The Emerging Biotech Leader

Being Chief Medical Officer at an emerging biotech company can feel like draining the ocean with a dixie cup. No CMO can fulfill the duties of the medical office alone. Building a solid team is critical.

Learn about building a team from Dr. Suku Nagendran.

Show Notes

Being Chief Medical Officer at an emerging biotech company can feel like draining the ocean with a dixie cup. No CMO can fulfill the duties of the medical office alone. Building a solid team is critical.

In this episode, SSI Strategy’s hosts Dr. Ramin Farhood, Vice President of Medical Affairs, and Kim Kushner, Senior VP, spoke with Dr. Suku Nagendran, President of R&D and Chief Medical Officer (CMO) at Jaguar Gene Therapy. They discuss the challenges and rewards of being a CMO.

Dr. Negendran was formerly the CMO at Avexis. A gene therapy start-up that achieved unicorn status and delivered a life-saving drug for babies suffering from Spinal Muscular Atrophy Type 1. He shares insights from his time at Avexis that emerging CMOs can learn from as they navigate the complexities of the current biotech startup climate.


The Takeaway:
  • Always keep the mission in mind. You’re trying to help patients. Stray from that, and you could hurt patients and your company.
  • You can’t know everything, so you need your team's knowledge, openness, and honesty to develop the right solutions for your patients.
  • Regardless of your company’s share price, you must do the right thing. Speak your mind, and challenge others. Courage counts. 
  • Trust in partnerships. Outside partners can act as an “angel on your shoulder” to identify gaps.

Diving deeper: 

Dr. Nagendran learned from years of experience at a large corporation that a good CMO must juggle multiple job functions, manage multiple stakeholder concerns, and deliver fast results. The same lessons apply at start-ups like Jaguar and Avexis, but you have to accomplish it with fewer resources. In either case, the most efficient way to get all this done is to build a well-coordinated team around you. 

The CMO role is no job for shrinking violets. You need confidence in yourself and the people around you. If you don’t have internal resources, look outside your organization. 

For example, clinical development plans for gene therapies typically take about a year to complete. While at Avexis, Dr. Nagendran worked with SSI Strategy, and together, they completed the clinical development plan in 10 days. 

That’s the power of finding the right partners within and outside the organization.


Pro tips for Chief Medical Officers

  1. Find your “true North” – be true to yourself, your patients, and your mission.
  2. Remember to be humble; You can’t do it all yourself.
  3. Don’t be shy about asking for help.
  4. Work on self-awareness, know your strong points, and build a network and team to fill the gaps.
  5. Take calculated risks.
  6. Leave time for yourself and your family—a burnt-out CMO is ineffective.
  7. Learn how to manage the dynamics of your leadership team and their diverse backgrounds and personalities.
  8. Manage disagreement, listen, make adjustments, and then make your decision.

Memorable quote: 
“I’m a nobody who became a somebody because of all the people around me.”


INTERESTING LINKS
jaguargenetherapy.com




What is The Emerging Biotech Leader?

Biotech—it's complicated.

A successful product launch requires grit, determination, and clear direction.

But let’s be real, the path to launch isn’t a straight one.

There are curves, hard turns, and dead ends.

Here’s the good news, you don’t have to navigate the complexities alone.

Welcome to The Emerging Biotech Leader, where we help biotech leaders maximize the value of their therapeutics from clinical development to product launch.

Welcome to The Emerging Biotech Leader,

where we help biotech leaders

maximize the value of their therapeutics

from clinical development to product launch.

We’re your hosts,

I'm Kim Kushner.

And I'm Ramin Farhood.

We are here to help

you navigate the pitfalls of the biotech industry

and illuminate the path forward.

For those in the gene therapy space,

you've probably heard of him.

Dr. Suku Nagendran is quite the household name.

Starting his career practicing internal medicine in Arizona,

he joined the industry in big names,

like Pfizer, DSI, Quest Diagnostics,

before the leap into biotech.

He was the chief medical officer of AveXis gene therapies.

He's now the president of R and D at Jaguar Gene Therapies

and he's serving on boards across the industry.

Suku, welcome to the podcast.

To get us started, we wanna hear more about AveXis.

