Rieger
56:01 I get it. Hey, I find that interesting, though, too, because it's once again, it's the antithesis is how we got to the problem in the first place. You mentioned COPD, or coronary artery disease, which also include probably similar diseases like peripheral vascular disease, having a problem but what inevitably do they think leads to those, those deposits or those blockages NCD And usually, it's long term inflammation processes, and it can be kicked off by anything can be kicked off by long term sleep apnea, etc. But you end up being deficient in molecules that your body wants to basically control that inflammation. It happens every single time. It's the
Ken Brown
56:45 tipping point, right? When you don't have enough antioxid antioxidants and the pro oxidants turn enough on the NF Kappa beta. Oh, you're on the wrong way.
Eric Rieger
56:56 And then that's a long explanation in and of itself. I'm just highlighting that. That that is ca D is just another instance where what we needed to control systemic or even local inflammation is deficient in the molecules needed to prevent that accumulation that blockage.
Ken Brown
57:13 Do you remember and stepbrothers when they, after they, when they met up at the Catalina wine mixer and he goes, are you still? Are you still? Whatever he said karate chop and watermelons. Whatever he said, he goes, No. And he was but I am taking a daily aspirin. He's like, that's the smart thing to do thing. Yeah. Somewhere in there was the whole enterprise rent a car, they teach you to be your own boss. But anyways, so the whole idea of taking an aspirin a day? Is it because it blocks the the cyclooxygenase pathway? Or is it the antiplatelet pathway? Or oh my gosh, really? aspirin is an anti inflammatories? Yeah,
Eric Rieger
57:55 that's exactly what it is. And it does. It's an anti inflammatory because it was blocking Cox
Unknown Speaker
58:00 Right. Yeah.
Eric Rieger
58:01 So what is polyphenols do
Ken Brown
58:03 co x by the way? Yeah,
Eric Rieger
58:05 yes. It's we're on that subject are we highlight the early in the show? Have you heard him say that's nuts twice? I heard that. So.
Ken Brown
58:18 Yeah, so let's think about that. Like, like, my, everything was just going off in me. I was just like, wait a minute. That's why what we showed that taking an aspirin antiplatelet activity of Plavix. Why do we put people on Plavix to be antiplatelet without treating the underlying inflammatory process?
Eric Rieger
58:37 Yeah, I mean, I think our society just become really accustomed to turning to the drug, which really is only targeting one small thing instead of giving your body the opportunity to correct the more universal problem. Because let's face it, if you're on a antiplatelet therapy like Plavix, of course, it can be saving your life if you had a standard etc. I'm not saying don't take Plavix. However, you do have side effects that come from that that you you can bruise easier. you bleed out you have a scrape. I mean, it's just it's fun.
Ken Brown
59:10 Alright, so we know that you have to if you have a cardiac event, cardiologist goes in get a lot of Cardiology friends and they place a stent open up your artery increases the blood flow problem is the stent has little ridges on it. Yep. And that's where platelets can it he's exact same thing is happening when you do a nude. Oh, yeah,
Eric Rieger
59:29 vessel. That's right.
Ken Brown
59:30 Yeah. You create little ridges, that platelets will stay 100%. Yeah. And then that's all from inflammation. That's all from inflammation. And then finally, in another study using a poly phenol combo from grapes, apples and saffron, they demonstrated that an indirect mechanism in this case, by activating the sirtuin one pathway, we haven't mentioned that yet, but we've talked about it before the sirtuin one pathway which resulted in decreased apoptosis of the endothelium and resistance towards oxidative stress. If the cert diet rings a bell with anybody, that's because a Delta the cert diet lost a bunch of weight and everybody kept talking about the cert diet. It's a poly phenol that yeah, it turns on the serotonins, which basically function to block this stuff that we're talking about a pop ptosis denudation, reactive oxygen species, definitely. So super. Alright, so the bottom line is polyphenols are badass in the natural prevention of erectile dysfunction. And it was shown to do this by multiple mechanisms. Let's just go over the mechanisms super fast. Number one direct anti oxidant effect, right? So it is the antioxidant to protect the pro oxidants that are going on reactive oxygen species. It increases nitric oxide by decreasing the enzyme inducible nitric oxide. So that's the bad one. And it was actually shown to increase nitric oxide synthase because that goes down with inflammation. Correct? Number three, inhibiting arginase. So
Eric Rieger
1:01:14 we didn't talk about this earlier, I think we're gonna get sidetracked. But why is arginine important for nitric oxide production. So if we break down arginine before it has an opportunity to be used by by nitric oxide synthase, then obviously it's just done a fuel or components to make
Ken Brown
1:01:32 nitric oxide correct 100%. So in the prior episode, we talked about it in detail where acetylcholine turns on this ability for arginine to get moved through an enzymatic pathway using nitric oxide synthase. that converts Argentine into nitric oxide, right. So that's why it's so important. So if you don't have enough Argentine, then even if you're doing well, and your body wants to have an erection, it needs this substrate. Yeah. And if your body is breaking it down all the time, because arginase goes up during inflammation, then you don't even have the substrate to do it with
Eric Rieger
1:02:08 just not enough fuel.
