Health Tech Nerds Radio

Otto Sipe, founder and CEO of Photon Health, joins following the company’s $16M Series A to discuss why prescribing infrastructure remains surprisingly antiquated, and why Photon believes the real opportunity is not transmitting prescriptions, but helping patients obtain them. Otto explains how Photon evolved from an e-prescribing network into a consumer-oriented prescribing marketplace focused on transparency, fulfillment, and patient navigation.

The conversation explores the broader prescribing ecosystem, including the limitations of legacy infrastructure, why “sending the XML document” is effectively a commodity, and how Photon is repositioning prescribing around the patient experience. Otto argues the real challenge begins after the prescription is written: pharmacy selection, insurance pricing, inventory availability, prior auth, and fulfillment.

Otto also discusses Photon’s go-to-market pivot toward health systems, where the company found stronger demand for pharmacy transparency and patient navigation. The discussion closes on why health systems increasingly operate around pharmacy economics, why pharmacy may become one of the most important patient engagement surfaces in healthcare, and how AI may further shift health systems toward medication-centered care models.

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Where we share our weekly news debriefs and discussions with industry experts. These are lo-fi recordings aimed at giving our readers more opportunities to engage with our analysis and a view into some of the conversations that shape it.

Martin: Photon Health just
closed a $16 million Series A.

It was led by Healthier Capital,
changing the way prescribing's happening.

Let's bring him up.

Otto.

Oh.

What's up, health tech nerds?

Oh.

Otto: How are we?

Martin: Looking great.

What a beautiful day.

Otto: It is a beautiful day here.

I'm, I'm, uh, coming to you live from
the garbage cans in front of Photon

World Headquarters here in Brooklyn.

Martin: Ooh.

Otto: What's going on?

Yeah.

Love it.

Martin: Fancy.

Otto: We recently got
some, uh, lawn chairs.

I don't know if you can see me.

I'm in a lawn chair.

Martin: Yeah.

Otto: Uh, it's a- That's the

Martin: exact lawn chair

... Otto: to take some meetings outside of,
uh, outside of the office this summer.

So-

Martin: Love it

... Otto: uh, here I am.

How are

Martin: you

Otto: guys?

Martin: So we're great.

We're great.

We were just talking about, about
primary care docs, but I wanna

switch gears and talk a little
bit about prescribing, uh- Yeah

an area that you and I both know and love.

Before we get into where Photon
is today, can you give us a little

bit of a, a, a landscape overview
of the e-prescribing- world.

And then also, uh, uh, when you
were starting Photon, what was

your going-in hypothesis on this?

Otto: Yeah.

Great.

Um, so e-prescribing is really just a, uh,
a transmission of a clinical order from

a clinician, uh, someone who's allowed
to write a prescription, uh, which is

an interestingly broad set of folks.

It's hard to define specifically,
but let's call them prescribers.

Um, you can click a button in the
EMR or some prescribing tool, and

then a, literally an XML document
moves through the internet and a, uh,

pharmacist is able to receive that
information, fill a prescription.

There's an enormous amount of state
built on top of prescriptions,

claims, adjudications, you know,
which is really sort of this

process before it becomes a claim.

Uh, prior auth, et cetera,
et cetera, et cetera.

But if you think about just, like, a
third of medical spend now is more or

less related to drugs in some capacity.

It's not all running through
e-prescribing, uh, 'cause you've got

lots of, lots of medical benefit drugs.

But the point is, prescribing
represents sort of the anchor

point of the clinical decision for
quite a lot of costs in healthcare.

So, you know, hearing you guys
talk about, uh, primary care

costs, et cetera, like, we all...

There's so much architecture built around
claims for medical care, but really

we s- sort of see prescribing as an
opportunity, uh, for major modernization

beyond just moving a clinical
prescription between point A to point B.

That feels like as complex as
sending as, an email, really.

Um, oddly, that was a problem that
a lot of the industry fought forward

from, you know, from 2000 to really
2014, I think we started to see

serious density in e-prescribing.

Good work Surescripts.

Um, but yeah, there's a ton of
opportunity, I think, to make that

process much more modern and much
more, uh, you know, sophisticated

in terms of the consumer experience,
which is what we're focused on.

But more, more importantly, it's a
trigger point for a lot of important

clinical spend, to, to tie into
what you were just talking about.

And then you asked, what is-
I- Why, why did I start Photon?

Martin: Yeah, yeah.

I was just like, w- what was
your going-in hypothesis?

Otto: Yeah.

Oh, it was, it was, it was actually a
little bit less of that versus, like,

you know, when you see behind the curtain
of something and you realize that it

is much less sophisticated than you
think it should be, or much less, uh,

you know, in my case it was much less.

Like, there was a missed opportunity,
uh, especially around engaging consumers.

The real hypothesis was that you
could build a modern ecosystem

around prescribing for prescribers,
patients, and pharmacy.