It's the darling of the industry

and you've had a great experience there.

Can you tell us more about it?

Thank you, Kim, for this invitation

to talk to you all about my experience

in the world of biotech and gene therapy.

Before I get into AveXis, what I'd like to start by saying

is that I wake up every day and pinch myself

for now being considered an expert in gene therapy,

given that my background is internal medicine

and I always considered myself a country doc.

So as you highlighted, I've spent almost 24 years now

in the pharma biotech diagnostic sector.

And during that course of my career

is when I ran into Sean Nolan, who was at Reata with me,

which is also pretty well-known biotech.

And it's that connection that actually took me to AveXis.

So in 2015, when I was at Quest Diagnostics

heading the medical organization

and actually being quite happy and satisfied

with what I was doing, Sean calls me up

and says, Hey, you know, I just became CEO

of this company called AveXis,

and you have to go talk to Jerry Mendell

and Brian Kaspar at Nationwide Children's Hospital,

because he thought that they had something

that could be transformative.

So I went out to Nationwide Children's Hospital

in Columbus, Ohio, looked at the data,

looked at their early animal data,

as well as the data that they had from the clinic

in a horrible disease

called spinal muscular atrophy type 1,

and I was blown away.

The one-to-one translation

of the preclinical work into the clinic,

and the fact that this was a devastating disease,

and the fact that I had never seen this kind

of data translation from the animal into the human

gave me this gut feeling

that this could eventually become a cure.

So on my way out, when I left the Nationwide,

I called Sean Nolan, and I said, “I'm in.”

"I'm more than happy to join you as chief medical officer

because I think we can do something magical

and transformative for patients."

Incredible.

So was it the data that really made you decide

to take the leap?

It sounds like a lot of people told you not to go

to AveXis at the early days,

a lot of your mentors and people you trusted.

What made you decide to move over?

It wasn't just the data.

It is the translation of the data.

So what I'm talking about is that the Delta 7 mouse model

had significant death rates at 14 days.

And the fact that these mice lived quite long,

and on top of that, the fact that in the human beings

that they had actually dosed the first six children

were doing things that were not expected.

This gave me significant hope.

And yes, many people, including folks

at the company I was working for, said, "Hey,

you're gonna take a very big risk in going to a startup

that is still not that well-funded."

But something told me based on my prior experiences

in drug development,

this gene therapy program could really transform life.

So I had the confidence not only in what I had seen

from Jerry Mendell's work,

but also I had confidence in Sean.

Because Sean Nolan historically

had done some very interesting work

in other disease states in biotech.

And I felt that the team, if it came together,

could really make a difference for patients.

So it was not just the translation of the data.

It was also the leadership team that you were joining

and the confidence and the people

that you were doing it with that you really thought

that something was special at AveXis.

Absolutely.

So that is something I would always highlight

to anyone who wants to get into biotech

and play a leadership role,

which includes being a chief medical officer.

That is that not only do you have to have confidence

in yourself, you have to have self-awareness of your gaps,

but you also have to have the right people around you.

And I want to throw this quote in,

which I always remind many of my team members

and also even my superiors around me,

that I consider myself a nobody who is now a somebody

because of everybody around me.

It is my team and the people around me

who have helped me and others be successful.

So on that note, Suku, tell us a little bit

what it was like to be the CMO at AveXis,

a small biotech company.

I believe you were in the first maybe 30, 40 employees

that the company has hired.

And you were coming from big pharma.

You were coming from diagnostic.

All of a sudden, you were put

into this fast-paced biotech gene therapy.

Tell us a little bit more about that

and how was it like to be a CMO,

some of the challenges you had to face.

So Ramin, that's a very good and important question

because it does give many people insights

into what it is like to start in an early-stage company.

So I'll give you my first day.

I get to Chicago, I walk into this tiny office,

and Sean points me to a corner desk with a chair

and says, "That's your office."

So that was my first day.

And I still remember thinking to myself

at the end of the day, what did I sign up for, okay?

Because I was actually I think in the first 15 employees,

and I didn't really have much of a team.