Ken Brown
1:02:10 There's not enough fuel, that's that's the best way to put it. Number four, it blocks pro inflammatory pathways like NF Kappa beta. And that, that just leads to blackhat. That's the black hat that just leads to decrease in TNF alpha and interleukin six and all these other inflammatory cytokines. Then it also turns on anti inflammatory pathways through the NRF two pathway, which is the white hat, which turns on the shuts down NF Kappa beta and turns on a whole host of other anti inflammatory processes. And then finally, number we're on six it activates the cert one pathway leading to less a pop ptosis. And it also helps with protecting the reactive oxygen species a pop ptosis creating the bumpy lining the denudation. So Mother Nature secret weapon new and improved for erectile dysfunction. We talked about it for other things, but we didn't really discuss it. Regarding this.
Eric Rieger
1:03:11 I mean, at this point at this point. If you've been on the fence on Should I take polyphenols but you're not on the fence if if you like to have sex? And the answer is yes. If the answer's no, then I mean keep keep skipping. But if you want to protect an intimate love life, then polyphenols are critically important when they just aren't and they always have been it's this isn't new.
Ken Brown
1:03:37 Well, this isn't new, and we just discussed the study out of Miami. We're now we're gonna start we're gonna see a lot more people younger people showing up saying I have erectile dysfunction. What's going on?
Eric Rieger
1:03:47 Yeah, it's gonna be more devastating. The younger that you Oh, one is it's not normal.
Ken Brown
1:03:53 That's not normal. The 100% and it's just one of those things. Nobody. Well, not well, no, I'll say nobody wants to talk about it. Yeah, nobody talks about it until Mike Ditka went on a Viagra commercial. It was like wolf ditches talk about it, then. I guess we can talk about it a little bit more. Oh, yeah. Remember that?
Eric Rieger
1:04:08 Yeah. And then it thank thanks to them honestly, because it broke the barrier to where they became commonplace. I don't remember anybody talking about
Ken Brown
1:04:16 it publicly. No. And then if you're sitting there just going okay, you're done with these polyphenols. Which one that I talked about? You talked about grape. You talked about pomegranate, you talked about Moringa. The bottom line is the larger the more stable poly phenol you have. It will be broken down into the metabolites, the post biotics and we talked about on a prior episode with Silvia her research was she's PhD from Spain. Shout out to her for English being distant second language I think she speaks four languages also. But English being her last to learn and she came on the show and discuss it. Her research show that when you take a large table polyphenol like abbraccio and chestnut, your colonic bacteria, she fermented it, she digested it and fermented it, meaning that it was the metabolites, you kick off all these different smaller phenolic compounds that people try to study like allergic acid, like root and like reservatrol, like curcumin. It's incredible. You give your body what it wants you and we always talk about, you know, get it in your diet first. So eat a very colorful plate, you're going to get that. But to get the same amount of polyphenols, proanthocyanidins in five bowls of berries, it's equivalent to two doses of autoruns. Hill, it's correct. So from poly poly phenol content to poly phenol content of proanthocyanidin. That's, that's where it comes in. Yeah, and that's why I'm so passionate about it and
Eric Rieger
1:05:49 poly finos we made a reference or I made reference earlier to having having a toolbox. So certain polyphenols individually, they're great, they're great for you. But that may just be a small tool bag. And a larger molecule poly phenol like a pro anthocyanin is really like the entire tool chest. Regardless, you're giving your body all of the tools that it needs or several of the tools that it needs in order to make the right metabolites that you're in need of.
Ken Brown
1:06:15 Yeah, so awesome. Do you want to recap this real quick? Because it's that
Eric Rieger
1:06:22 man do I want to do it right now?
Ken Brown
1:06:27 So I got one last question. Which which white? Do you like better?
Unknown Speaker
1:06:37 here
Ken Brown
1:06:37 Why would you choose that? works at all? Yeah, Episode 55. In the books we covered both sarcasm and directions
Eric Rieger
1:06:46 we did we covered sarcastic directions. Thank y'all so much for joining us and we look forward to Episode 56 and that's actually a mystery we're gonna find out what that topic Yeah, that
Ken Brown
1:06:58 one's gonna be a bit of a mystery. So as always, everything that we're talking about on this show, I am a physician Eric is a crna we do treat people on a regular basis but we are not your doctor and unless you are my patient and you're listening to this. So please do not take this as medical advice. This is a show it is for entertainment. And we are also trying to educate so in that light, we would love it if you would share this if you would subscribe. And if you would, you know like it post a comment whatever, so that we can run it through our AI software to find out if you're being sarcastic.
Eric Rieger
1:07:31 Definitely do that we want to run it through our AI software. I thank y'all so much please like and share. Honestly this type of topic kind of gets shadow banned on certain platforms. So if you're ever going to share an episode, please share this one and episode number 55. And of course check out our first ever revisit with Dr. Wade McKinnon because this guy here went and visited him for some stem cell treatment. Thanks everybody. Bye bye.