Um, so, you know, it really sort of
started with this, like, platform modern

data network thing and then, you know,
we realized further and further going

in that the consumer experience was the
sort of differentiation aha feature that

is a result of that type of network.

Um, but yeah, the hypothesis was really
just- Dang, this tech is actually not

that much harder to, uh, disrupt or
rebuild around the consumer or build

around a, a notion of transparency.

Um, but yeah, the hypothesis has sort
of been layered on as we've gone because

we've proven a couple of them to be true.

Uh, so it's interesting four and a half
years in here how, how it's changed.

Kevin: Otto, as I was reading the, your
blog post on the funding round, one of

the things that surprised me, not knowing
the e-prescribing market as well as

you guys do, and thinking that, like,
that hypothesis is, has been generally

the same, um, all along and kind of
you've been moving i- in that direction.

You describe the layoff in June 2025.

You describe kind of putting to, to,
to rest the old version of Photon

and, um, driving forward a new version
of Photon growth going forward.

Can you articulate, like, for someone
who doesn't understand the e-prescribing

landscape quite as well, what-
Yeah ... what was the old version?

What died?

What's the new version?

What changed from a business
model perspective underlying that?

Otto: So, I mean, a lot of this has to
do with the market we're selling in.

I think, like, the, the technical
product that I just described,

albeit not that clearly, uh,
really hasn't changed that much.

Um, but the, the observation
we, uh, focused on was that this

consumer enablement was the key
thing we enabled with this network.

So selling to anyone who needed a
network is not that interesting, and

you know, in this time last year really,
there was this huge spike in GLP-1

compounding where customers were using
our network to route from a prescriber

straight to a pharmacy, which is great.

We support that.

Um, the problem is it wasn't really
emphasizing our hero use case,

which was a scenario where a patient
could shop between pharmacies

with a prescription in hand.

So, um, the...

It, it was sort of, sort of a go-to-market
pivot really toward health systems, was

focused on, you know, who are the, where
are the organizations or the consumers

who benefit the most from transparency?

And you know, in retrospect, it's
obvious looking at, uh, health systems.

Health systems benefit enormously
from transparency for a lot of

reasons, primarily 'cause patients
have a lot of trouble navigating

even within the health system.

Uh, but more so, those
patients get the least support.

They have a few minutes with a doctor,
and then it's kind of good luck.

If you're routing prescriptions that
are all the same, the digital health

companies are actually pretty good
at support, uh, especially if most of

these medications are cash paid GLP-1s.

So we actually found that the more
complex and, like, diverse the set of

medications coming out of primary care
or cardio or whatever, um, the more the

opportunity for the marketplace where
the patient receives a text, they can

click a link, shop their prescription,
see, see their insurance pricing.

Um, that actually drives a much higher
value prop for the clinical team.

Martin: I think one of the things
that's interesting about where you're

operating now with the health systems
is, like, SureScripts would, I think,

like to do this, but their hands are...

I mean, I've worked there for six years.

From the outside, it seems like their
hands are tied by their ownership, now

minority ownership, and it's just hard
for them to actually do transparency.

You're spending a lot of time
talking to health systems.

It's an interesting
moment for health systems.

I'm curious what you're hearing as
you talk to them about, um, you know,

on the patient engagement front.

What's interesting them, what's
compelling to them, and why isn't

SureScripts able to, to pull it off?

Otto: Yeah.

I mean, uh, I, I'm not here to
say that they will or won't.

I, I don't think it, it matters what
SureScripts does or doesn't do for

us to succeed, which I think is a,
is an interesting facet of, of our

business because, you know, we, we've
long rhetorically positioned ourselves

as an alternative to SureScripts.

And the reason that is, is when a
health system or a large virtual clinic

goes live with Photon, they're sending
prescriptions through our network.

Um, but I, I kinda wanna think about
this a little differently because I think

there's a lot of companies that have
changed the way that people talk about

a space because, you know, I remember
in the, in, like, the early 2000s or the

mid 2010s really, when people built a
credit card integration on the internet,

they talked about, like, a merchant
account, and you'd go, like, get this

merchant account integration thing, and
they sat on top of Visa and all of it.

And, like, then Stripe came
along, and we stopped talking

about it as a merchant account.

Even though Stripe is technically, you
know, your, your merchant of record or

whatever the hell it is, uh, w- we got
to this place where, like, Stripe was

now a platform where it supported a ton
of different things, and it was oriented

around, like, the checkout experience.

So Stripe was able to sort of reposition
a market where they sort of did the same

underlying thing, like they charged your
credit card, but the product experience

around it was substantially different,
and that was what differentiated them.

We're trying to do the same thing
where, yes, we send e-prescriptions, but

e-prescriptions are a fricking commodity.

Like, if we could, we would make them
free or as cheap as possible to send.