I had a couple of junior team members

and there was a ton of work to do

because the program was already

in the early stages of the clinic

and we were trying to execute on this program

with Nationwide Children's Hospital, and at the same time,

we were also planning to put together a regulatory package

to try to move this program forward,

given how the data was accumulating.

And we were also talking

about actually putting this company together

and growing it rapidly but also taking it public.

So what I would highlight is a chief medical officer

and his or her role at a early-stage biotech

can be multifold, okay?

So you will have external facing roles

and internal facing roles.

External facing roles,

especially if you're good at communicating data

and talking to different types of audiences,

you and the CEO will be out there quite a lot,

which takes up all day.

Then at two in the morning,

you're running the internal operations,

which usually include anything from preclinical

to clinical development to clinical operations

to planning commercialization,

which includes medical affairs.

So it is a lot of work, a lot of stress.

And frankly, you have to be quite self-aware

to manage through all of this.

Otherwise, it becomes incredibly challenging

to be successful in that kind of environment.

And you have multiple different stakeholders

that it also becomes very challenging

for each one have a different need,

each one have a different agenda, different focus area.

How did you manage the board at that time when you joined?

I believe you were tasked to pull together quickly

a clinical development plan in a very short period of time

and there was a lot of pressure on that.

I remember those times.

And how did you end up managing that?

So that is another important question, Ramin.

So before I went to AveXis,

a good clinical development plan usually took up to a year

in most companies,

because obviously, I worked for bigger companies.

My first day, Sean brings me into his office

and says, "Look, I need a clinical development plan ASAP

to present to the board, such that we can get funding

and move this program forward rapidly."

So essentially, I had 10 days or less.

So guess who I called? I called you guys, SSI.

I talked to Doug, I talked to Madhav,

and we all got together

at the local Parsippany New Jersey office

with a crack team of neurologists

and others who were really experienced in drug development,

including biostatisticians.

And frankly, I still cannot believe we pulled this off.

We put together

a full clinical development plan for a gene therapy program

in a neurologic space, spinal muscular atrophy,

within seven to 10 days.

And then we took it back to Sean,

the executive team and the board, and we presented it.

And then most of it got executed when I was at AveXis.

Now, the point I will make here again

is, remember, I was not a neurologist,

I was not an expert in gene therapy,

and I was not an expert in spinal muscular atrophy.

So what I did wasn't what I did.

It was what the team did with me.

That includes the SSI team.

And then the rest became history

because, as many of you know, this company flourished

over a course of 2 1/2 years when we were there

where the data that we generated

in the clinic was incredible.

This became a life-saving product.

And we took this company public in February '16.

And as all of you know, in April of '18,

Novartis purchased us for $8.7 billion.

So this is a experience that I consider one

in many lifetimes.

And it's what one would consider a unicorn biotech.

So to kind of wrap this up, though,

again, that plan could not have been put together

if not for the team that worked with me from SSI and others.

So a lot of compliments to everyone

who worked on this program.

Suku, tell us a little bit about the leadership team

at AveXis, and the dynamic of the leadership team,

and your interactions with the group there,

and your takeaways.

And how were you able to kinda overcome some

of the challenges that you initially had?

So I had a very diverse leadership team,

people with very different experiences

from clinical development to clinical operations

to medical affairs to health economics, et cetera.

And one cardinal rule that I had with all of you,

which as, Ramin, you are part of my leadership team there,

was that I would remind everybody,

"Yes, I'm the chief medical officer,

but there's a lot that I don't know.

The reason I have all of you with me

and I hired all of you is to make sure we do far better

than myself leading this team and making decisions."

I wanted all of you to be very candid with me,

which I encouraged, and also challenge me appropriately

where when I made certain decisions,

if you all thought that was not the right decision,

let's talk this through

and then come up with the right solutions

to move the program forward for patients.

And I found that open, honest, transparent conversations

with my leadership team paid dividends

because it not only enabled us

to be even better than what we were,

but it also enabled us to execute on a program

that was moving through at warp speed.

So as all of you know, we delivered results every quarter

for AveXis that I've never seen any other company do

in my experience.

And that was partially because of us working together

in an open, honest, transparent manner,

focusing on the patient.

And I would also add that I encouraged,

and Sean Nolan was very good at this, too,

in bringing together diverse personalities

where we could have disagreements in the room, right,

to move a program or a decision forward,

but then we left the room, we held hands together

as a cross-functional team, and represented the company

and the patients in the best manner possible.

So disagreements in an appropriate venue

was always encouraged.

And this open, honest conversations are what led

to the strength of the team, such that diverse expertise

and experiences could come together

and work together to advance a gene therapy program

that was transformative for patients.

And the open, honest conversation

is not always an easy one to have

because you never know how the other parties

are going to react or if they agree with you or not.

And it's not as easy as...

You would think that it's an open and honest conversation,

but the other parties may not quite see it that way.

They may get defensive or they may have other thoughts.

And how do you overcome at that point when people come back

and say, "Oh, absolutely not, I fully disagree with you"?

How do you manage that, especially at the executive level?

So another important question, Ramin, right?

So one thing, if you remember, is when we got together

as a cross-functional leadership team within medical,

we had disagreements, right?

And eventually, sometimes I would tell all of you,

"I've heard all of you," right?

"And I have an opinion,

and I am going to adjust some of my decisions,

but now I am in the position

where I have to make a decision."

So actually, I would say this was one of my strengths.

I, sadly, for the good of the company,

never had a problem making a decision, okay?

So I would make a decision and run with it

because there were times we didn't have time

to sit and pontificate.

So what I'm getting at is, as a chief medical officer,

you have to mature to a point

where you're willing to encourage your leadership team

to share their thoughts, share their disagreements,

then you have to take all that information,

process it and digest it,

and then make decisions sometimes very quickly,

especially when you're running clinical trials

and you're dealing with patient safety.

As you know, in gene therapy programs,

there have been issues around patient safety.

And we were a pioneer when it comes to AveXis.

And there were a lot of things I saw

from a safety standpoint

that had to be appropriately managed.

You had to get in front of them.

Whether it was managing with appropriate therapeutics,

wrap around with the principal investigator working

on the program, using more prednisolone

or immunomodulatory agents to manage the patients,

these were all difficult decisions that were instinctive

based on collective leadership feedback,

where eventually my experience drove some of those decisions

with the PI as to do what was right for the patient.

So again, there is no cookbook answer

to your question, Ramin,

but I think there are many principles based

on what I just said.

'Cause again, you have to be confident

and comfortable in yourself as a chief medical officer

in having those open conversations

with your leadership team,

and then having the ability to make the right decisions

that sometimes only retrospectively you know

you made the right decision.

And that teaches you for the future, okay?

Great point about decision-making.

And I think your earlier points

kind of culminating some of this are around the need

to have a really productive culture

where you can have healthy pushback across the teams.

And it sounds like there was also a deep sense of trust

in your collaborative cross-functional partners

and what their expertise was

and how you could work together.

And I definitely see that as a critical point

in the clients that we're working with.

But Suku, it sounds like that was part

of the secret sauce that at AveXis in particular.

No, absolutely, Kim.

And I would also highlight that when you work

with multiple biotech companies and customers,

something many of these companies have to do is,

and at a leadership level, is actually be self-aware

and look within, and be open and honest

when it comes to some of the gaps they may have

and where they actually need help.

Because many a time, I see companies fail

because they don't do so

and they're not honest with themselves.

And this is why many a time I have reached out to SSI

to bring you all in to be kind of the person on my other,

as I say, the person on my shoulder who points out,

"Hey, you have a problem here.

You better pay attention to that.

Hey, you have a problem here."

'Cause sometimes, internally,

they won't point that out to you.

But people from SSI have been very courageous

when it comes to working with me in pointing out those gaps

and helping me sometimes address those gaps

for the greater advancement of the company

and our programs for patients.

Right, absolutely.

And I think one of the other secret sauce

that you've brought up a few times,

they were really the patients at AveXis.

We were so laser-focused on these babies, right?

At the time that we were coming to the market,

there was just only one other product in the market.

And these babies were basically dying

before they were two years old.

So I think the whole company,

especially being such a small company,

we were so much in touch and laser-focused on these babies,

their parents, and what they go through,

and our partnership with the advocacy group,

that it translated to our everyday being

and decision-making,

which I think was also very, very unique at AveXis.