You know, and we're really sort
of lowering our prices to transmit

as we grow, as, as, as economies
of scales make it cheaper for us.

But the l- larger phenomenon is, like,
the value we create is not in sending a

prescription, it's in actually helping the
patient get their medication physically.

And I think that if you think about this
in terms of the value to healthcare,

g- going and solving a much bigger
problem than moving an XML document

on the internet is really our calling.

Um, which I think is sort of the key
thing that's been true across our whole

journey at Photon, is we don't wanna just-
Solve simply the technical integration

problem, but actually the human
problem of did you get your medication?

Uh, which if you think about
that in terms of the value to

a health system is enormous.

Of the value to a payer is enormous.

The value to a pharma
company i- is enormous.

Like, the, uh, market itself is
inefficient between those three parties,

and if you can increase the likelihood
of those, that event occurring, that

transaction, that payment, that clinical
authorization occurring more rapidly, if

you will, uh, the value is pretty huge.

So, you know, that is
kind of an open problem.

It's existed well before Photon,
and I don't know what has kept other

organizations from solving it before
us, uh, other than the fact that

the immediate ROI on solving that
problem is a little complex to unlock.

Kevin: Yeah.

It's

Otto: like a, it's a hard problem.

Kevin: So in many ways it, it, like
it, it feels like you're expanding to

it, like, you know, having sat inside
health system and payers before, like,

there's always this conversation of last
mile engagement, how you actually...

It's one thing to tell a patient to
go take their, you know, Lasix dose

for heart failure, what have you.

It's another thing to actually make
sure that that happens, get the

data on it, understand what's going
on, track outcomes against that.

Am I hearing you right in saying that you,
like, y- you're stepping into that space

over time, and that's where you think
the interesting space is to play of that,

like, last mile engagement nut to crack?

Like, how- Yeah ... how are
you thinking about that?

Yeah.

Otto: Yeah, I mean, I, w- by, by means
of building a product that, uh, you know,

sends a prescription to a patient via
text- Yeah ... the opportunity to take

on a lot more responsibility for- For

Kevin: sure

... Otto: the state changes
related to a prescription.

So the obvious ones being,
is this pharmacy open?

Is this pharmacy nearby?

Uh, does this pharmacy take my insurance?

Is this pharmacy in stock?

Like, just basic fulfillment level stuff.

Kevin: Is the pharmacist on break-
Does this pharmacy- ... and I have

to wait for, like, 35 minutes?

I mean- Because I didn't know
they're on break before I get there.

Yeah, it's cra- sorry.

Otto: Lunch hours are real.

Lunch hours are real.

Um, and then more so we, we realize that
there's like nine other really complicated

transactions that sit behind this.

Prior auth is one we're
starting to think a lot about.

Uh, you know, not to mention the
actual adjudication or cost associated

with that medication varies depending
on a lot of different factors.

So, you know, there's like 12
different ways to pay for a

medication, it feels like these days.

Um, not, not, not including
the different pharmacy options.

So, you know, the, the big goal for
us is to sort of streamline all the

different decisions that g- go from
clinical order all the way through to

physically receiving your prescription,
where e-prescribing is only one

tiny component of that, and arguably
not the most important component.

It's a good gateway to go solve
these other problems, though.

And again, this is, you know, a common
startup company strategy, which is like

go take a sort of antiquated part of
the market, go solve a problem there,

and then go expand into the downstream.

Uh, yeah, I don't think we're
doing anything that crazy.

Our roadmap in some ways is
honestly kind of obvious.

Martin: Last question for you, um,
and then I'll let Kevin hop in.

But how much of the, the problem is
for, for, you know, sort of patient

engagement is price sensitivity
versus some other stuff that I guess

that people would, would not expect?

Otto: So price sensitivity or like
i- in some ways difference between

pharmacies isn't yet the problem,
because most patients don't even know

the price of the first pharmacy, at
least until you get to the counter.

So we think of shopping a little bit
less in the current state around,

you know, this pharmacy versus this
pharmacy, though that is important.

Some pharmacies are in
your network, some are not.

Uh, s- you know, some pharmacies are
just more expensive than others, period.

Um, you have this problem where
just knowing the price at all is

actually the bigger issue in pharmacy.

So, you know, we're focused primarily
on this notion of like a, a cost

basis, because when you go into
Walmart and purchase milk, you

have a cost basis for milk, right?

You, you know what a fair price is
relatively speaking, and you'd know

when to say, "Wow, that's a whole lot
for, you know, half a gallon of milk."

Um, so much so that you can even
disambiguate between different

offers of milk in the same store.

Uh, you know, this is the premium
milk, uh, you know, at, at $4.50.

So, uh, in some ways I think getting to
that level of granularity where consumers

feel like they have a cost basis in
prescribing is really what we think about.