Maybe one other question.

During that time, what would you think was one

of your best decision or the leadership best decision?

And what would you consider to be not,

maybe not such a smart decision looking back?

What do you think those would be?

So from a decision-making standpoint,

it was the team that I built.

Because I knew what I was good at.

Thankfully, I had been in the industry long enough

and I had taken a lot of punches, okay?

So I had been involved

with some mega drug development challenges.

Some of them which were big pharma companies

where it really makes you self-aware

of what to look out for very early.

So I was able to hire people in clinical development,

clinical operations, and also, medical affairs,

given how quickly this product was moving

through the developmental life cycle to fill my gaps

and to actually assist me in doing the work.

'Cause I spent a lot of time during the day with Sean Nolan

and others talking to investors, going to Wall Street,

preparing for quarterly meetings, okay?

Some of the mistakes I made during that period,

which I still regret, is not taking time out for myself.

That 2 1/2 years that I spent, I worked so hard

where I never got any sleep,

I had no time sometimes for my home, my family.

Now, I was lucky that this was only a 2 1/2-year period,

but frankly, it felt like I was doing this for 10 years

by the time I exited the company after Novartis acquired us.

So that's one thing I would remind anyone

in a leadership role, including as a chief medical officer,

eventually, when you go on and move on to another world,

people are not going to put on my tombstone,

"Hey, this guy worked for AveXis," right?

It's really how your family remembers you

and your close friends remember you.

So this is part of reality.

So I always remind people around me, career is great,

but always remember there is much more to your life

than just your career, okay?

I think it's a really important point.

And one of the other questions that Ramin

and I have really wanted to dig into a little bit, actually,

we weren't gonna ask this question

with regard to your family,

but would love to hear the perspective from your family

as well as professionally.

You've gotten a bit of a reputation for being a cowboy

and taking some calculated risks

and being really comfortable with that

where many other people wouldn't be.

How has that influenced the path that you've been on,

the decisions you made,

whether it was at AveXis or elsewhere?

How has that influenced your family life

and some of those connections?

Most of what I've done in my career I could not have done

without the support of my family and my wife, Ann.

If she hadn't encouraged me to take this chance with AveXis,

I probably would not have.

'Cause as I said-

So she's like a cowgirl, too, huh?

Well, she has good instincts, right?

I mean, you have to have a partner

who keeps you grounded, right?

So at Quest Diagnostics, as I said, I was very happy.

I was making a good living and my career was set.

And actually, even the CEO there

was absolutely shocked when I left.

But sometimes, as people say, you have instinct

and you have to take a calculated risk.

And you have a family,

people around you have to support you.

And I would say my wife, Ann, was very supportive.

And frankly, it paid off, right?

It paid off for patients. It paid off for the family.

It paid off for my children, the three boys,

who also have been very supportive.

They have watched my career with absolute fascination

and they still chuckle about the AveXis days,

because obviously, that kind of experience, right,

from a career standpoint, from a personal standpoint,

and also what it allows you to do for the future for others,

I think is remarkable, but it is a retrospective look.

Now obviously, this may have not worked out.

If the AveXis program and the company hadn't succeeded,

people would have looked back at me and said,

"Well, we told you so," right?

But thankfully, that's not how it worked out.

It actually enabled me to open my world to obviously go

and work on multiple other gene therapy programs

as an investor, as a board member.

But frankly, financially, it also enabled me

to be very philanthropic.

Because one of the things I've been absolutely interested in

is helping other people in other parts of the world

where people are challenged economically.

So there's a lot of good you can do once you succeed

in your career, both from an emotional

and a career standpoint, but also financially.

So my collective conclusion here

is there's a lot you can do,

but you cannot do it by yourself.

If you have a family or a partner and children,

they all, hopefully, are with you to support you

and be there for you.

And then in terms of the calculated risk-taking,

tell us a little bit about that in terms of,

it's clearly paid off that you've had the ability

to walk into conversations with your board,

the rest of your executive team,

maybe say things that people didn't wanna hear,

but things that they had to hear

or that were really strong convictions for you.

Tell us about how you've gone about that

and maybe advice for others

in terms of when it's appropriate

or how to appropriately do it.

And now, you just mentioned you're a board member

for a number of organizations,

so I'm sure people are having those conversations with you.

How do you want those conversations to go

if they're going to?

Well, so, I mean, I have evolved over the years

where I've always decided, even as a young physician,

to follow my true north,

and that is really doing what you believe in.

So when I'm in situations from the time I remember

as a physician in my career, as it has evolved,

I've always made up my mind to do the right thing.

So whether it comes to making decisions

on organizational structure, clinical development plans,

patient safety, those are critical features to me,

and I will not allow anything to get in the way

of things that I believe.

And I have always decided that if I'm part of a team

that I feel I don't believe in their edict

and I don't believe in what they're doing,

I will have a open conversation.

And if it's not for me, I will walk away

'cause then I do not wanna be a part of that.

And that has always worked in my favor

because many people who may find that challenging

when somebody's very honest and open,

eventually appreciate that openness.

Because most of the time, it works in favor of the program

or whatever you're trying to achieve for patients.

'Cause remember, what all of us are doing in the world

of biotech and pharma or diagnostics

is we are trying to help patients, right?

So if we don't keep that in mind and we forget that,

eventually, not only do we hurt patients,

but we hurt ourselves and we hurt our company.

So this is something I kind of tell all my people around me,

always remember your true north, do the right thing.

It's much easier that way in the bigger scheme of things

and towards the end of life.

Right.

Definitely, it comes back to your early point

about the need for self-awareness not just in the skills

and the things that you're really good at,

but also in terms of what your true north is

and how you really think about your role

and things that you can and can't do in the industry.

So it's really important point here.

That's amazing.

And I think the courage is the part

that makes it really challenging to do that.

A lot of us know what the right thing it is

and we know exactly what we need to do.

But that extra step to have the courage to speak your mind

and telling to your leadership, to the board, to the CEO,

it takes a unique personality to be able to do that.

And thanks for sharing that, too.

That takes a lot to be able to do that.

To do some of what I just said,

you also have to take the risk that you may get fired.

Not every board nor every boss of yours

is going to want to address some

of these things you may put on the table.

And obviously, there has to be a certain way

to communicate these things

that are politically appropriate as well.

But then there are situations

where you may want to thump the table with your fist

because sometimes you need to get people's attention.

And I've done that more than a few times in my career, okay?

And I do that, especially when I feel people

are not hearing me and I feel that it is critical

for patients and patients' lives that I step up

and stick my neck out.

So I will always remind people

who want to be chief medical officers,

you have to do the right thing by your patients.

It doesn't matter what the share price is

or what you're trying to do for the board.

It's the patient first, okay?

As long as you remember that, you will be successful.

Tell us a little bit about talking

about the patients and your career.

And obviously, you have been incredibly successful

and have launched a lot of products, have also mentored

and hired many people in our industry.

And I believe recently you have established an award

for translational science.

Tell us a little bit about that.

What is that award? Why was this so important to you?

And what's your goal there?

Yeah, thanks for asking about that award, Ramin.

So this was an award my wife, Ann, and I established

at the American Society of Gene & Cell Therapy.

It's called the Jerry Mendell Clinical Translational Award.

So you know Dr. Jerry Mendell,

Nationwide Children's Hospital.

I am a huge fan of his, he doesn't know this, because he

and I used to have some very interesting conversations

when I was at AveXis as CMO.

But I took my hat off to him when he was the physician

who dosed the first child

in the spinal muscular atrophy type 1 trial

without prednisolone prep,

where he gave this child a trillion viral particles.

And that is what led to the history of AveXis

and the success of ZOLGENSMA.

And to me, Dr. Mendell has been at this field

for 40 years-plus.

So when I left AveXis,

and I was in a financial position to do so,

I felt I had to honor him in some way.

So this was one way for me to emphasize to the community

of gene and cell therapy

that you need brave translational physicians

who will take the animal data

and then be willing to work with patients,

whether they're children or adults, to make that difference

when it comes to the clinic.

And actually, ironically, the first recipient

of that award was Dr. Jerry Mendell himself

because the committee felt very strongly.

By the way, I had nothing to do

with the award being given to him, okay?