Um, and it's amazing how many people
miss that w- when their own experience

in pharmacy yields, like you have no
idea what something costs, and the amount

that you pay for it actually has very
little to do with how much you're willing

to pay to access the treatment on the
other end of the, of the prescription.

I think that's actually a huge problem
in the way that the market works.

But we're not solving that one yet.

Kevin: Otto, if I'm a primary care doc
or other doc in a system who's listening

to you talk and who's like, "Yeah, I
want Photon for, you know, my patients

to, to get access to," where are you
finding entry points in health systems?

Who should they be sending you
to talk to inside their system?

Like, what's the, what's the sales
process of getting a health system

to say, "Yep, we're on board"?

Otto: So without a doubt, the f- the
health system pharmacy Uh, is the best

place for us to, to work because I think
they see the underlying inefficiency

because in a lot of ways the pharmacy
at a health system sort of holding

the bag operationally for a lot of,
a lot of upstream complexity like

patients, A, not even showing up, not
knowing what their medications costs.

Um, you know, pharmacies are operational
powerhouses and health system

pharmacies have a lot of opportunity to
basically take some of the operational

burden and put it either into the
patient experience or automate it,

which is a lot of what we're doing.

Um, so that's just where
pharmacies are most focused.

It's also where the ROI is,
is creative directly in terms

of pharmacy transparency.

Um, health systems from a clinical
perspective also usually always have

like one, you know, CMIO type who's a
huge champion for clinical experience.

Those folks generally love what we're
doing, but they're not our buyer,

primarily because they don't think about,
uh, the prescribing already exists in

all their workflows, so we're not really
doing anything net new for the clinician.

We're really doing something
net new for the patient.

And I think this is actually an
interesting phenomenon that Blake, uh,

wrote about in the hospitalogy coverage
of Photon, that there isn't really a

structure within health systems from an
executive perspective where someone owns

the patient experience end to end from
an ROI or from a financial perspective.

And, you know, Blake, I think,
has been kind of pushing on this

directive for, for a while, and, and
he's not the only one doing this.

Like, health systems need to think
about patients from an LTV perspective.

And Blake actually made an argument
more clearly than I think I've

made it to a health system, which
is that a patient interacts with

primary care maybe once a year.

W- I think the stats officially are 1.8

across the whole population.

They interact with pharmacy 10
times more often, uh, especially

if they're on multiple medications.

So you get to this point where, okay, the
obvious consumer touch point for a brand

to focus on is the pharmacy touch point.

You could even think of a world where
the health systems operate around the

cadence of pharmacy fulfillment more than
they do around medical claims or labs.

Uh, w- which could start to make
sense, especially if you think about

what actually makes people better.

You know, a doctor can spend as
much time as they want with you,

but it's not gonna make you better.

They need to either cut you open
or put medication inside of you.

Maybe they can give you a medical device.

So there's one that is the most common
treatment pathway, so it does actually

make sense at scale, especially as AI
becomes increasingly able to provide

clinical care directly, that health
systems should operate around pharmacy.

And if you start to look at the books
a little bit closer, health systems

already operate around pharmacy from
a margins perspective, so it's not

too much of a stretch to think about
health systems really as Much more

complex pharmacies in the future.

Um, and, and I think that, you know,
I'm not the first to say that out

loud, but that's, that's why we
spike on, you know, CPOs and VPs

of ambulatory as our core buyers.

Martin: Well, if I am a CPO or a, a
VP of ambulatory and I wanna get in

touch and bring Photon in, what's
the best way for me to reach out?

Otto: Honestly, just, uh, you
know, send, send us a note.

I think, you know, uh, no one likes
going through a sales channel, right?

You know, like signing up on a
website or emailing sales@photon.

But I think, you know, just send
me a note, otto@photon.health.

Um, and, and, you know, let me know
where some of your pain points are.

Like, whether it be, uh, you know, helping
patients understand what, you know, where,

what pharmacies are available to them.

I think one common pain point we
hear among clinical leaders at

health systems are that pharma
rapidly around their locations.

So building infrastructure inside
of the health system experience that

helps patients navigate that, uh, is,
is critical for them meeting outcome

as, outcomes measures or, you know,
let alone just, like, providing care.

Like, these, these
systems care about that.

So yeah, drop us a line.

Um, we've actually this week oddly been
having a lot of health systems sign

up on our website, which is kind of an
amazing thing, um, that, like, health

systems are signing up on our website.

So, uh, yeah, feel free to sign up on
our website and we'll shoot you a note.

But generally speaking, we're trying
to be as responsive as possible,

uh, to folks who, who reach out.

Martin: Otto, appreciate the time.

Best of luck with everything.

Enjoy that beautiful
Brooklyn, Brooklyn afternoon.

Otto: Appreciate you guys.

Thanks for your time.

Thanks, Otto.

Martin: See you.

Otto: Bye.