So I'm completely unbiased.

They felt this gentleman was incredible

in what he has done in his career.

And then the second winner was Dr. Kathy High,

who is also a pioneer. And I have a lot of respect for her.

And as y'all may know, she was president of R and D

and the chief medical officer of Spark Therapeutics.

So if you think about it, AveXis had ZOLGENSMA approved

for SMA type 1 in SMA,

and then you have Spark Therapeutics

that had the other gene therapy approved

for retinal dystrophy, right?

Another rare, difficult-to-treat disease.

So I felt incredibly honored that this simple award

that my wife and I put together for ASGCT

was able to actually recognize two of the pioneers

in gene and cell therapy.

That is incredible.

I think he's well aware of your affections now.

You can't really hide it anymore.

So Suku, many of the people that are gonna be listening

So Suku, many of the people that are gonna be listening

to this podcast probably are not at the stage

in their career that you are,

probably earlier in their career as CMOs or aspiring CMOs.

If you were to give them some advice

at this stage, what would it be?

What I would tell somebody

who wants to be a chief medical officer,

who just became a chief medical officer,

is number one, remember to be yourself.

Never forget who you are. Always be humble, okay?

That's the first thing.

Second is work on self-awareness.

Be very sure, eventually, of what you're good at,

what you like to do, what you're interested in,

and what your actual gaps are,

and how quickly those have to be filled.

Because many a time, I find young physicians,

or physicians who've just become,

or other experts in the field

who have become chief medical officers,

tend to get wrapped up in themselves

and suddenly get overwhelmed with what they have to achieve

and forget to build the network and the team around them.

If you look at my career, for example,

most of what I have done, I didn't do by myself.

I did it because of everybody around me.

And I sincerely mean it. Ramin, you are part of my team.

There were people at SSI.

There were many others,

Doug Feltner, Doug Sproule, Courtney Wells,

who were all part of my team.

I mean, if not for that incredible team around me at AveXis,

we would not have delivered

on everything we had to deliver on.

And obviously, I didn't refer to the C-suite,

Sean Nolan and others who were part

of the C-suite at AveXis,

and obviously, other companies that I'm involved with.

If not for this incredible team around me,

none of this could have been delivered as a CMO.

And this is what I would always remind a young,

up-and-coming CMO or somebody who wants

to be a chief medical officer,

is remember who you are, remember where your weaknesses are,

don't be shy to admit that you don't know,

and make sure you have the right network

and people around you.

Oh, and one more important thing.

Don't feel shy to ask for help.

I have never had a problem asking for help.

Actually, sometimes I think that's my strength.

And actually, sometimes even people think

maybe I'm a little crazy about that,

but I will put my hands up and say, "Guys, I need help

because I don't know what the hell I'm doing here."

And there's nothing wrong with that.

Absolutely. That's great advice, Suku.

We have come to at the end of our podcast.

And I know we can probably do another couple of hours

and questions.

We had so many different questions that we wanted to ask,

but we focus on these few for this first podcast

that we had with you.

So perhaps maybe in the future, you can join us.

I do wanna thank you for taking some time of your day

and be with us today.

And also, really appreciate sharing your knowledge,

your insight, your experience with us in such a candid way,

in such a authentic way and pragmatic way

that actually our listeners can take it to their day-to-day.

So Ramin and Kim, I wanna thank you for talking to me.

But can I leave both of you with one more thought?

Of course. - And this is for all of you,

including up-and-coming chief medical officers.

Remember that everybody around you matters,

which includes the person who opens your door,

the guy who takes you to the airport, right,

the guy who comes and does your work at the house.

Because all of these people can make a difference

in your lives.

And maybe someday, if you ever do another podcast,

I have stories of where a taxi cab driver changed my life,

where a doorman in New York City had significant influence

on what I did in biotech, et cetera.

And I'm telling you, people around you,

always be nice to them

because you never know when you need them, okay?

That's an incredible point.

So on that note, thank you again, folks, okay?

And have a good day, all right?

Thank you so much, Suku.

Great to see you, Suku.

Have a great day. Bye-bye.

Thanks for tuning in to

The Emerging Biotech Leader

an SSI Strategy Podcast.

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